Results 141 to 150 of about 243,891 (236)

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

EV‐SPEC: Decoding the Spatial Proteomic Signature of the Extracellular Vesicle Corona

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
This study introduces ‘EV‑SPEC’, a spatial proteomics method using TurboID fused to the transmembrane protein CD63 to map the protein corona of extracellular vesicles (EVs) without physical isolation. We show that EV‐SPEC identifies the protein‐protein interaction footprint of serum proteins, similar to those typically found on synthetic nanoparticles,
Camille Menaceur Vandenbroucke, Carsten Scavenius, Yuya Hayashi   +2 more
wiley   +1 more source

Role of annexin A2 and osteopontin for early diagnosis of hepatocellular carcinoma in hepatitis C virus patients

Egyptian Liver Journal, 2019
Background Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally. Early stages of hepatocellular carcinoma (0&A) can be treated with curative procedures.
Abd El-Fattah F. Hanno, Fatma M. Abd El-Aziz, Akram A. Deghady, Ehab H. El-Kholy, Aborawy I. Aborawy   +4 more
doaj   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Plasmid Sequences for Gene silencing of Annexin a2 receptor.

, 2016
Plasmid Sequences for Gene silencing of Annexin a2 receptor.
Xin Zheng (104081), Hongdie Jiang (822631), Shunxiang Gao (2558725), Bo Hu (126105), Yan Zhu (112437), Mingjuan Sun (764681), Jun Yi (839345), Dejing Liu (2558731), Kaihui Wang (2558728), Binghua Jiao (158407), Yin Jia (500693), Lianghua Wang (158395)   +11 more
core   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Natural Monoterpene Stylosin Induced Anticancer Effects on Human Colon Carcinoma Cells

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
Extraction of STL from Ferula ovina by TLC and structural confirmation by 1H NMR. Favorable pharmacokinetics. Reduced CRC cell viability in a time‐ and dose‐dependent manner. Induced apoptosis. Interacted with the active site of HGFR. ABSTRACT Colorectal carcinoma (CRC) ranks among the top five most common malignancies globally, characterized by a high
Sara Seyedshazileh, Amirabbas Abdollahi, Mehrdad Iranshahi, Fatemeh B. Rassouli   +3 more
wiley   +1 more source

Aging Impairs Macrophage Phagocytosis Through Mitochondrial ROS‐Induced Collagen Production

Aging Cell, Volume 25, Issue 6, June 2026.
Aging compromises macrophage phagocytosis via the mitochondrial ROS‐driven overproduction of intracellular collagen. This excess collagen physically binds F‐actin, paralyzing cytoskeletal turnover; however, mtROS scavenging successfully rescues actin dynamics and restores phagocytic capacity.
Yuming Wang, Xin Xu, Nuanqin Shen, Ping Han, Liuyi Wu, Yi Jin, Yiming Sun, Lanlan Xiao, Jinyou Li, Lan Wang, Yunmei Yang, Qin Zhang, Weiqian Chen, Chaohui Yu, Bowen Wu   +14 more
wiley   +1 more source

Structure – Function Studies of Annexin A2 & A5 [PDF]

, 2014
University of Minnesota Duluth 2014 UROP paperSwenson College of Science and Engineering, University of Minnesota DuluthSchramel, Stephanie. (2014). Structure – Function Studies of Annexin A2 & A5. Retrieved from the University Digital Conservancy, https:
Schramel, Stephanie
core  

Overexpression of Annexin A2 Is Associated with Abnormal Ubiquitination in Breast Cancer

, 2012
Abnormal expression of annexin A2 contributes to metastasis and infiltration of cancer cells. To elucidate the cause of abnormal expression of annexin A2, Western blotting, immunoproteomics and immunohistochemical staining were performed to analyze ...
Deng, Shishan, Jing, Baoqian, Xing, Tianyong, Yang, Zhengwei, Hou, Lingmi   +4 more
core   +1 more source