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Annexin A2 Heterotetramer: Structure and Function [PDF]

International Journal of Molecular Sciences, 2013
Annexin A2 is a pleiotropic calcium- and anionic phospholipid-binding protein that exists as a monomer and as a heterotetrameric complex with the plasminogen receptor protein, S100A10. Annexin A2 has been proposed to play a key role in many processes including exocytosis, endocytosis, membrane organization, ion channel conductance, and also to link F ...
David M Waisman
exaly   +4 more sources

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S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors

Frontiers in Bioscience, 2005
The defining characteristic of a tumor cell is its ability to escape the constraints imposed by neighboring cells, invade the surrounding tissue and metastasize to distant sites. This invasive property of tumor cells is dependent on activation of proteinases at the cell surface.
Mijung, Kwon, Travis J, MacLeod, Yi, Zhang, David Morton, Waisman   +3 more
openaire   +2 more sources

The annexin A2 system and angiogenesis

Biological Chemistry, 2016
AbstractThe formation of new blood vessels from pre-existing vasculature, the process known as angiogenesis, is highly regulated by pro- and anti-angiogenic signaling molecules including growth factors and proteases. As an endothelial cell-surface co-receptor for plasminogen and tissue plasminogen activator, the annexin A2 (ANXA2) complex accelerates ...
Wei, Liu, Katherine A, Hajjar
openaire   +2 more sources

The association of annexin A2 and cancers

Clinical and Translational Oncology, 2012
Annexins are a group of calcium- and phospholipid-dependent proteins. As a member of the annexin, annexin A2 (Anxa2) is widely distributed in nucleus, cytoplasm and extracellular surface and mainly expressed in human endothelial cells, mononuclear cells, macrophages, marrow cells and some tumor cells.
Xiaohui, Zhang, Shuqing, Liu, Chunmei, Guo, Junwei, Zong, Ming-Zhong, Sun   +4 more
openaire   +2 more sources

Annexin A2: better left alone

Blood, 2005
Zhang and McCrae demonstrate that APLA/b2GPI-mediated endothelial cell activation occurs via dimerization of annexin A2 molecules on the cell surface.
Alisa S, Wolberg, Robert A S, Roubey
openaire   +2 more sources

Annexin A2, autoimmunity, anxiety and depression

Journal of Autoimmunity, 2016
Antiphospholipid syndrome (APS) is associated with neurological manifestations and one of the novel autoantigens associated with this disease is Annexin A2 (ANXA2). In this work we have examined the effect of high levels of autoantibodies to ANXA2 on the brain in a mouse model.Recombinant ANXA2 emulsified in adjuvant was used to immunize mice while ...
R, Weiss, A, Bitton, M, Ben Shimon, S, Elhaik Goldman, L, Nahary, I, Cooper, I, Benhar, C G, Pick, J, Chapman   +8 more
openaire   +2 more sources

Vascular expression of annexin A2 in lupus nephritis

Journal of Clinical Pathology, 2015
Aims To evaluate vascular expression of annexin A2 (ANXA2) and its subunit S100A10 in lupus nephritis (LN). Methods The present histological study included 14 patients with LN and 11 controls (patients with non-lupus kidney diseases ...
Salle, V., Cordonnier, C., Schmidt, J., Maziere, C., Smail, A., Attencourt, C., Mabille, M. P., Maziere, J. C., Makdassi, R., Choukroun, Gabriel, Diouf, M., Duhaut, Pierre, Ducroix, J. P.   +12 more
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Annexin A2 autoantibodies in thrombosis and autoimmune diseases

Thrombosis Research, 2015
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial, venous or small-vessel thrombotic events, and recurrent miscarriages or fetal loss. APS diagnosis is based on the repeated detection of anti-phospholipid (PL) antibodies (Ab), typically associated with anti-β2 glycoprotein I (β2GPI)-Ab.
Felipe Cañas, Laurent Simonin, Francis Couturaud, Yves Renaudineau   +3 more
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The role of the annexin A2 heterotetramer in vascular fibrinolysis

Blood, 2011
AbstractThe vascular endothelial cells line the inner surface of blood vessels and function to maintain blood fluidity by producing the protease plasmin that removes blood clots from the vasculature, a process called fibrinolysis. Plasminogen receptors play a central role in the regulation of plasmin activity.
Patricia A, Madureira, Alexi P, Surette, Kyle D, Phipps, Michael A S, Taboski, Victoria A, Miller, David M, Waisman   +5 more
openaire   +2 more sources