Results 41 to 50 of about 2,193,796 (297)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Pre-exposure prophylaxis persistence at two sites in an integrated primary health care programme in South Africa

Frontiers in Public Health
IntroductionHIV continues to be a public health concern and pre-exposure prophylaxis (PrEP) has become an important HIV prevention strategy. We examined PrEP persistence over time in two health facilities in Gauteng, South Africa.MethodsWe conducted a ...
Nosipho Shangase, Anele Jiyane, Fezile Buthelezi, Cara O’Connor, Ben Brown, Kate Rees, Kate Rees   +6 more
doaj   +1 more source

Sexual transactions between long distance truck drivers and female sex workers in South Africa

Global Health Action, 2017
Background: Female sex workers (FSWs) and long distance truck drivers (LDTDs) are considered key populations at high risk for HIV transmission due to high prevalence.
Nosipho Faith Makhakhe, Tim Lane, James McIntyre, Helen Struthers   +3 more
doaj   +1 more source

Towards 'men who have sex with menappropriate' health services in South Africa

Southern African Journal of HIV Medicine, 2013
Health programming for men who have sex with men (MSM) in South Africa has been ignored or absent until fairly recently, despite this population being at high risk for HIV acquisition and transmission.
Kevin Brian Rebe, Glenn De Swardt, Helen Elizabeth Struthers, James Alisdair McIntyre   +3 more
doaj   +1 more source

ANOVA-table and Bayes Factors of Experiment 2.

, 2016
ANOVA-table and Bayes Factors of Experiment 2.
Peter Gerjets (755310), Martin H. Fischer (461957), Susana Ruiz Fernandez (3331362), Nils-Alexander Bury (3331356), Otmar L. Bock (3331359), Martin Lachmair (383071)   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Challenges to delivering quality care in a prevention of mother-to-child transmission of HIV programme in Soweto, South Africa

Southern African Journal of HIV Medicine, 2013
Objectives: There has been little focus on quality of care provided in prevention of mother-to-child transmission of HIV (PMTCT) services in South Africa.
Coceka Nandipha Mnyani, James McIntyre
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Barriers and facilitators to HIV index contact testing in facility and community settings

Southern African Journal of HIV Medicine
Background: The WHO emphasises contact investigation of people with HIV for case finding. However, satisfactory implementation of index contact testing remains challenging in Johannesburg.
Nyeleti Pretty Chauke, Cathrine Chinyandura, Fezile Buthelezi, Anele Jiyani, Kate Rees   +4 more
doaj   +1 more source

Shiny application to conduct heteroscedasticity consistent ANOVA (in Russian)

, 2017
<p>Shiny application to conduct heteroscedasticity consistent ANOVA (in Russian).</p> <p>Methods available:</p> <ul> <li>ANOVA based on a heteroscedasity-consistent standard errors (White-Huber covariance matrice ...
Vladimir Mikryukov
core   +1 more source