Results 61 to 70 of about 2,239,865 (298)
Barriers and facilitators to HIV index contact testing in facility and community settings
Southern African Journal of HIV MedicineBackground: The WHO emphasises contact investigation of people with HIV for case finding. However, satisfactory implementation of index contact testing remains challenging in Johannesburg.
Nyeleti Pretty Chauke +4 more
doaj +1 more source
Southern African Journal of HIV Medicine, 2013 Data use and data quality continue to be a challenge for government sector health facilities and districts across South Africa. Led by the National Department of Health, key stakeholders, such as the Anova Health Institute and district health management ...
J Murphy +3 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Differentiated antiretroviral distribution: Implementation in five South African districts
African Journal of Primary Health Care & Family MedicineBackground: The National Department of Health introduced Differentiated Service Delivery (DSD) models to improve retention in care and decongest healthcare facilities.
Justin Engelbrecht +3 more
doaj +1 more source
Cladding welding of CA6M with pulsed FCAW and results analysis through the L9 TAGUCHI and ANOVA [PDF]
, 2018 The cladding welding analysis with pulsed flux cored arc welding (FCAW) process, were carried over a AISI 1020 base metal (thickness 12,7 mm, width 63,5 and length 185mm) with an CA6NM steel wire with diameter of 1.2mm.
Moreno, Joao +6 more
core +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Programmatic outcomes of adolescents in differentiated service delivery models in South Africa
Southern African Journal of Infectious DiseasesBackground: Adolescents living with HIV face barriers that impede adherence and retention. Differentiated service delivery (DSD) models aim to improve retention and viral suppression (VS), but there is limited programmatic evidence from South Africa on ...
Phumzile M. Shaku +5 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Southern African Journal of HIV Medicine, 2019 Background: Despite widespread availability of antiretroviral therapy (ART) in South Africa, there remains a considerable burden of human immunodeficiency virus (HIV)-related morbidity and mortality.
Rivka R. Lilian +5 more
doaj +1 more source