Results 71 to 80 of about 1,981,243 (338)
Southern African Journal of HIV Medicine, 2014 In this review of routinely collected data from five community health centres in the Johannesburg Health District, we assess timing of antenatal care and antiretroviral therapy (ART) initiation in HIV-infected pregnant women before and after the ...
Coceka Nandipha Mnyani +5 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Public Men’s Clinic: Men’s experiences of healthcare professionals and environment
African Journal of Primary Health Care & Family MedicineBackground: Men often face social barriers linked to norms and systemic issues when engaging with public healthcare services. South Africa’s first Public Men’s Clinic (PMC) was established in 2020, and now, 20 more clinics operate across the country ...
Lawrence L. Mamabolo +2 more
doaj +1 more source
, 2020 Surface finishing and polishing are important quality assurance processes in many manufacturing industries. A polished surface (low surface roughness) is linked with many useful properties other than providing an appealing gloss to the product, such as ...
Imran Mohsin +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Multi-institutional Registry for Prostate Cancer Radiosurgery: An Observational Clinical Trial
Frontiers in Oncology, 2015 Title: Multi-institutional Registry for Prostate Cancer Radiosurgery: An Observational Clinical TrialAuthors: Debra Freeman, MD*; Gregg Dickerson, MD; Mark Perman, MDObjective: To report on the design, methodology and early outcome results of a multi ...
Debra eFreeman +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Providing HIV care to men who have sex with men in South African state sector clinics
Southern African Journal of HIV Medicine, 2014 -
Kevin Brian Rebe, James McIntyre
doaj +1 more source