Results 51 to 60 of about 34,133 (309)

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

Biomimetic Organic Nanozyme as Tumor Vaccines for Targeted Suppression of Ammonia‐Induced T Lymphocyte Death to Augment Breast Cancer Immunotherapy

Advanced Science, EarlyView.
The organic nanozyme IR‐IHpd, which has NIR‐PDT and POD‐like activity, is designed for continuous ROS generation. It is co‐encapsulated with CB‐839 and coated with DC membranes to simultaneously target tumors and T cells. Under NIR irradiation, immunogenic cell death is activated. Concurrently, CB‐839 suppresses ammonia‐induced T lymphocyte death (AITD)
Meng Suo, Deyi Yang, Mingpu Yang, Jue Wang, Dingfeng Zhang, Daoming Zhu, Qingyong Xu, Yanni Song   +7 more
wiley   +1 more source

Potential or contraindicated drug–drug interactions with antiretroviral therapy in real-world settings in Taiwan

Journal of the Formosan Medical Association, 2022
Background/Purpose: Given the complex metabolic pathway of antiretroviral therapy (ART), polypharmacy may increase the risk of drug–drug interactions (DDIs). Therefore, we investigated the frequency of DDIs during ART exposure to improve medical care for
Chi-Chuan Wang, Hsing-Jung Li, Chi-Hao Shao, Wang-Huei Sheng   +3 more
doaj   +1 more source

Pearl‐Like Bioinspired Coating Enables Regulation of Mg Degradation for Osteoporotic Bone Repair

Advanced Science, EarlyView.
In this study, inspired by pearl architecture, we developed a layered Ca–P “brick” and Fn‐mimetic peptide “mortar” coating on Mg alloys. The Ca–P layer moderates corrosion and offers mineral cues, while the peptide enhances adhesion and regulates immune‐vascular responses.
Siming Zhang, Tao Zhang, Yuan Chen, Nikolaos Kourkoumelis, Mo Chen, Jiale Dong, Zhenyu Li, Yanling Zhou, Ning Li, Chen Zhu, Xifu Shang, Jiaxiang Bai, Xianzuo Zhang   +12 more
wiley   +1 more source

Updates in Gastroesophageal Reflux Disease Management: From Proton Pump Inhibitors to Dietary and Lifestyle Modifications

Gastrointestinal Disorders
Gastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that greatly influences patients’ quality of life and represents a growing public health concern.
Jakov Ivan Bucan, Tamara Braut, Antea Krsek, Vlatka Sotosek, Lara Baticic   +4 more
doaj   +1 more source

New Natural Marine Antacid Drug from Cuttlebone [PDF]

Pharmaceutical Sciences, 2018
Background: Antacids are the most commonly used medications for fast symptomatic relief of gastric disorders. Because of adverse effects, low efficiency and the high cost of some chemical antacids, identifying a natural medicine with high efficiency and ...
Azar Mostoufi, Neda Bavarsad, Sahar Aryanfar, Abbas Akhgari   +3 more
doaj   +1 more source

Influence of the Degree of Substitution of Carboxymethyl Cellulose Binders on the Properties and Performance of Aqueously Processed LiNi0.6Mn0.2Co0.2O2‐Based Positive Electrodes—A Comparative Study

Advanced Energy and Sustainability Research, EarlyView.
Aqueous processing of positive electrodes is a crucial step toward sustainable production of lithium ion batteries. Therein, the individual properties of the binding agent can largely influence processing, the physical electrode properties, and thus, the electrochemical performance and cycle life.
Johanna Kauling, Chirag Vankani, Martin Winter, Markus Börner   +3 more
wiley   +1 more source

Mechanistic Insights Into Cellulose Dissolution in Solvents for Advanced Industrial Applications: A Systematic and Bibliometric Review

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Cellulose dissolution is important for various industries, including textiles, bioplastics, foods and pharmaceuticals, yet achieving efficient dissolution remains challenging. Deep eutectic solvents (DES) have emerged as promising alternatives to traditional solvents due to their low toxicity, biodegradability and sustainability.
Chigozie Charity Okwuwa, Fatmawati Adam, Michael E. Ries, Nor Hanuni Ramli, Samuel Olugbenga Olunusi   +4 more
wiley   +1 more source

Pharmacokinetic profiles of sertraline in pregnancy as a predictor of postpartum depressive symptoms

British Journal of Clinical Pharmacology, EarlyView.
Aim To characterize pharmacokinetic changes of sertraline and its metabolite during pregnancy and postpartum, and their relationship to maternal postpartum depressive symptoms. Methods This was a prospective observational, longitudinal study of pregnant women with a major depressive disorder treated with sertraline (N = 185 women, 205 pregnancies ...
Sílvia M. Illamola, Zachary N. Stowe, Marc L. Kalin, Michael D. Evans, Catherine M. Sherwin, Maged M. Costantine, D. Jeffrey Newport, James C. Ritchie, Angela K. Birnbaum   +8 more
wiley   +1 more source

Obesity is positively associated with dehydroepiandrosterone sulfate concentrations at 7 y in Chilean children of normal birth weight. [PDF]

, 2013
BACKGROUND: In low-birth-weight girls, obesity increases the risk of premature adrenarche and metabolic complications. However, the consistency of this association in normal-birth-weight children and its potential mediators remain unknown.
Baquedano, Camila Corvalán, Charkaluk, Cohen, Cook, Corvalán, de Onis, D’Adamo, Fernandez, Genazzani, Gonzales, Guercio, Guercio, Havelock, Ibáñez, Ibáñez, Ibáñez, Idkowiak, Iñiguez, Jean, Kain, Kelnar, Khan, l’Allemand, Mentzel, Mericq, Ong, Palmert, Parker, Popkin, Rainey, Remer, Remer, Ricardo Uauy, Rittmaster, Rosenfield, Silfen, Slaughter, Smith, Sopher, Tanner, Topor, Utriainen, Verónica Mericq, Williams, Yu   +45 more
core   +1 more source