Results 131 to 140 of about 506,624 (381)
Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes
bioRxiv, 2017 Over 95% of human multi-exon genes undergo alternative splicing, a process important in normal development and often dysregulated in disease. We sought to analyze the global splicing regulatory network of CELF2 in human T cells, a well-studied splicing ...
Matthew R. Gazzara +6 more
semanticscholar +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Metabolic Diversity of Rhizospheric Pseudomonas species of Bt Cotton Plant
Journal of Pure and Applied Microbiology, 2018 A total 20 Pseudomonas species were isolated from BT cotton rhizosphere of 3 different regions of Nanded city. All these isolates were evaluated for plant growth promoting functional traits like plant hormones production, Phosphate solubilisation ...
Abhijeet S. Joshi, M.P. Chitanand
doaj +1 more source
Stage Left: A Review of Contingency, Hegemony, Universality: Contemporary Dialogues on the Left [PDF]
, 2020 Reviews the three way conversation among Ernesto Laclau, Slavoj Zizek, and Judith Butler on leftist political theories of hegemony and universality and social change.
Maccannell, Juliet
core
Supplementary Figure 2 from Antagonism of Inhibitor of Apoptosis Proteins Increases Bone Metastasis via Unexpected Osteoclast Activation [PDF]
, 2023 Chang Yang +11 more
openalex +1 more source
Concentration-Dependent Antagonism and Culture Conversion in Pulmonary Tuberculosis
Clinical Infectious Diseases, 2017 Summary The relationship between drug concentrations, minimum inhibitory concentrations, and sputum culture conversion in tuberculosis is unclear. We identified concentration-dependent antagonism between isoniazid and rifampicin that was associated with ...
N. Rockwood +8 more
semanticscholar +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
NTIFUNGAL POTENTIAL OF EXO-METABOLITES PRODUCED BY PENICILLIUM CAPSULATUM AGAINST PHYTOPATHOGENIC FUNGI [PDF]
Acta Scientifica MalaysiaFungi are well-known producers of secondary metabolites, commonly referred to as exo-metabolites, which play crucial roles in ecological interactions, including plant protection.
Niharika Mohanty +2 more
doaj +1 more source