Results 1 to 10 of about 1,012,981 (340)

Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies

Frontiers in Endocrinology, 2023
Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. PRL is reported to play a role in pregnancy, mammary gland development, immune modulation, reproduction, and differentiation of islet cells. PRL binds to its receptor
David Standing, Prasad Dandawate, Shrikant Anant   +2 more
doaj   +1 more source

Targeting TNFR2 in Cancer: All Roads Lead to Rome

Frontiers in Immunology, 2022
TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs).
Jingchao Bai, Jingchao Bai, Jingchao Bai, Bowen Ding, Bowen Ding, Bowen Ding, Hui Li, Hui Li, Hui Li   +8 more
doaj   +1 more source

GPR35 antagonist CID-2745687 attenuates anchorage-independent cell growth by inhibiting YAP/TAZ activity in colorectal cancer cells

Frontiers in Pharmacology, 2023
Background and purpose: GPR35, a member of the orphan G-protein-coupled receptor, was recently implicated in colorectal cancer (CRC). However, whether targeting GPR35 by antagonists can inhibit its pro-cancer role has yet to be answered.Experimental ...
Wuxiyar Otkur, Xiaolong Liu, Huan Chen, Siyi Li, Ting Ling, Hanchen Lin, Renyu Yang, Tian Xia, Huan Qi, Hai-Long Piao   +9 more
doaj   +1 more source

Insight into a Successful Development of Biocontrol Agents: Production, Formulation, Packaging, and Shelf Life as Key Aspects

Horticulturae, 2022
Biocontrol agents (BCAs) have been proposed and studied over recent decades as a suitable alternative to diminish or substitute synthetic fungicides used to control pre- and postharvest diseases.
Neus Teixidó, Josep Usall, Rosario Torres   +2 more
doaj   +1 more source

Untargeted Metabolomics Reveals the Potential Antidepressant Activity of a Novel Adenosine Receptor Antagonist

Molecules, 2022
Depression is the most common mental illness, affecting approximately 4.4% of the global population. Despite many available treatments, some patients exhibit treatment-resistant depression.
Arnold Petrus Smith, Jeremie Zander Lindeque, Mietha Magdalena van der Walt   +2 more
doaj   +1 more source

Adverse cardiovascular effect following gonadotropin-releasing hormone antagonist versus GnRH agonist for prostate cancer treatment: A systematic review and meta-analysis

Frontiers in Endocrinology, 2023
BackgroundAndrogen deprivation therapy is the mainstay of medical treatment for prostate cancer (Pca); however, it is associated with an increased risk of adverse cardiovascular (CV) events and death.
Li Gu, Xurui Li, Wentao Liu
doaj   +1 more source

Interaction of GABA and Excitatory Amino Acids in the Basolateral Amygdala: Role in Cardiovascular Regulation [PDF]

, 1997
Activation of the amygdala in rats produces cardiovascular changes that include increases in heart rate and arterial pressure as well as behavioral changes characteristic of emotional arousal.
Cook, Jennifer C., Gregg, Adam E., Sanders, Brian J., Soltis, Robert P.   +3 more
core   +2 more sources

Opposite Roles of Wnt7a and Sfrp1 in Modulating Proper Development of Neural Progenitors in the Mouse Cerebral Cortex

Frontiers in Molecular Neuroscience, 2018
The Wingless (Wnt)-mediated signals are involved in many important aspects of development of the mammalian cerebral cortex. How Wnts interact with their modulators in cortical development is still unclear.
Nan Miao, Shan Bian, Trevor Lee, Taufif Mubarak, Shiying Huang, Zhihong Wen, Ghulam Hussain, Tao Sun, Tao Sun   +8 more
doaj   +1 more source

Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]

, 1991
We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
core   +2 more sources

Structural basis for the antiviral activity of BST-2/tetherin and its viral antagonism

Frontiers in Microbiology, 2011
The interferon-inducible host restriction factor bone marrow stromal antigen 2 (BST-2/tetherin) blocks the release of HIV-1 and other enveloped viruses.
Juan F. eArias, Yukie eIwabu, Kenzo eTokunaga   +2 more
doaj   +1 more source