Results 1 to 10 of about 1,056,606 (342)

First Molecular Characterization of sp. and sp. Isolated from Mangrove in Mexico and the Antagonist Effect of as an Effective Biocontrol Agent [PDF]

The Plant Pathology Journal, 2021
The aim of this study was to characterize potential fungal species affecting mangrove species in Mexico. The phytopathogens were identified based on morphological and molecular characteristics using internal transcribed spacer (ITS1/ITS4) primers then ...
Mayra I. Grano-Maldonado, Rosalio Ramos-Payan, Fernando Rivera-Chaparro, Maribel Aguilar-Medina, José Geovanni Romero-Quintana, Amparo Rodríguez-Santiago, Mario Nieves-Soto   +6 more
doaj   +1 more source

Human-Based Immune Responsive In Vitro Infection Models for Validation of Novel TLR4 Antagonists Identified by Computational Discovery

Microorganisms, 2022
Infectious diseases are still a major problem worldwide. This includes microbial infections, with a constant increase in resistance to the current anti-infectives employed. Toll-like receptors (TLRs) perform a fundamental role in pathogen recognition and
Helena Merk, Tehila Amran-Gealia, Doris Finkelmeier, Christina Kohl, Isabelle Pichota, Noa Stern, Steffen Rupp, Amiram Goldblum, Anke Burger-Kentischer   +8 more
doaj   +1 more source

Sleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors

Pharmaceutical Biology, 2022
Context The sleep-promoting activity of Nelumbo nucifera Gaertn. (Nymphaeaceae) alkaloids in leaves or seeds are well known. However, the sleep-promoting activity of the lotus rhizome (LE), which is used mainly as food, has not yet been evaluated ...
Yejin Ahn, Singeun Kim, Chunwoong Park, Jung Eun Kim, Hyung Joo Suh, Kyungae Jo   +5 more
doaj   +1 more source

Modern aspects in anesthesia of small laboratory animals

Южно-Российский онкологический журнал, 2022
Experiments with small laboratory animals are required for better understanding of a disease flow, for studying the mechanisms of it’s development and for the development of new therapeutic strategies.
S. V. Gurova, M. V. Mindar, D. V. Khodakova   +2 more
doaj   +1 more source

Intellectual Capital and Chaos of Innovation: Antagonist Coalition in Organizations

Istanbul Management Journal, 2023
As a critical resource of human capital, employees might be the leading supporters of innovation management considering the integrated intellectual capital.
Asiye Yüksel
doaj   +1 more source

Pyrrolotriazinone as an Underexplored Scaffold in Drug Discovery

Pharmaceuticals, 2021
Heterocyclic amino derivatives have been extensively synthesized and validated as potent bioactive compounds, and nowadays, numerous marketed drugs share these scaffolds, from very simple structures (monoamino, monocyclic compounds) to much more complex ...
Tony Ge, Jean-Christophe Cintrat
doaj   +1 more source

Inhibiting the P2X4 Receptor Suppresses Prostate Cancer Growth In Vitro and In Vivo, Suggesting a Potential Clinical Target

Cells, 2020
Prostate cancer (PCa) is the most frequently diagnosed cancer in men, causing considerable morbidity and mortality. The P2X4 receptor (P2X4R) is the most ubiquitously expressed P2X receptor in mammals and is positively associated with tumorigenesis in ...
Jiepei He, Yuhan Zhou, Hector M. Arredondo Carrera, Alexandria Sprules, Ramona Neagu, Sayyed Amin Zarkesh, Colby Eaton, Jian Luo, Alison Gartland, Ning Wang   +9 more
doaj   +1 more source

Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies

Frontiers in Endocrinology, 2023
Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. PRL is reported to play a role in pregnancy, mammary gland development, immune modulation, reproduction, and differentiation of islet cells. PRL binds to its receptor
David Standing, Prasad Dandawate, Shrikant Anant   +2 more
doaj   +1 more source

Targeting TNFR2 in Cancer: All Roads Lead to Rome

Frontiers in Immunology, 2022
TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs).
Jingchao Bai, Jingchao Bai, Jingchao Bai, Bowen Ding, Bowen Ding, Bowen Ding, Hui Li, Hui Li, Hui Li   +8 more
doaj   +1 more source

Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial [PDF]

International Journal of Fertility and Sterility
Background: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods.Thus, the need to investigate new methods is essential.
Fatemeh Ghahghayi, Abolfazl Payandeh, Aida Najafian, Marzieh Ghasemi, Ayob Jabari Jabari   +4 more
doaj   +1 more source