Results 1 to 10 of about 630,882 (146)
Frontiers in Endocrinology, 2016 Adrenocorticotropin (ACTH) acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R), is unusual in that it is absolutely dependent on a small accessory protein, melanocortin receptor accessory protein (MRAP) for
Clark, AJ +6 more
openaire +4 more sources
European Heart Journal, 2018 The current manuscript is the second update of the original Practical Guide, published in 2013 [Heidbuchel et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation ...
J. Steffel +25 more
semanticscholar +1 more source
New England Journal of Medicine, 2001 BACKGROUND It is unknown whether either the angiotensin-II-receptor blocker irbesartan or the calcium-channel blocker amlodipine slows the progression of nephropathy in patients with type 2 diabetes independently of its capacity to lower the systemic ...
E. Lewis +9 more
semanticscholar +1 more source
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Archives of General Psychiatry, 2006 CONTEXT Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are ...
C. Zarate +7 more
semanticscholar +1 more source
Mathématiques et sciences humaines, 2002 Certaines propriétés des jeux à somme nulle sont étendues à différentes classes de jeux à deux joueurs à somme non nulle. Les définitions de ces classes sont basées sur différentes notions d'antagonisme. La notion de jeux presque strictement compétitifs, introduite par Aumann en 1961, est généralisée en gardant l'unicité du paiement d'équilibre de Nash.
openaire +2 more sources
The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist
Science, 2008 The adenosine class of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) mediates the important role of extracellular adenosine in many physiological processes and is antagonized by caffeine.
Veli-Pekka Jaakola +7 more
semanticscholar +1 more source
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
Nature, 2012 Opium is one of the world’s oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These prototypical opioids produce analgesia as well as many undesirable side effects (sedation, apnoea and ...
A. Manglik +9 more
semanticscholar +1 more source
Human Reproduction Update, 2017 BACKGROUND Most reviews of IVF ovarian stimulation protocols have insufficiently accounted for various patient populations, such as ovulatory women, women with polycystic ovary syndrome (PCOS) or women with poor ovarian response, and have included ...
C. Lambalk +7 more
semanticscholar +1 more source
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2004 Ovarian stimulation is an important step in the success rate of in vitro fertilization (IVF) allowing multiple follicular growth, several oocytes and consequently more embryos. The combination of GnRH-antagonists (GnRH-ant) and gonadotrophins is now available for clinical use and represent a valid alternative to classical protocol with GnRH agonist ...
COCCIA, MARIA ELISABETTA +3 more
openaire +3 more sources
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Science, 2006 Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor–β (TGF-β) family
J. Habashi +19 more
semanticscholar +1 more source