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First Molecular Characterization of sp. and sp. Isolated from Mangrove in Mexico and the Antagonist Effect of as an Effective Biocontrol Agent [PDF]

The Plant Pathology Journal, 2021
The aim of this study was to characterize potential fungal species affecting mangrove species in Mexico. The phytopathogens were identified based on morphological and molecular characteristics using internal transcribed spacer (ITS1/ITS4) primers then ...
Mayra I. Grano-Maldonado, Rosalio Ramos-Payan, Fernando Rivera-Chaparro, Maribel Aguilar-Medina, José Geovanni Romero-Quintana, Amparo Rodríguez-Santiago, Mario Nieves-Soto   +6 more
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Filling the Gaps in Antagonist CCR5 Binding, a Retrospective and Perspective Analysis

Frontiers in Immunology, 2022
The large number of pathologies that position CCR5 as a central molecular determinant substantiates the studies aimed at understanding receptor-ligand interactions, as well as the development of compounds that efficiently block this receptor.
Yerkezhan Amerzhanova, Luca Vangelista
doaj   +1 more source

Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders

Frontiers in Pharmacology, 2021
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established.
Kotaro Sakamoto, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Teruaki Masutani, Kenji Ishimoto, Kenji Ishimoto, Kenji Ishimoto, Nobumasa Hino, Shinsaku Nakagawa, Shinsaku Nakagawa, Shinsaku Nakagawa, Satoshi Asano, Yukio Ago, Yukio Ago, Yukio Ago, Yukio Ago   +16 more
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Design, synthesis and biological evaluation of novel biphenylsulfonamide derivatives as selective AT2 receptor antagonists

Frontiers in Chemistry, 2022
A novel series of benzenesulfonamide derivatives that selectively act on the AT2 receptor have been designed and synthesized. The binding affinity and functional activity were evaluated by radio-ligand binding analysis and cell neurite outgrowth assay ...
Danhui Wang, Wenjie Zhao, Zuzhi Zhang, Yanchun Zhang, Yanchun Zhang, Jiaming Li, Jiaming Li, Weijun Huang   +7 more
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Sleep-promoting activity of lotus (Nelumbo nucifera) rhizome water extract via GABAA receptors

Pharmaceutical Biology, 2022
Context The sleep-promoting activity of Nelumbo nucifera Gaertn. (Nymphaeaceae) alkaloids in leaves or seeds are well known. However, the sleep-promoting activity of the lotus rhizome (LE), which is used mainly as food, has not yet been evaluated ...
Yejin Ahn, Singeun Kim, Chunwoong Park, Jung Eun Kim, Hyung Joo Suh, Kyungae Jo   +5 more
doaj   +1 more source

Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies

Frontiers in Endocrinology, 2023
Prolactin (PRL) is a peptide hormone mainly secreted from the anterior pituitary gland. PRL is reported to play a role in pregnancy, mammary gland development, immune modulation, reproduction, and differentiation of islet cells. PRL binds to its receptor
David Standing, Prasad Dandawate, Shrikant Anant   +2 more
doaj   +1 more source

Targeting TNFR2 in Cancer: All Roads Lead to Rome

Frontiers in Immunology, 2022
TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs).
Jingchao Bai, Jingchao Bai, Jingchao Bai, Bowen Ding, Bowen Ding, Bowen Ding, Hui Li, Hui Li, Hui Li   +8 more
doaj   +1 more source

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

Frontiers in Immunology, 2022
A2A receptors (A2AR), a typical GPCR with a high affinity for adenosine, was expressed in many immune cells, such as regulatory T cells, cytotoxic T cells, macrophages, etc.
Changfa Sun, Bochu Wang, Shilei Hao
doaj   +1 more source

Development of tolerance to chemokine receptor antagonists: current paradigms and the need for further investigation

Frontiers in Immunology, 2023
Chemokine G-protein coupled receptors are validated drug targets for many diseases, including cancer, neurological, and inflammatory disorders. Despite much time and effort spent on therapeutic development, very few chemokine receptor antagonists are ...
Patrick Grudzien, Henry Neufeld, Mbasogo Ebe Eyenga, Vadim Gaponenko   +3 more
doaj   +1 more source

Inhibitory effects of antagonistic bacteria inhabiting the rhizosphere of the sugarbeet plants, on Cercospora beticola Sacc., the causal agent of Cercospora leaf spot disease on sugarbeet

Journal of Plant Protection Research, 2016
In the present study, the antagonistic capability of bacterial agents inhabiting the rhizosphere of sugarbeet plants were evaluated against Cercospora beticola Sacc. under laboratory and greenhouse conditions.
Arzanlou Mahdi, Mousavi Somayeh, Bakhshi Mounes, Khakvar Reza, Bandehagh Ali   +4 more
doaj   +1 more source