Results 91 to 100 of about 1,056,606 (342)

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold [PDF]

, 2018
Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector Gli1 have thus emerged ...
Bruno Botta, Cinzia Ingallina, Elisa De Paolis, Flavia Bernardi, Francesca Ghirga, Isabella Romeo, Lucia Di Marcotullio, Mattia Mori, Miriam Caimano, Paola Infante, Romina Alfonsi, Sara Toscano, Simone Berardozzi   +12 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Structure-based analysis of the ultraspiracle protein and docking studies of putative ligands

Journal of Insect Science, 2002
The ultraspiracle protein (USP) is the insect ortholog of the mammalian retinoid X receptor (RXR). Fundamental questions concern the functional role of USP as the heterodimerization partner of insect nuclear receptors such as the ecdysone receptor.
Souphatta Sasorith, Isabelle M.L. Billas, Thomas Iwema, Dino Moras, Jean-Marie Wurtz   +4 more
doaj  

The Effect of Combined Application of Biocontrol Microorganisms and Arbuscular Mycorrhizal Fungi on Plant Growth and Yield of Tomato (Solanum lycopersicum L.)

Agriculture
Sustainable plant production requires less use of synthetic chemicals in plant nutrition and protection. Microbial products are among the most promising substitutes for chemicals.
Alaa Abdulkadhim A. Almuslimawi, Borbála Kuchár, Susana Estefania Araujo Navas, György Turóczi, Katalin Posta   +4 more
doaj   +1 more source

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists [PDF]

, 2023
Claudia Finamore, Carmen Festa, Bianca Fiorillo, Francesco Saverio Di Leva, Rosalinda Roselli, Silvia Marchianò, Michele Biagioli, Lucio Spinelli, Stefano Fiorucci, Vittorio Limongelli, Angela Zampella, Simona De Marino   +11 more
openalex   +1 more source

Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse [PDF]

, 2003
We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket ...
Dean, I., Edwards, F.A., Robertson, S.J.
core  

Cisplatin-induced emesis: systematic review and meta-analysis of the ferret model and the effects of 5-HT3 receptor antagonists [PDF]

, 2010
PURPOSE: The ferret cisplatin emesis model has been used for ~30 years and enabled identification of clinically used anti-emetics. We provide an objective assessment of this model including efficacy of 5-HT(3) receptor antagonists to assess its ...
A Fink-Jensen, A Lehmann, A Ozaki, AG King, AH Lau, AL Harris, AM Holmes, AP Florczyk, AP Florczyk, B Costall, B Costall, B Costall, B Costall, B Costall, B Costall, B Lasheras, C Bountra, C. C. Apfel, CJ Gardner, CJ Gardner, CJ Gardner, CL Gooch, D Moher, D Spina, D Tattersall, D Tattersall, DG Altman, DJ Reynolds, DR Gandara, E Blum, E Chevalier, F Roila, FD Tattersall, FD Tattersall, FD Tattersall, GA Higgins, GJ Hollingworth, H Nakayama, H Yamakuni, H Yamakuni, HE Marr, HE Marr, HE Marr, HL Borison, I Angel, I Monkovic, IT Jantunen, J Bermudez, J Hawthorn, J Horn, J Horn, J. A. Rudd, JA Gylys, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JA Rudd, JE Schurig, JH Kim, JJ Hale, JJ Hale, JM Barnes, JN Matthews, JW Watson, K Haga, K Haga, L Singh, LE McCarthy, LR Fitzpatrick, LX Cubeddu, M Martin, M Marty, M Minami, M Minami, M Minami, M Ohta, M Tsuchiya, MD Sickle Van, MG Kris, MG Kris, MR Macleod, MR Macleod, MR Macleod, MT Price, N Fukunaka, N Percie du Sert, N Yoshida, N Yoshida, N Yoshida, N Yoshida, N. Percie du Sert, NM Barnes, NM Barnes, NM Rupniak, P Bhandari, P Delagrange, P Pound, P Preziosi, P Ruff, P. L. R. Andrews, PJ Hesketh, PJ Hesketh, PLR Andrews, PLR Andrews, PR Blower, R DerSimonian, R Hargreaves, R Stables, RA Matthews, RC Miller, RD Clark, RD Youssefyeh, RD Youssefyeh, RM Eglen, RM Eglen, RM Eglen, RM Navari, S Bingham, S Gonsalves, S Taniguchi, T Endo, T Endo, T Endo, T Endo, T Endo, T Ito, T Kamato, T Kamato, T Matsui, T Yoshikawa, T Yoshikawa, T Yoshikawa, TM Dando, TS Sam, TS Sam, TS Sam, V Bebarta, WD Miner, WD Miner, WD Miner, Y Kubota, Y Shiroshita, Y Shiroshita, Y Watanabe, YL Liu   +153 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

THE ANTIFUNGAL ACTIVITY OF ENDOPHYTE FUNGUS FROM RUBBER LEAVES IN VITRO AND ITS ANTAGONIST MECHANISM OF COLLETOTRICHUM GLOEOSPORIOIDES

Russian Journal of Agricultural and Socio-Economic Sciences, 2021
Rubber tree disease is the most important disturbing factor compared to other disorders. There have been found 25 types of diseases in rubber estate, and the most important one is Colletotrichum leaf spot caused by Colletotrichum gloesporioides. Recently,
Syamsafitri, Bakti D., Lisnawita, Tistama R.   +3 more
doaj   +1 more source