Results 91 to 100 of about 1,052,930 (370)
FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, Volume 599, Issue 9, Page 1260-1268, May 2025.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Plant Protection Science, 2005 The Rosy rustic moth (Hydraecia micacea) has been a pest of hop in Czech hop regions for a long time. It causes most severe damages in hop gardens infested by quackgrass (Elytrigia repens) on waterlogged areas. Larvae emerge from the second half of April
Josef Šedivý +2 more
doaj +1 more source
Altruism and Antagonistic Pleiotropy in Penna Ageing Model [PDF]
arXiv, 2004 The Penna ageing model is based on mutation accumulation theory. We show that it also allows for self-organization of antagonistic pleiotropy which helps at young age at the expense of old age. This can be interpreted as emergence of altruism.
arxiv
FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang +9 more
wiley +1 more source
Archives of General Psychiatry, 2010 CONTEXT Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and ...
N. Diazgranados +12 more
semanticscholar +1 more source
Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells
Biology, 2017 We previously reported that raloxifene, an estrogen receptor modulator, is also a ligand for the aryl hydrocarbon receptor (AhR). Raloxifene induces apoptosis in estrogen receptor-negative human cancer cells through the AhR.
Hyo Sang Jang +9 more
doaj +1 more source
FEBS Letters, Volume 599, Issue 6, Page 876-891, March 2025.We explore 5HT2A receptor activation, a key target for psychedelic drugs, using molecular dynamics simulations. Without Gqα, the active receptor collapses to an inactive conformation, underscoring the G‐protein's role. Discovery of an intermediate “partially‐open” state and the higher affinity of ligands to the orthosteric binding site provides ...
Niklas Viohl +2 more
wiley +1 more source
Thrombin-receptor antagonist vorapaxar in acute coronary syndromes.
New England Journal of Medicine, 2012 BACKGROUND Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients
P. Tricoci +41 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source