Results 111 to 120 of about 1,513,260 (338)

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. [PDF]

open access: yes, 2019
Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear ...
Bold, Richard J   +21 more
core  

Targeting renal cell carcinoma with a HIF-2 antagonist

open access: yesNature, 2016
Wen-fang Chen   +33 more
semanticscholar   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

open access: yesScience, 2008
Veli-Pekka Jaakola   +7 more
semanticscholar   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Observations on the effects of the folic acid antagonists, aminopterin and amethopterin, in patients with advanced neoplasms [PDF]

open access: bronze, 1952
Emanuel B. Schoenbach   +2 more
openalex   +1 more source

GnRH antagonist versus long agonist protocols in IVF: a systematic review and meta-analysis accounting for patient type

open access: yesHuman Reproduction Update, 2017
C. Lambalk   +7 more
semanticscholar   +1 more source

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