Results 141 to 150 of about 647,962 (308)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Gait analysis in cerebral stroke with the agonist-antagonist EMG ratio Method

open access: yes, 2001
Agonist-Antagonist EMG Ratio Methodを用いて,歩行周期内の前脛骨筋(tibialis anterior:TA)と下腿三頭筋(triceps surae:TS)の活動変化をTA-TS correlationgramとして視覚的にとらえることができた.健常者は双曲線様カーブを描き,脳卒中患者の立脚期を4群に分類した.A群:前半はTA優位からTS優位へ,後半はTA優位へ戻る.相反性抑制が保たれ健常者に近い.B群:前半は緊張性相反性抑制のためTAは変化せずTSだけが増減し ...
井口, 茂   +2 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Casopitant: a novel NK1-receptor antagonist in the prevention of chemotherapy-induced nausea and vomiting

open access: yes, 2009
Christina Ruhlmann, Jørn HerrstedtOdense University Hospital, Department of Oncology, Odense, DenmarkAbstract: Chemotherapy-induced nausea and vomiting (CINV) are among the most feared and distressing symptoms experienced by patients with ...
Christina Ruhlmann   +1 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Cyanide antagonist [PDF]

open access: yesCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1981
C J, Vesey, P V, Cole
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Pain Intensity in Patients with Opioid Use Disorder on Extended-Release Naltrexone or Opioid Agonists; The Role of COMT rs4680 and OPRM1 rs1799971: An Exploratory Study

open access: yesJournal of Pain Research
Farid Juya,1 Ann Christin Sannes,2,3 Kristin Klemmetsby Solli,1,2,4 Bente Weimand,2,4 Johannes Gjestad,2,5 Lars Tanum,2,3 Jon Mordal1 1Division of Mental Health and Addiction, Vestfold Hospital Trust, Tønsberg, Norway; 2Mental Health Services, Akershus ...
Juya F   +6 more
doaj  

Home - About - Disclaimer - Privacy