Results 171 to 180 of about 471,515 (268)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Cortically Mediated Muscle Responses to Balance Perturbations Increase with Perturbation Magnitude in Older Adults with and without Parkinson's Disease. [PDF]

eNeuro
Boebinger SE, Payne AM, Xiao J, Martino G, Borich MR, Lucas McKay J, Ting LH.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

RETRACTED: Cavalu et al. Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol Against Gram-Negative Bacterial Pathogens. <i>Int. J. Mol. Sci.</i> 2022, <i>23</i>, 13088. [PDF]

Int J Mol Sci
Cavalu S, Elbaramawi SS, Eissa AG, Radwan MF, Ibrahim TS, Khafagy ES, Lopes BS, Ali MAM, Hegazy WAH, Elfaky MA.   +9 more
europepmc   +1 more source

Amino-Acid-Derived Androgen Receptor Modulators. [PDF]

ACS Med Chem Lett
Semenya J, Picazo E.
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Addition of Clomiphene Citrate to a Low-Dose Gonadotropin-Releasing Hormone (GnRH)-Antagonist Protocol in Poor Responders: A Prospective Cohort Study. [PDF]

Cureus
Triantafyllidou O, Panagodimou E, Chasiakou S, Gkontelos A, Karkalemis K, Simopoulou M, Tzanakaki D, Syggelos N, Kalampokas T, Vakas P, Lazaridis A, Vlahos F, Christopoulos P, Vlahos N.   +13 more
europepmc   +1 more source

The therapeutic potential of local injection of leptin for periodontitis in rats: an investigation based on the OPG/RANKL mechanism. [PDF]

BMC Oral Health
Guo Z, Hu Q, Li H, Liu N, Liu Q.
europepmc   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

A novel fusion tool to enable G protein-coupled receptor structure determination. [PDF]

Acta Crystallogr D Struct Biol
Shah NR, Oosterlaken M, Bisson C, Bertinelli M, Churchill-Angus AM, Hutchin A, Kopec J, Kotov V, McFarlane CR, Griss Pascualli E, Pavic A, Zebisch M, Fiez-Vandal C, Fabini E, Duclos S.   +14 more
europepmc   +1 more source