Results 31 to 40 of about 1,549,522 (343)

The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects [PDF]

, 2015
Funded by: •GW Pharmaceuticals Acknowledgements: The authors wish to thank Mrs Lesley Stevenson for technical support and Dr John Raymond, Dr Keith Parker and Dr Ethan Russo for providing human 5-HT1A CHO cells.
Cascio, Maria Grazia, Marini, Pietro, Parolaro, Daniela, Pertwee, Roger G., Zamberletti, Erica   +4 more
core   +1 more source

Métodos semiempíricos para la evaluación rápida de orbitales frontera en la clasificación de agonistas y antagonistas de la subunidad NR1 de los receptores iGluR-NMDA

Universitas Scientiarum, 2010
Los receptores iGluR-NMDAposeen gran interés farmacológico debido a que están implicadosen desordenes neurodegenerativos y neurosiquiátricos inclusoparticipan en procesos como plasticidad sináptica, esencial para la formación de la memoria.
Juvenal Yosa-Reyes, Diana Carolina Clavijo-Buriticá, Carlos Manuel Estévez-Bretón Riveros, Orlando Emilio Acevedo   +3 more
doaj   +1 more source

Microbes vs. Nematodes: Insights into Biocontrol through Antagonistic Organisms to Control Root-Knot Nematodes

Plants, 2023
Root-knot nematodes (Meloidogyne spp.) are sedentary endoparasites that cause severe economic losses to agricultural crops globally. Due to the regulations of the European Union on the application of nematicides, it is crucial now to discover eco ...
Adil Ameen Bhat, Adnan Shakeel, Sonia Waqar, Zafar Ahmad Handoo, Abrar Ahmed Khan   +4 more
doaj   +1 more source

Antagonists of Evil in the Works of J. R. R. Tolkien and Nato Davitashvili

Nalans, 2021
The article deals with the main characteristics of the antagonists in Fantasy literature. Evil characters have always existed in different literary works. However, in fantasy literature the main antagonist is definitely evil.
Tamar Katamadze
doaj  

Orexin-Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine [PDF]

, 2015
Release of the neuropeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) play an important role in stress-induced cocaine-seeking behavior.
Aguinaga, David, Cai, Ning-Sheng, Canela, Enric I, Casadó, Vicent, Cortés, Antonio, Ferré, Sergi, Hausch, Felix, Howell, Lesley A., Lluís, Carme, Mallol, Josefa, McCormick, Peter J., McDowell, Kimberly, Moreno, Estefanía, Moreno-Delgado, David, Navarro, Gemma, Quiroz, César, Rea, William, Sierakowiak, Adam   +17 more
core   +1 more source

THE ANTIFUNGAL ACTIVITY OF ENDOPHYTE FUNGUS FROM RUBBER LEAVES IN VITRO AND ITS ANTAGONIST MECHANISM OF COLLETOTRICHUM GLOEOSPORIOIDES

Russian Journal of Agricultural and Socio-Economic Sciences, 2021
Rubber tree disease is the most important disturbing factor compared to other disorders. There have been found 25 types of diseases in rubber estate, and the most important one is Colletotrichum leaf spot caused by Colletotrichum gloesporioides. Recently,
Syamsafitri, Bakti D., Lisnawita, Tistama R.   +3 more
doaj   +1 more source

Emergence of an Auxin Sensing Domain in Plant-Associated Bacteria

mBio, 2023
Bacteria have evolved a sophisticated array of signal transduction systems that allow them to adapt their physiology and metabolism to changing environmental conditions. Typically, these systems recognize signals through dedicated ligand binding domains (
José A. Gavira, Miriam Rico-Jiménez, Álvaro Ortega, Natalia V. Petukhova, Dmitrii S. Bug, Albert Castellví, Yuri B. Porozov, Igor B. Zhulin, Tino Krell, Miguel A. Matilla   +9 more
doaj   +1 more source

Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice [PDF]

, 2008
Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not
Atkins, Baik, Battisti, Battisti, Boileau, Cador, Chiang, Crabbe, Crawford, de Wit, Down, Fleckenstein, Gabbay, Glickstein, Hamamura, Jones, Kalivas, Kamens, Karler, Karper, Kelly, Kelly, Kilty, Kuczenski, Kuribara, Kuribara, Kuribara, McDougall, Neve, Palmer, Phillips, Phillips, Pierce, Robinson, Ron, Rubinstein, Sax, Schmauss, Shen, Tanabe, Ujike, Vezina, Vezina, Xu, Xu, Xu, Xu, Yates   +47 more
core   +1 more source

Effects of vedolizumab induction therapy for patients with Crohn's disease in whom tumor necrosis factor antagonist treatment failed.

Gastroenterology, 2014
BACKGROUND & AIMS There is an increasing need for new treatments for patients with Crohn's disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has failed.
B. Sands, B. Feagan, P. Rutgeerts, J. Colombel, W. Sandborn, R. Sy, G. D'Haens, S. Ben-Horin, Jing Xu, M. Rosario, I. Fox, A. Parikh, C. Milch, S. Hanauer   +13 more
semanticscholar   +1 more source

Endemic Jeffrey Pine Beetle Associates: Beetle/Mite Fungal Dissemination Strategies and Interactions That May Influence Beetle Population Levels

Microorganisms, 2021
Fungal and mite associates may drive changes in bark beetle populations, and mechanisms constraining beetle irruptions may be hidden in endemic populations.
Javier E. Mercado, Beatriz Ortiz-Santana, Shannon L. Kay   +2 more
doaj   +1 more source