Results 31 to 40 of about 1,028,152 (221)

A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial.

Journal of the American Medical Association (JAMA), 2003
CONTEXT Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials ...
C. Pepine, E. Handberg, R. Cooper-DeHoff, R. Marks, P. Kowey, F. Messerli, G. Mancia, J. Cangiano, D. García-Barreto, M. Keltai, S. Erdine, Heather A. Bristol, Ms H Robert Kolb, G. Bakris, Jerome D. Cohen, W. Parmley   +15 more
semanticscholar   +1 more source

Inferring Synergistic and Antagonistic Interactions in Mixtures of Exposures [PDF]

arXiv, 2022
There is abundant interest in assessing the joint effects of multiple exposures on human health. This is often referred to as the mixtures problem in environmental epidemiology and toxicology. Classically, studies have examined the adverse health effects of different chemicals one at a time, but there is concern that certain chemicals may act together ...
arxiv  

Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

Journal of Experimental Medicine, 2005
Improving approaches for hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) mobilization is clinically important because increased numbers of these cells are needed for enhanced transplantation. Chemokine stromal cell derived factor-1 (
H. Broxmeyer, Christie M Orschell, D. Clapp, G. Hangoc, S. Cooper, P. Plett, W. C. Liles, Xiaxin Li, B. Graham-Evans, Timothy B. Campbell, G. Calandra, G. Bridger, David C. Dale, E. Srour   +13 more
semanticscholar   +1 more source

Endothelin Receptors and Their Antagonists

Seminars in Nephrology, 2015
All three members of the endothelin (ET) family of peptides, ET-1, ET-2, and ET-3, are expressed in the human kidney, with ET-1 being the predominant isoform. ET-1 and ET-2 bind to two G-protein-coupled receptors, ETA and ETB, whereas at physiological concentrations ET-3 has little affinity for the ET(A) receptor.
Maguire, Janet J, Davenport, Anthony P
openaire   +4 more sources

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Science, 2010
Tweaking Dopamine Reception Dopamine modulates many cognitive and emotional functions of the human brain by activating G protein–coupled receptors. Antipsychotic drugs that block two of the receptor subtypes are used to treat schizophrenia but have ...
E. Chien, Wei Liu, Qiang Zhao, V. Katritch, Gye Won Han, M. Hanson, Lei Shi, A. Newman, J. Javitch, V. Cherezov, R. Stevens   +10 more
semanticscholar   +1 more source

Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]

World Journal of Research and Review (WJRR) ISSN:2455-3956, Volume-4, Issue-5, May 2017 Pages 26-30, 2020
Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv  

Opinion Formation under Antagonistic Influences [PDF]

Phys. Rev. E 100, 050301 (2019), 2019
We study the opinion dynamics in a generalized voter model in which voters are additionally influenced by two antagonistic news sources, whose effect is to promote political polarization. We show that, as the influence of the news sources is increased, the mean time to reach consensus is anomalously long, the time to reach a politically polarized state
arxiv   +1 more source

A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression.

Archives of General Psychiatry, 2010
CONTEXT Existing therapies for bipolar depression have a considerable lag of onset of action. Pharmacological strategies that produce rapid antidepressant effects-for instance, within a few hours or days-would have an enormous impact on patient care and ...
N. Diazgranados, Lobna A Ibrahim, N. Brutsche, Andrew R Newberg, Phillip Kronstein, S. Khalifé, W. Kammerer, Z. Quezado, D. Luckenbaugh, G. Salvadore, R. Machado-Vieira, H. Manji, C. Zarate   +12 more
semanticscholar   +1 more source

Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.

New England Journal of Medicine, 2011
BACKGROUND Generalized pustular psoriasis is a life-threatening disease of unknown cause. It is characterized by sudden, repeated episodes of high-grade fever, generalized rash, and disseminated pustules, with hyperleukocytosis and elevated serum levels ...
S. Marrakchi, P. Guigue, B. Renshaw, A. Puel, X. Pei, S. Fraitag, J. Zribi, E. Bal, C. Cluzeau, M. Chrabieh, J. Towne, Jason Douangpanya, C. Pons, Sourour Mansour, V. Serre, H. Makni, N. Mahfoudh, F. Fakhfakh, C. Bodemer, J. Feingold, S. Hadj-Rabia, M. Fãvre, E. Génin, M. Sahbatou, A. Munnich, J. Casanova, J. Sims, H. Turki, H. Bachelez, A. Smahi   +29 more
semanticscholar   +1 more source

Thrombin-receptor antagonist vorapaxar in acute coronary syndromes.

New England Journal of Medicine, 2012
BACKGROUND Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. METHODS In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients
P. Tricoci, Zhen Huang, C. Held, D. Moliterno, P. Armstrong, F. Van de Werf, H. White, P. Aylward, L. Wallentin, E. Chen, Y. Lokhnygina, J. Pei, S. Leonardi, Tyrus L. Rorick, A. Kilian, L. Jennings, G. Ambrosio, C. Bode, Á. Cequier, J. Cornel, R. Diaz, A. Erkan, K. Huber, M. Hudson, Lixin Jiang, J. Jukema, B. Lewis, A. Lincoff, G. Montalescot, J. Nicolau, H. Ogawa, M. Pfisterer, J. Prieto, W. Rużyłło, P. Sinnaeve, R. Storey, M. Valgimigli, D. Whellan, P. Widimsky, J. Strony, R. Harrington, K. Mahaffey   +41 more
semanticscholar   +1 more source