Results 41 to 50 of about 1,519,714 (391)
Actinobacteria from the rhizosphere of agricultural crops are a potential source of antagonists against phytopathogenic microorganisms. Thus, the objective of this study was to characterize the antagonistic activity in vitro of actinobacteria from the ...
Jesús Rafael Trinidad-Cruz+6 more
doaj +1 more source
Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê+86 more
core +3 more sources
Epilepsy is a severe brain disorder affecting numerous patients. Recently, it is inferred that modulation of microRNA-155 (miR-155) could serve as a promising treatment of mesial temporal lobe epilepsy (MTLE).
Zhengxu eCai+11 more
doaj +1 more source
The electromyography (EMG) cocontraction index (CCI) given by the antagonistic/agonistic Root Mean Square (RMS) amplitude ratio of the same muscle is a qualified biomarker used for spastic cocontraction quantification and management in cerebral palsy ...
Maria Vinti+5 more
doaj +1 more source
Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands [PDF]
Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled Free Fatty Acid 2 (FFA2) receptor and this has been suggested as a therapeutic ...
Hansen, Anders Højgaard+6 more
core +1 more source
Pharmacological characterization of rat paw edema induced by Cerastes gasperettii (cerastes) venom
Inflammatory response induced by the venom of the Arabian sand viper Cerastes gasperettii was studied by measuring rat hind-paw edema. Cerastes gasperettii venom (CgV, 3.75-240 µg/paw), heated for 30s at 97°C, caused a marked dose and time-dependent ...
A. K. Al-Asmari, N. M. Abdo
doaj +1 more source
Interactions of narcotic antagonists and antagonist-analgesics
Abstract In the rat the potent narcotic antagonist N-cyclopropylmethyl-6,14-endoethano-7α- (1-hydroxy-1-methylethyl)-tetrahydronororipavine (M5050, Reckitt), which itself lacks analgesic activity, resembled naloxone in its capacity to reverse the antinociceptive effects of morphine antagonist-analgesics. The nociceptive stimulus employed
G F Blane, D Dugdall
openaire +3 more sources
Antagonists to the rescue [PDF]
Errors in protein folding represent the underlying basis for a large number of genetically inherited diseases. Point mutations, deletions, and in some cases, expanded sequences of amino acids give rise to protein products that fail to reach their native folded state.
Marybeth Howard, William J. Welch
openaire +3 more sources
5-Hydroxytryptamine type 2A (5-HT2A) receptor is an important target for developing innovative antipsychotic agents in neuropsychiatric disorder therapies.
Lijian Ding+8 more
doaj +1 more source
Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng+7 more
doaj +1 more source