Results 41 to 50 of about 1,549,522 (343)

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release [PDF]

, 2007
We investigated the effect of the glucocorticoid receptor (GR) antagonist Org 34850 on fast and delayed inhibition of corticosterone secretion in response to the synthetic glucocorticoid methylprednisolone (MPL).
Craighead, Mark, Grassie, Morag, Harrison, Louse R., Lightman, Stafford L., MacSweeney, Cliona P., Spiga, Francesca, Thomson, Fiona .J., Wood, Susan A.   +7 more
core   +1 more source

Investigating Ovulation Induction Outcomes in Patients with Decreased Ovarian Reserve Treated with Double Stimulation during The Follicular and Luteal Phases Compared to The Conventional Antagonist Cycle: A Randomized Clinical Trial [PDF]

International Journal of Fertility and Sterility
Background: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods.Thus, the need to investigate new methods is essential.
Fatemeh Ghahghayi, Abolfazl Payandeh, Aida Najafian, Marzieh Ghasemi, Ayob Jabari Jabari   +4 more
doaj   +1 more source

Design, synthesis and biological evaluation of novel biphenylsulfonamide derivatives as selective AT2 receptor antagonists

Frontiers in Chemistry, 2022
A novel series of benzenesulfonamide derivatives that selectively act on the AT2 receptor have been designed and synthesized. The binding affinity and functional activity were evaluated by radio-ligand binding analysis and cell neurite outgrowth assay ...
Danhui Wang, Wenjie Zhao, Zuzhi Zhang, Yanchun Zhang, Yanchun Zhang, Jiaming Li, Jiaming Li, Weijun Huang   +7 more
doaj   +1 more source

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

Cannabinoid Receptor Involvement in Stress-Induced Cocaine Reinstatement: Potential Interaction with Noradrenergic Pathways [PDF]

, 2012
This study examined the role of endocannabinoid signaling in stress-induced reinstatement of cocaine seeking and explored the interaction between noradrenergic and endocannabinergic systems in the process.
Hillard, Cecilia J., Kreutter, M., LaCourt, M., Mantsch, John R., Stroh, G., Vaughn, Linda K., Vranjkovic, Oliver   +6 more
core   +2 more sources

SPA70 is a potent antagonist of human pregnane X receptor

Nature Communications, 2017
Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70
Wenwei Lin, Yue‐ming Wang, S. Chai, L. Lv, Jie Zheng, Jing Wu, Qijun Zhang, Yong-Dong Wang, P. Griffin, Taosheng Chen   +9 more
semanticscholar   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Antagonist conditioning contractions impair agonist functioning [PDF]

, 2010
This study assessed the effect of antagonist conditioning contractions (ACC) on the subsequent force and electromyography of an agonist. Twelve subjects performed isokinetic elbow flexion on a dynamometer in 4 test conditions including a baseline ...
Ebben, William, Fauth, McKenzie, Garceau, Luke, Gray, Aaron, Hanson, Phillip, Hsu, Brittni, Lutsch, Brittney, Szalkowski, Chris, Yoon, Tejin   +8 more
core   +2 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Actions of agonists and antagonists of the ghrelin/GHS-R pathway on GH secretion, appetite and cFos activity

Frontiers in Endocrinology, 2013
The stimulatory effects of ghrelin, a 28-AA acylated peptide originally isolated from stomach, on GH secretion and feeding are exclusively mediated through the growth hormone secretagogue 1a receptor (GHS-R1a), the only ghrelin receptor described so far.
Rim eHassouna, Alexandra eLabarthe, Philippe eZizzari, Catherine eVideau, Michael D Culler, Jacques eEpelbaum, Virginie eTolle   +6 more
doaj   +1 more source