Results 41 to 50 of about 1,028,152 (221)
Altruism and Antagonistic Pleiotropy in Penna Ageing Model [PDF]
arXiv, 2004 The Penna ageing model is based on mutation accumulation theory. We show that it also allows for self-organization of antagonistic pleiotropy which helps at young age at the expense of old age. This can be interpreted as emergence of altruism.
arxiv
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
Nature, 2011 The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves.
K. Haga +10 more
semanticscholar +1 more source
Interleukin-1-receptor antagonist in type 2 diabetes mellitus.
New England Journal of Medicine, 2007 BACKGROUND The expression of interleukin-1-receptor antagonist is reduced in pancreatic islets of patients with type 2 diabetes mellitus, and high glucose concentrations induce the production of interleukin-1beta in human pancreatic beta cells, leading ...
C. Larsen +7 more
semanticscholar +2 more sources
Molecular Pharmacology, 2014 The tryptophan metabolites indole, indole-3-acetate, and tryptamine were identified in mouse cecal extracts and fecal pellets by mass spectrometry.
U. Jin +8 more
semanticscholar +1 more source
An Unusual Antagonistic Pleiotropy in the Penna Model for Biological Ageing [PDF]
, 2001 We combine the Penna Model for biological aging, which is based on the mutation-accumulation theory, with a sort of antagonistic pleiotropy. We show that depending on how the pleiotropy is introduced, it is possible to reproduce both the humans mortality, which increases exponentially with age, and fruitfly mortality, which decelerates at old ages ...
arxiv +1 more source
HYPERTENSION, 2004 —The metabolic syndrome is a common precursor of cardiovascular disease and type 2 diabetes that is characterized by the clustering of insulin resistance, dyslipidemia, and increased blood pressure.
S. Benson +9 more
semanticscholar +1 more source
A possible new phase of antagonistic nematogens in a disorienting field [PDF]
, 2003 A simple model is proposed for nematogenic molecules that favor perpendicular orientations as well as parallel ones. (Charged rods, for example, show this antagonistic tendency.) When a small disorienting field is applied along $z$, a low density phase $N_-$ of nematic order parameter $S_z<0$ coexists with a dense biaxial nematic $N_b$. (At zero field,
arxiv +1 more source
New England Journal of Medicine, 2004 BACKGROUND Calcitonin gene-related peptide (CGRP) may have a causative role in migraine. We therefore hypothesized that a CGRP-receptor antagonist might be effective in the treatment of migraine attacks. METHODS In an international, multicenter, double-
J. Olesen +7 more
semanticscholar +1 more source
Turbulent mixing controls fixation of growing antagonistic populations [PDF]
PNAS 122 (7) e2417075122 (2025)Unlike coffee and cream that homogenize when stirred, growing micro-organisms (e.g., bacteria, baker's yeast) can actively kill each other and avoid mixing. How do such antagonistic interactions impact the growth and survival of competing strains, while being spatially advected by turbulent flows? By using numerical simulations of a continuum model, we
arxiv +1 more source
What Is Antagonistic Pleiotropy? [PDF]
Biochemistry (Moscow), 2018 Antagonistic Pleiotropy has been the dominant theory for evolution of aging since it was first proposed 60 years ago. Indeed, examples of pleiotropy have been observed, but there are also many examples of mutations that lead to longer lifespan without apparent cost.
openaire +3 more sources