Results 51 to 60 of about 1,481,945 (415)
Extreme antagonism arising from gene-environment interactions [PDF]
, 2020 Antagonistic interactions in biological systems, which occur when one perturbation blunts the effect of another, are typically interpreted as evidence that the two perturbations impact the same cellular pathway or function. Yet, this interpretation ignores extreme antagonistic interactions wherein an otherwise deleterious perturbation compensates for ...
arxiv +1 more source
Interactions of narcotic antagonists and antagonist-analgesics
Journal of Pharmacy and Pharmacology, 1968 Abstract In the rat the potent narcotic antagonist N-cyclopropylmethyl-6,14-endoethano-7α- (1-hydroxy-1-methylethyl)-tetrahydronororipavine (M5050, Reckitt), which itself lacks analgesic activity, resembled naloxone in its capacity to reverse the antinociceptive effects of morphine antagonist-analgesics. The nociceptive stimulus employed
G F Blane, D Dugdall
openaire +3 more sources
Proceedings of the National Academy of Sciences, 1974 Structural modifications within the active site of the ACTH molecule have produced analogs that inhibit the hormone sensitive adenylate cyclase system of bovine adrenal cortical plasma membranes. It is demonstrated that the tryptophan residue of the ACTH molecule is essential for stimulation of the enzyme.
Klaus Hofmann +2 more
openaire +3 more sources
Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake [PDF]
, 2006 Repeated administration of abused drugs sensitizes their stimulant effects and results in a drug-paired environment eliciting conditioned activity. We tested whether food induces similar effects.
Le Merrer, Julie, Stephens, David N
core +1 more source
Emotional Contagion-Aware Deep Reinforcement Learning for Antagonistic Crowd Simulation [PDF]
arXiv, 2021 The antagonistic behavior in the crowd usually exacerbates the seriousness of the situation in sudden riots, where the antagonistic emotional contagion and behavioral decision making play very important roles. However, the complex mechanism of antagonistic emotion influencing decision making, especially in the environment of sudden confrontation, has ...
arxiv
Gastroenterology, 2014 BACKGROUND & AIMS There is an increasing need for new treatments for patients with Crohn's disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has failed.
B. Sands +13 more
semanticscholar +1 more source
Structural basis for the antiviral activity of BST-2/tetherin and its viral antagonism
Frontiers in Microbiology, 2011 The interferon-inducible host restriction factor bone marrow stromal antigen 2 (BST-2/tetherin) blocks the release of HIV-1 and other enveloped viruses.
Juan F. eArias +2 more
doaj +1 more source
Structure, Function, and Pharmaceutical Ligands of 5-Hydroxytryptamine 2B Receptor
Pharmaceuticals, 2021 Since the first characterization of the 5-hydroxytryptamine 2B receptor (5-HT2BR) in 1992, significant progress has been made in 5-HT2BR research. Herein, we summarize the biological function, structure, and small-molecule pharmaceutical ligands of the 5-
Qing Wang +3 more
doaj +1 more source
New England Journal of Medicine, 2003 BACKGROUND Myeloma cells may secrete factors that affect the function of osteoblasts, osteoclasts, or both. METHODS We subjected purified plasma cells from the bone marrow of patients with newly diagnosed multiple myeloma and control subjects to ...
E. Tian +6 more
semanticscholar +1 more source
Microorganisms, 2022 Infectious diseases are still a major problem worldwide. This includes microbial infections, with a constant increase in resistance to the current anti-infectives employed. Toll-like receptors (TLRs) perform a fundamental role in pathogen recognition and
Helena Merk +8 more
doaj +1 more source