Results 51 to 60 of about 1,028,152 (221)

Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO

PLoS ONE, 2014
The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response, and is increasingly recognized as an important target for therapeutic intervention in a range of diseases involving excessive oxidative stress and inflammation ...
A. Cleasby, J. Yon, P. Day, C. Richardson, I. Tickle, Pamela A. Williams, J. Callahan, R. Carr, N. Concha, J. Kerns, Hongwei Qi, T. Sweitzer, P. Ward, T. Davies   +13 more
semanticscholar   +1 more source

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice.

Journal of Clinical Investigation, 2012
Alcoholic liver disease (ALD) is characterized by steatosis and upregulation of proinflammatory cytokines, including IL-1β. IL-1β, type I IL-1 receptor (IL-1R1), and IL-1 receptor antagonist (IL-1Ra) are all important regulators of the IL-1 signaling ...
J. Petrášek, S. Bala, T. Csák, D. Lippai, K. Kodys, V. Menashy, Matthew Barrieau, S. Min, E. Kurt-Jones, G. Szabo   +9 more
semanticscholar   +1 more source

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

EMBO Journal, 2003
There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease typified by high bone mass due to the loss of SOST expression. Sclerostin,
D. Winkler, M. Sutherland, James C. Geoghegan, Changpu Yu, T. Hayes, J. Skonier, D. Shpektor, M. Jonas, Brian R. Kovacevich, K. Staehling‐Hampton, M. Appleby, M. Brunkow, J. Latham   +12 more
semanticscholar   +1 more source

Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

EMBO Journal, 1999
Oestrogens exert their physiological effects through two receptor subtypes. Here we report the three‐dimensional structure of the oestrogen receptor beta isoform (ERβ) ligand‐binding domain (LBD) in the presence of the phyto‐oestrogen genistein and the ...
A. Pike, A. Brzozowski, R. Hubbard, T. Bonn, A. Thorsell, O. Engström, J. Ljunggren, J. Gustafsson, M. Carlquist   +8 more
semanticscholar   +1 more source

Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.

Arthritis & Rheumatism, 1998
OBJECTIVE To evaluate the efficacy and safety of interleukin-1 receptor antagonist (IL-1Ra) in patients with rheumatoid arthritis (RA). METHODS Patients with active and severe RA (disease duration
B. Bresnihan, J. Álvaro-Gracia, M. Cobby, M. Doherty, Z. Domljan, P. Emery, G. Nuki, K. Pavelka, R. Rau, B. Rozman, I. Watt, B. Williams, R. Aitchison, D. McCabe, P. Musikic   +14 more
semanticscholar   +1 more source

QUANTITATIVE STUDIES OF ANTAGONISTS FOR 5‐HYDROXYTRYPTAMINE [PDF]

, 1955
J. H. Gaddum, Khan A. Hameed, D. E. Hathway, F. F. Stephens   +3 more
openalex   +1 more source

Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist

Journal of Experimental Medicine, 2004
Sclerosteosis, a skeletal disorder characterized by high bone mass due to increased osteoblast activity, is caused by loss of the SOST gene product, sclerostin.
R. van Bezooijen, B. Roelen, A. Visser, L. van der Wee‐Pals, Edwin de Wilt, M. Karperien, H. Hamersma, S. Papapoulos, P. ten Dijke, C. Löwik   +9 more
semanticscholar   +1 more source

Antagonistic AI [PDF]

arXiv
The vast majority of discourse around AI development assumes that subservient, "moral" models aligned with "human values" are universally beneficial -- in short, that good AI is sycophantic AI. We explore the shadow of the sycophantic paradigm, a design space we term antagonistic AI: AI systems that are disagreeable, rude, interrupting, confrontational,
arxiv  

Effects of Serotonin Antagonists in Normal Subjects and Patients with Carcinoid Tumors [PDF]

, 1957
Roland E. Schneckloth, Irvine H. Page, Francesco Greco, A. C. Corcoran   +3 more
openalex   +1 more source

IMMUNOLOGIC STUDIES IN INSULIN RESISTANCE. III. MEASUREMENT OF AN INSULIN ANTAGONIST IN THE SERUM OF AN INSULIN-RESISTANT PATIENT BY THE BLOOD SUGAR CURVE METHOD IN MICE [PDF]

, 1947
Francis C. Lowell
openalex   +1 more source