Results 51 to 60 of about 1,519,714 (391)

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Bianchi C, Broad RM, Buchheit KH, Budhoo MR, Carter D, Costall B, Costa M, Craig DA, D'Amato M, Eglen RM, Engel G, Erspamer V, Feldberg W, Gale JD, Gebauer A, Gershon MD, Gozlan H, Hedge SS, Hume SP, Humphrey PP, Ivancheva C, Javid FA, Kilbinger H, Kuemmerle JF, Leysen JE, Malleron JL, Mawe GM, Nowak TV, Pan H, Racke K, Radomirov R, Satoh Y, Weber LJ, Yamamoto I   +33 more
core   +1 more source

ACTH Antagonists [PDF]

Proceedings of the National Academy of Sciences, 1974
Structural modifications within the active site of the ACTH molecule have produced analogs that inhibit the hormone sensitive adenylate cyclase system of bovine adrenal cortical plasma membranes. It is demonstrated that the tryptophan residue of the ACTH molecule is essential for stimulation of the enzyme.
Klaus Hofmann, Frances M. Finn, Judith Montibeller   +2 more
openaire   +3 more sources

Short-term comparison of intraarticular administration of IL-1 receptor antagonist and platelet-rich plasma for osteoarthritis treatment

Medicine Science, 2023
Osteoarthritis (OA) is a prevalent joint condition that affects areas such as the knee, hip, hand, and spine. In treating mild to moderate cases of OA, treatment options such as intraarticular corticosteroids, viscosupplementation, glucosamine and ...
Yasin Guler, Ersin Kuyucu, Adnan Kara, Omer Serdar Hakyemez, Ferhat Say, Ahmet Murat Bulbul   +5 more
doaj   +1 more source

Predicted Structures and Dynamics for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors [PDF]

, 2011
Subtype 2 serotonin (5-hydroxytryptamine, 5-HT) receptors are major drug targets for schizophrenia, feeding disorders, perception, depression, migraines, hypertension, anxiety, hallucinogens, and gastrointestinal dysfunctions.' We report here ...
Abrol, Ravinder, Goddard, William A., III, Heo, Jiyoung, Kim, Soo-Kyung, Li, Youyong   +4 more
core   +2 more sources

Potency of Yeasts to Promote Induced Resistance on Chili Plant (Capsicum annuum L.) against Yellow Leaf Curl Disease

Jurnal Perlindungan Tanaman Indonesia, 2020
Yellow leaf curl is a major disease on chili plants. The use of antagonistic yeasts as the control agents is a good alternative in  an environmentally friendly control method.
Sri Hartati, Rika Meliansyah, Luciana Djaya, Ceppy Nasahi, Ramadhan Kamal Putra   +4 more
doaj   +1 more source

In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol

Marine Drugs, 2021
Phlorotannins are polyphenolic compounds in marine alga, especially the brown algae. Among numerous phlorotannins, dieckol and phlorofucofuroeckol-A (PFF-A) are the major ones and despite a wider biological activity profile, knowledge of the G protein ...
Pradeep Paudel, Su Hui Seong, Se Eun Park, Jong Hoon Ryu, Hyun Ah Jung, Jae Sue Choi   +5 more
doaj   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Effects of vedolizumab induction therapy for patients with Crohn's disease in whom tumor necrosis factor antagonist treatment failed.

Gastroenterology, 2014
BACKGROUND & AIMS There is an increasing need for new treatments for patients with Crohn's disease (CD) in whom previous therapy with tumor necrosis factor (TNF) antagonists has failed.
B. Sands, B. Feagan, P. Rutgeerts, J. Colombel, W. Sandborn, R. Sy, G. D'Haens, S. Ben-Horin, Jing Xu, M. Rosario, I. Fox, A. Parikh, C. Milch, S. Hanauer   +13 more
semanticscholar   +1 more source

Shedding New Light on The Role of ανβ3 and α5β1 Integrins in Rheumatoid Arthritis

Molecules, 2019
ανβ3 and α5β1 are essential glycoproteins involved in the pathogenesis of rheumatoid arthritis (RA). Understanding of the role these integrins play in disease have been analyzed via description of cells-expressing αν ...
Arwa Morshed, Abdul Baset Abbas, Jialiang Hu, Hanmei Xu   +3 more
doaj   +1 more source

Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core

Pharmaceuticals, 2021
Activation of the neuropeptide S receptor (NPSR) system has been shown to produce anxiolytic-like actions, arousal, and enhance memory consolidation, whereas blockade of the NPSR has been shown to reduce relapse to substances of abuse and duration of ...
Allison Zarkin, Rajwana Jahan, Rajendra Uprety, Yanan Zhang, Charles McElhinny, Rodney Snyder, Elaine Gay, Gabriel Jewula, Heather Bool, Stewart D Clark, Scott Runyon   +10 more
doaj   +1 more source