Results 61 to 70 of about 1,481,945 (415)
Molecules, 2022 Depression is the most common mental illness, affecting approximately 4.4% of the global population. Despite many available treatments, some patients exhibit treatment-resistant depression.
Arnold Petrus Smith +2 more
doaj +1 more source
Population and species neighbor identity impact trait–trait relationships and plant performance
Population Ecology, EarlyView.We evaluated how populations and species identity influence plant performance and trait outcomes in mixtures, and assessed trait variation among populations of two forb species native to the western United States (Dieteria canescens and Heterotheca villosa) following three interaction treatments (single‐population monoculture, two‐population mixture ...
Alicia J. Foxx +2 more
wiley +1 more source
Pharmaceutical Biology, 2018 Context: Quercetin (QCT) has been known as a potential therapeutic strategy for gastrointestinal diseases because it contributes to the stabilization of mast cells, the prevention of histamine release and modulation of CaCC chloride channel.
Ji Eun Kim +9 more
doaj +1 more source
Cells, 2020 Toll-like receptors (TLRs) play a fundamental role in the inflammatory response against invading pathogens. However, the dysregulation of TLR-signaling pathways is implicated in several autoimmune/inflammatory diseases.
Mahesh Chandra Patra +13 more
doaj +1 more source
Biological Control of Plant Pathogens: A Global Perspective
Microorganisms, 2022 The increase in the world population has generated an important need for both quality and quantity agricultural products, which has led to a significant surge in the use of chemical pesticides to fight crop diseases.
Rachid Lahlali +7 more
doaj +1 more source
Towards an efficient inverse static model of a Festo actuator made of two antagonist muscles for hybrid control of its position and stiffness [PDF]
arXiv, 2021 The Festo air muscle is today one of the most known commercial version of the so-called McKibben pneumatic artificial muscle. A major advantage of handmade McKibben muscles, as well as its commercial versions, lies in the possibility it offers of realizing antagonist muscle actuator on the model of the biceps-triceps system.
arxiv
SPA70 is a potent antagonist of human pregnane X receptor
Nature Communications, 2017 Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70
Wenwei Lin +9 more
semanticscholar +1 more source
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]
, 2018 Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua +9 more
core +2 more sources
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Proceedings of the National Academy of Sciences of the United States of America, 1986 The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that is active after oral administration and whose mechanism of action is unknown. We have detected high-affinity (Kd = 37.2 +/- 2.
E. Wong +5 more
semanticscholar +1 more source