Results 71 to 80 of about 1,519,714 (391)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Proceedings of the National Academy of Sciences of the United States of America, 1986
The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that is active after oral administration and whose mechanism of action is unknown. We have detected high-affinity (Kd = 37.2 +/- 2.
E. Wong, J. Kemp, T. Priestley, A. R. Knight, G. Woodruff, L. Iversen   +5 more
semanticscholar   +1 more source

NMDA Receptor Modulators in the Treatment of Drug Addiction

Pharmaceuticals, 2013
Glutamate plays a pivotal role in drug addiction, and the N-methyl-D-aspartate (NMDA) glutamate receptor subtype serves as a molecular target for several drugs of abuse. In this review, we will provide an overview of NMDA receptor structure and function,
M. Foster Olive, Natali E. Nemirovsky, Seven E. Tomek, Amber L. Lacrosse   +3 more
doaj   +1 more source

Effects of a Secretin Receptor Antagonist on Cerebellar Learning [PDF]

, 2016
Eyeblink conditioning (EBC) is an important procedure used to understand the neuronal plasticity that occurs with learning and memory. Delay EBC requires a brainstem-cerebellar circuit while the role of the cerebellum in trace EBC is not as well ...
Kather, Josefina M
core   +1 more source

Distribution of cells responsive to 5-HT6 receptor antagonist-induced hypophagia [PDF]

, 2014
Open Access funded by Medical Research CouncilPeer reviewedPublisher ...
Alastair S. Garfield, Blevins, Fisas, Frassetto, Garfield, Grill, Heal, Heisler, Heisler, Heisler, Hirst, Holenz, Jill Shaw, Lam, Lam, Leibowitz, Li, Lora K. Heisler, Luke K. Burke, Mark L. Evans, Michaud, Monti, Roberts, Wesołowska, Woolley, Woolley, Xu, Xu, Yeo   +28 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia.

New England Journal of Medicine, 2006
BACKGROUND Hyponatremia (serum sodium concentration,
R. Schrier, P. Gross, M. Gheorghiade, T. Berl, J. Verbalis, F. Czerwiec, C. Orlandi   +6 more
semanticscholar   +1 more source

[O-methyl-¹¹C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([¹¹C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey

Molecules, 2018
Selective high-affinity antagonists for the dopamine D3 receptor (D3R) are sought for treating substance use disorders. Positron emission tomography (PET) with an effective D3R radioligand could be a useful tool for the development of such therapeutics ...
Jeih-San Liow, Cheryl L. Morse, Shuiyu Lu, Michael Frankland, George L. Tye, Sami S. Zoghbi, Robert L. Gladding, Anver B. Shaik, Robert B. Innis, Amy H. Newman, Victor W. Pike   +10 more
doaj   +1 more source

A Novel Robust Screening Assay Identifies Pseudomonas Strains as Reliable Antagonists of the Root-Knot Nematode Meloidogyne incognita

Microorganisms, 2023
Forty-four bacterial strains isolated from greenhouse soil and beetroots were tested for their antagonistic activity against the plant-parasitic root-knot nematode (RKN) Meloidogyne incognita, which causes significant yield losses in a number of ...
Tobias Stucky, Miro Hochstrasser, Silvan Meyer, Tina Segessemann, Andrea Caroline Ruthes, Christian H. Ahrens, Cosima Pelludat, Paul Dahlin   +7 more
doaj   +1 more source

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]

, 2010
<b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Alemany, Alewijnse, Alexander, Ancellin, Blazquez, Chun, Coussin, Felder, French, Galve-Roperh, Giuliano, Grainger, Hajrasouliha, Hemmings, Hemmings, Herradon, Ho, Ho, Howlett, Igarashi, Igarashi, Ikeda, Jarai, Kobayashi, Long, Melendez, Mukhopadhyay, Mulvany, Nofer, O'Sullivan, Offertaler, Oka, Paugh, Peters, Pitson, Pratt, Pyne, Pyne, Romano, Roviezzo, Sanchez, Sarkar, Smart, Sukocheva, Taha, Venkataraman, White, Zygmunt   +47 more
core   +2 more sources