Results 81 to 90 of about 1,519,714 (391)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2019 Alaa Alachkar,1 Nadia Khan,1 Dorota Łażewska,2 Katarzyna Kieć-Kononowicz,2 Bassem Sadek1 1Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; 2Department of
Alachkar A +4 more
doaj
Potential Adiponectin Receptor Response Modifier Therapeutics
Frontiers in Endocrinology, 2019 Many human diseases may benefit from adiponectin replacement therapy, but due to pharmacological disadvantages of the intact protein, druggable options focus on peptidic, and small molecule agonists of the adiponectin receptor.
Laszlo Otvos, Laszlo Otvos, Laszlo Otvos
doaj +1 more source
Molecules, 2023 Three major subtypes of ionotropic receptors regulate glutamatergic synaptic transmission, one of which is α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors (AMPARs).
Mohammad Qneibi +3 more
doaj +1 more source
Effect of an antiandrogenic H
, 1988 Because biochemical 'feminization' of the liver in males is observed with hepatic regeneration and because the hepatic regenerative response in females is greater than that in males, the posibility that antiandrogens might potentiate liver regeneration ...
Chapchap, P +7 more
core
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Journal of the American Medical Association (JAMA), 2003 CONTEXT Despite evidence of efficacy of antihypertensive agents in treating hypertensive patients, safety and efficacy of antihypertensive agents for coronary artery disease (CAD) have been discerned only from subgroup analyses in large trials ...
C. Pepine +15 more
semanticscholar +1 more source
Journal of Crop Protection, 2021 Biocontrol agents have different growth and biocontrol responses under the influence of physicochemical parameters. The culture medium is one of these parameters. Therefore, in this study, the effects of eight liquid media were investigated on the growth
Zhila Delkhah, Keivan Behboudi
doaj
Target sites for chemical regulation of strigolactone signaling
Frontiers in Plant Science, 2014 Demands for plant growth regulators (chemicals that control plant growth) are increasing globally, especially in developing countries. Both positive and negative plant growth regulators are widely used to enhance crop production and to suppress unwanted ...
Hidemitsu eNakamura +3 more
doaj +1 more source
Marine Drugs, 2023 The dinoflagellate Prorocentrum triestinum forms high biomass blooms that discolor the water (red tides), which may pose a serious threat to marine fauna and aquaculture exploitations.
Victoria Cruz-Balladares +6 more
doaj +1 more source