Results 41 to 50 of about 7,952 (188)

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Takayasu arteritis, ocular ischemic syndrome, and neovascular glaucoma—A case report

Kerala Journal of Ophthalmology
Takayasu arteritis (TA) is an idiopathic, autoimmune rare inflammatory granulomatous large vessel vasculitis affecting males more than females. Ocular involvement occurs in up to 45% of cases due to ocular hypoperfusion.
Sujit Das, Neelima Mehrotra, Ria Batra, Ram Mohan Mishra   +3 more
doaj   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Deucravacitinib in Active Psoriatic Arthritis: Efficacy and Safety Up to 52 Weeks From the Randomized, Double‐Blind, Phase 3 POETYK PsA‐2 Trial

Arthritis &Rheumatology, EarlyView.
Objective To assess the efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with psoriatic arthritis (PsA) who were naive to biologic disease‐modifying antirheumatic drugs or received tumor necrosis factor inhibitors. Methods In the 52‐week, double‐blind, placebo‐controlled, phase 3 Program for Evaluation
Philip J. Mease, Vinod Chandran, April W. Armstrong, Ricardo Blanco, Alexis Ogdie, Evan L. Siegel, Alice B. Gottlieb, Xiaofeng Zeng, Diamant Thaçi, Mitsumasa Kishimoto, Hendrik Schulze‐Koops, Alan Kivitz, Eva Dokoupilová, Akimichi Morita, Eric M. Ruderman, Michael Plewinski, Kejia Wang, Caroline Sardinas, Eleni Vritzali, John Vaile, Atul Deodhar   +20 more
wiley   +1 more source

Evaluating discrepancies between high‐yield neuroscience conditions in preclerkship medical education and national clinical incidence

Anatomical Sciences Education, EarlyView.
Abstract Medical education must balance foundational science with clinical relevance. Increasing emphasis on standardized assessments has led to prioritization of “high‐yield” conditions—those most likely to be assessed. Subsequently, educators and students often prioritize these conditions.
Kathryn Veazey, Oheneba Boadum
wiley   +1 more source

Anterior ischemic optic neuropathy secondary to interferon alpha

Zdravniški Vestnik, 2005
Background: Anterior ischemic optic neuropathy rarely occurs with interferon alpha therapy. The mechanism by which interferon induces anterior ischemic optic neuropathy is unknown.Methods: A 62-year-old man presented with complaints of sudden severe loss
Stanka Godina-Kariž, Nives Avancini, Stojan Kariž   +2 more
doaj  

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Artificial Intelligence for Distinguishing Glaucoma From Its Mimickers: A Narrative Review of Diagnostic Pitfalls, Validation Gaps, and Clinical Translation

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) has advanced rapidly in glaucoma, but many models remain optimized for case‐control detection rather than the clinically harder task of distinguishing glaucoma from its mimickers. This narrative review primarily examined literature published from January 2018 to March 2026 on glaucoma AI, difficult comparator ...
Cansu Yüksel Elgin
wiley   +1 more source

Optic Nerve Thickness Assessed by Ocular Ultrasonography in Obstructive Sleep Apnea

Journal of Ultrasound in Medicine, EarlyView.
Objectives Obstructive sleep apnea (OSA) has been associated with various ocular complications, yet ultrasonographic evaluation of optic nerve thickness and its relationship with nocturnal hypoxemia remains poorly understood. This study aimed to evaluate optic nerve thickness and globe dimensions using ocular ultrasonography in patients with different ...
Buğra Kerget, Eyüp Çetin, Alperen Aksakal, Sırma Merve Çetin, Mustafa Buğra Coşkuner   +4 more
wiley   +1 more source

Valosin-containing protein modulator KUS121 protects retinal neurons in a rat model of anterior ischemic optic neuropathy

Scientific Reports
Ischemic optic neuropathy is a leading cause of sudden vision loss, particularly in elderly individuals, with no available effective treatments. Ischemia-induced irreversible damage to optic nerve fibers highlights the need for novel therapies with ...
Chinami Kikkawa, Hanako Ohashi Ikeda, Masayuki Hata, Sachiko Iwai, Akitaka Tsujikawa   +4 more
doaj   +1 more source