Results 41 to 50 of about 29,812 (195)

Modifcation of anthelmintic drugs by nanotechnology (review)

, 2022
The purpose of the research is to analyze and summarize the literature data and the results of our own studies on the use of drug delivery systems and methods for increasing the solubility and efcacy of anthelmintic drugs.Helminthoses are one of the most
I. A. Arkhipov, S. S. Khalikov, M. V. Arisov, A. I. Varlamova   +3 more
core   +1 more source

The Anthelmintic Activity of Nepeta racemosa Lam. Against Gastrointestinal Nematodes of Sheep: Rosmarinic Acid Quantification and In Silico Tubulin-Binding Studies

Pathogens
Gastrointestinal nematodes (GINs) inflict significant economic losses on sheep and goat farming globally due to reduced productivity and the development of anthelmintic resistance.
Büşra Karpuz Ağören, Mahmut Sinan Erez, Esma Kozan, Aydın Dağyaran, Mevlüt Akdağ, Eduardo Sobarzo-Sánchez, Esra Küpeli Akkol   +6 more
doaj   +1 more source

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

The transcriptional response of Caenorhabditis elegans to ivermectin exposure identifies novel genes involved in the response to reduced food intake [PDF]

, 2012
We have examined the transcriptional response of Caenorhabditis elegans following exposure to the anthelmintic drug ivermectin (IVM) using whole genome microarrays and real-time QPCR.
Sai P. Ravikumar, Gilleard John S., John S. Gilleard (183499), Steven T. Laing, Ravikumar, S.P., Sai P. Ravikumar (183489), Laing Roz, Al Ivens, Steven T Laing, Steven T. Laing (183480), Al Ivens (183483), Laing Steven T., Butler Victoria, Debra J. Woods (167740), Sai P Ravikumar, Ravikumar Sai P., Laing, S.T., Woods, D.J., Woods Debra J., Gilleard, J.S., Victoria Butler (183486), Butler, V., Roz Laing, Roz Laing (183493), Laing, R., John S Gilleard, John S. Gilleard, Victoria Butler, Debra J. Woods, Debra J Woods, Ivens, A., Ivens Al   +31 more
core   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Evaluation of Anthelmintic Activities of Persea americana and Musa sikkimensis [PDF]

The goal was to know about the anthelmintic properties of the leaves of P. americana and peels of M. sikkimensis. An ethanolic extract from the leaves of P. americana and aqueous extract of M. sikkimensis was used to screen for phytochemicals and analyse
Nihar Ranjan Sarmah, Preety Rani Gupta, Ananya Bhattacharjee, Raksha Sharma, Tashi Narbu Moktan   +4 more
core   +1 more source

Anthelmintic Resistance in Farm Animals [PDF]

, 2018
Anthelmintic resistance means that developing genetically transmitted lack of susceptibility to an anthelmintic which is previously known to be susceptible to a parasite population.
EREZ, Mahmut Sinan; KOZAN, Esma
core   +1 more source

Parascaris spp. induced surgical colic in juvenile horses—A Scandinavian perspective

Equine Veterinary Journal, EarlyView.
Abstract Background Parascaris spp. commonly infects foals, and high burdens can cause fatal small intestinal impactions. Progressive anthelmintic resistance poses a risk for an increase of Parascaris spp. related disease in juvenile horses. Objectives To investigate Parascaris‐related surgical intestinal lesions, with special emphasis on ascarid ...
E. Tydén, I. R. Hellings, K. Toft Nielsen, A. Bergren, I. Holmgren, S. Attin, T. Pihl, A. Kendall, Y. Hedberg Alm   +8 more
wiley   +1 more source

Preprint: Screening the Medicines for Malaria Pandemic Response Box chemical library on Caenorhabditis elegans identifies re-profiled candidate anthelmintic drug leads

, 2022
The 3 major classes of soil transmitted helminths (whipworm, hookworm and Ascaris) affect 1.5 billion people worldwide mostly in poor countries, where they have adverse effects on child development, nutrition, and the work capacity of adults.
Else, K.J., Bataille, C.J.R., Forman, R., Nick, M., Partridge, F.A., Sattelle, D.B., Russell, A.J.   +6 more
core   +1 more source