Results 31 to 40 of about 8,901 (206)

RESISTANCE TO ANTHELMINTICS

Trakia Journal of Sciences
In pasture-raised animals, parasitic infections result in significant financial losses. On the other hand, their prevention and limitation require significant financial resources.
V. Radev
doaj   +1 more source

Comparison of the in vitro anthelmintic effects of Acacia nilotica and Acacia raddiana

Parasite, 2017
Gastrointestinal nematodes are a major threat to small ruminant rearing in the Sahel area, where farmers traditionally use bioactive plants to control these worms, including Acacia nilotica and Acacia raddiana.
Zabré Geneviève, Kaboré Adama, Bayala Balé, Katiki Luciana M., Costa-Júnior Lívio Martins, Tamboura Hamidou H., Belem Adrien M.G., Abdalla Adibe L., Niderkorn Vincent, Hoste Hervé, Louvandini Helder   +10 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Parascaris spp. induced surgical colic in juvenile horses—A Scandinavian perspective

Equine Veterinary Journal, EarlyView.
Abstract Background Parascaris spp. commonly infects foals, and high burdens can cause fatal small intestinal impactions. Progressive anthelmintic resistance poses a risk for an increase of Parascaris spp. related disease in juvenile horses. Objectives To investigate Parascaris‐related surgical intestinal lesions, with special emphasis on ascarid ...
E. Tydén, I. R. Hellings, K. Toft Nielsen, A. Bergren, I. Holmgren, S. Attin, T. Pihl, A. Kendall, Y. Hedberg Alm   +8 more
wiley   +1 more source

The ATP bioluminescence assay: a new application and optimization for viability testing in the parasitic nematode Haemonchus contortus

Veterinary Research, 2021
The parasitic gastrointestinal nematode Haemonchus contortus causes serious economic losses to agriculture due to infection and disease in small ruminant livestock.
Linh Thuy Nguyen, Markéta Zajíčková, Eva Mašátová, Petra Matoušková, Lenka Skálová   +4 more
doaj   +1 more source

Corticosterone Under Experimental Manipulation of Nutrition and Parasite Burden in a Wild Rodent System

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Environmental pressures shape survival and life‐history dynamics partly by triggering the release of glucocorticoids, whose short‐term benefits but long‐term costs make it essential to understand what drives their levels. Here, we used an experimental manipulation of two environmental stressors—food availability and parasite burden—to directly
Sarah E. Wolf, Olga Dłużniewska, Simon A. Babayan, Amy B. Pedersen, Tom J. Little   +4 more
wiley   +1 more source

Healthier Herds, Heavier Workloads? The Gendered Time and Resource Implications of Herd Health Management in Kenyan Dairy Systems

Journal of International Development, EarlyView.
ABSTRACT Strategies for sustainable intensification of livestock are critical for food system transformation. In dairying systems, herd health management is among such strategies. Although adoption patterns and productivity gains have been analysed in previous studies, the social implications are still not well understood.
Kevin W. Maina, Martin C. Parlasca, Elizaphan J. O. Rao   +2 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Conservation status of species used in the UK herbal medicine industry

PLANTS, PEOPLE, PLANET, EarlyView.
Given the ongoing biodiversity crisis, sustainable use and management of medicinal plants is critical. We assessed the conservation status, threats and conservation actions of 298 species sold by UK suppliers to medical herbalists. We found that most species used are unevaluated, representing a gap in conservation knowledge, and of those with ...
Isabella Flowers, Jon C. Lovett, Christopher Hassall   +2 more
wiley   +1 more source