Results 41 to 50 of about 41,721 (252)

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

bioRxiv, 2018
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations.
K. Miner, K. Labitzke, Benxian Liu, Paul Wang, Kathryn Henckels, Kevin Gaida, R. Elliott, J. Chen, Longbin Liu, A. Leith, E. Trueblood, Kelly Hensley, X. Xia, O. Homann, B. Bennett, M. Fiorino, J. Whoriskey, Gang Yu, S. Escobar, Min Wong, T. Born, A. Budelsky, M. Comeau, Dirk E. Smith, J. Phillips, J. Johnston, J. McGivern, Kerstin Weikl, D. Powers, K. Kunzelmann, Deanna Mohn, A. Hochheimer, J. Sullivan   +32 more
semanticscholar   +1 more source

Evaluation of Orally Administered Anthelmintic Treatment Options for Dentostomella translucida in Naturally Infected Mongolian Gerbils (Meriones unguiculatus)

Türkiye Parazitoloji Dergisi, 2021
Objective:This study aimed to evaluate the efficacy of eprinomectin, moxidectin and fenbendazole for treating Dentostomella translucida infections in naturally infected Mongolian gerbils (Meriones unguiculatus).Methods:A total of 28 gerbils were placed ...
Süleyman Aypak, Cavit Kum, Metin Pekağırbaş, Adnan Ayan, Tülin Karagenç   +4 more
doaj   +1 more source

Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics

Scientific Reports, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
R. Tyagi, M. Elfawal, S. Wildman, Jonathan D. M. Helander, Christina A. Bulman, J. Sakanari, B. Rosa, P. Brindley, J. Janetka, R. Aroian, M. Mitreva   +10 more
semanticscholar   +1 more source

A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity

Pharmaceuticals, 2022
Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including Haemonchus contortus, are particularly important.
Harrison T. Shanley, Aya C. Taki, Joseph J. Byrne, Abdul Jabbar, Tim N. C. Wells, Kirandeep Samby, Peter R. Boag, Nghi Nguyen, Brad E. Sleebs, Robin B. Gasser   +9 more
doaj   +1 more source

Resistance to chemotherapy: What are the risks for the reindeer industry?

Rangifer, 1990
Although no drug resistance has been reported so far for parasites of reindeer, it would be unwise to assume that this situation will remain the same indefinitely.
P. J. Waller
doaj   +1 more source

Simultaneous Determination of Multiple Contaminants in Chicken Liver Using Dispersive Liquid-Liquid Microextraction (DLLME) Detected by LC-HRMS/MS

Foods, 2023
Simultaneous determination of a mixture of food contaminants, including pesticides, sulphonamides, fluoroquinolones, anthelmintics, and aflatoxin B1, in solid biological samples (chicken liver) by dispersive liquid-liquid microextraction/liquid ...
Belete Eshetu Gebreyohannes, Simiso Dube, Mathew Muzi Nindi   +2 more
doaj   +1 more source

Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics.

ACS Infectious Diseases, 2018
The enormous prevalence of infections caused by parasitic nematodes worldwide, coupled to the rapid emergence of their resistance to commonly used anthelmintic drugs, presents an urgent need for the discovery of new drugs.
R. Tyagi, A. R. Maddirala, M. Elfawal, Chelsea Fischer, Christina A. Bulman, B. Rosa, Xin Gao, Ryan Chugani, Mingzhou Zhou, Jonathan D. M. Helander, P. Brindley, C. Tseng, I. Greig, J. Sakanari, S. Wildman, R. Aroian, J. Janetka, M. Mitreva   +17 more
semanticscholar   +1 more source

Field evaluation of the efficacy of common anthelmintics used in the control of gastrointestinal nematodes of sheep in Dabat district, Northwest Ethiopia

Irish Veterinary Journal, 2017
BackgroundGastrointestinal nematode (GIN) infections are the main impediments that restrict the welfare and productivity of small ruminant in the world.
Z. Seyoum, Yitayew Demessie, Basazinew Bogale, A. Melaku   +3 more
semanticscholar   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Reprofiled anthelmintics abate hypervirulent stationary-phase Clostridium difficile

Scientific Reports, 2016
Prolonged use of broad-spectrum antibiotics disrupts the indigenous gut microbiota, which consequently enables toxigenic Clostridium difficile species to proliferate and cause infection. The burden of C.
Major Gooyit, K. Janda
semanticscholar   +1 more source