Results 241 to 250 of about 19,635 (271)
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2004
Bacillus anthracis, the etiological agent of anthrax, secretes three polypeptides that assemble into toxic complexes on the cell surfaces of the host it infects. One of these polypeptides, protective antigen (PA), binds to the integrin-like domains of ubiquitously expressed membrane proteins of mammalian cells.
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Bacillus anthracis, the etiological agent of anthrax, secretes three polypeptides that assemble into toxic complexes on the cell surfaces of the host it infects. One of these polypeptides, protective antigen (PA), binds to the integrin-like domains of ubiquitously expressed membrane proteins of mammalian cells.
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Structure and Function of Anthrax Toxin
2002Anthrax toxin is a binary A-B toxin comprised of protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF). In the presence of a host cell-surface receptor, PA can mediate the delivery of EF and LF from the extracellular milieu into the host cell cytosol to effect toxicity.
D.B. Lacy, Robert J. Collier
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Fighting Anthrax with a Mutant Toxin
Science, 2001There is an urgent need to develop new therapeutics against the microbe causing anthrax, which has the potential to be used in biological warfare. In their Perspective, Olsnes and Wesche discuss a new therapeutic approach designed by Sellman and colleagues.
Sjur Olsnes, Jørgen Wesche
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Designing a polyvalent inhibitor of anthrax toxin
Nature Biotechnology, 2001Screening peptide libraries is a proven strategy for identifying inhibitors of protein-ligand interactions. Compounds identified in these screens often bind to their targets with low affinities. When the target protein is present at a high density on the surface of cells or other biological surfaces, it is sometimes possible to increase the biological ...
R. John Collier +7 more
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Evidence for adjuvanticity of anthrax edema toxin
Vaccine, 2006Bacillus anthracis edema factor (EF) is an adenylate cyclase that increases intracellular cAMP concentrations. Since EF is present as a contaminant in the licensed protective antigen(PA)-based vaccines, we investigated its effect on anti-PA humoral immune response in BALB/c mice.
Jean-Nicolas Tournier +3 more
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Identification of the cellular receptor for anthrax toxin
Nature, 2001The tripartite toxin secreted by Bacillus anthracis, the causative agent of anthrax, helps the bacterium evade the immune system and can kill the host during a systemic infection. Two components of the toxin enzymatically modify substrates within the cytosol of mammalian cells: oedema factor (OF) is an adenylate cyclase that impairs host defences ...
Michael Mourez +5 more
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[16] Production and purification of anthrax toxin
1988Publisher Summary This chapter describes the production and purification of anthrax toxin. Bacillus anthracis secretes three proteins that are collectively known as anthrax toxin. The protective antigen (PA, 85 kDa), lethal factor (LF, 83 kDa), and edema factor (EF, 89 kDa) proteins individually have no known toxic activities.
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Anthrax Toxin: Primary Site of Action
Journal of Infectious Diseases, 1968Abstract : Administration of anthrax toxin via the cerebrospinal fluid demonstrates positively that the toxin alters the body's physiology, primarily via the central nervous system, and kills by terminal anoxia mediated by the central nervous system.
Ralph E. Lincoln +5 more
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Three steps to targeting anthrax toxin
Trends in Molecular Medicine, 2002Anthrax toxin is responsible for the severe symptoms and death associated with inhalational anthrax (Fig. 1Fig. 1). Inhaled Bacillus anthracis spores are phagocytosed by macrophages, transported to the lymph nodes where germination occurs up to 60days later, and the new vegetative bacteria produce the toxin.
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Environmental drivers of biseasonal anthrax outbreak dynamics in two multihost savanna systems
Ecological Monographs, 2022Sunday O Ochai +2 more
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