Anti-Amoebic Properties of Carbonyl Thiourea Derivatives [PDF]
Molecules, 2014 Thiourea derivatives display a broad spectrum of applications in chemistry, various industries, medicines and various other fields. Recently, different thiourea derivatives have been synthesized and explored for their anti-microbial properties. In this study, four carbonyl thiourea derivatives were synthesized and characterized, and then further ...
Ibrahim MA, Yusof MS, Amin NM.
exaly +6 more sources
The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii. [PDF]
Microorganisms, 2022 Acanthamoeba is a free-living protozoan known to cause keratitis most commonly, especially among contact lens wearers. Treatment of Acanthamoeba keratitis is challenging as Acanthamoeba can encyst from the active form, a trophozoite, into a hibernating cyst that is refractory to antibiotics and difficult to kill; therefore, there is a need for more ...
Peguda HK +5 more
europepmc +5 more sources
Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes. [PDF]
Front Microbiol, 2023 Acanthamoeba species, Naegleria fowleri, and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are commonly misdiagnosed and have sub-optimal treatment regimens which contribute to the extremely high mortality rates ...
Ferrins L +30 more
europepmc +5 more sources
Antineoplastic kinase inhibitors: A new class of potent anti-amoebic compounds. [PDF]
PLoS Negl Trop Dis, 2021 Entamoeba histolytica is a protozoan parasite which infects approximately 50 million people worldwide, resulting in an estimated 70,000 deaths every year. Since the 1960s E .
Sauvey C +4 more
europepmc +7 more sources
Riluzole, a Derivative of Benzothiazole as a Potential Anti-Amoebic Agent against Entamoeba histolytica. [PDF]
Pharmaceuticals (Basel), 2023 Amoebiasis is produced by the parasite Entamoeba histolytica; this disease affects millions of people throughout the world who may suffer from amoebic colitis or amoebic liver abscess. Metronidazole is used to treat this protozoan, but it causes important adverse effects that limit its use.
Velásquez-Torres M +9 more
europepmc +4 more sources
High-throughput phenotypic screen identifies a new family of potent anti-amoebic compounds. [PDF]
PLoS One, 2023 Entamoeba histolytica is a disease-causing parasitic amoeba which affects an estimated 50 million people worldwide, particularly in socioeconomically vulnerable populations experiencing water sanitation issues. Infection with E . histolytica
Sauvey C +5 more
europepmc +5 more sources
The Effect of Anti-Amoebic Agents and Ce6-PDT on Acanthamoeba castellanii Trophozoites and Cysts, In Vitro. [PDF]
Transl Vis Sci Technol, 2020 The purpose of this study was to analyze the concentration-dependent effects of biguanides (polyhexamethylene biguanide [PHMB], chlorhexidine [CH]); diamidines (hexamidine-diisethionate [HD], propamidine-isethionate [PD], dibromopropamidine-diisethionate [DD]); natamycin (NM); miltefosine (MF); povidone iodine (PVPI), and chlorin e6 PDT on Acanthamoeba
Shi L +10 more
europepmc +3 more sources
Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii. [PDF]
HeliyonA rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba. Currently, no therapeutic agent can completely eradicate or prevent GAE.
Alishba +7 more
europepmc +5 more sources
Anti-amoebic and biocompatible properties of nephrite-embedded contact lenses. [PDF]
Sci RepPark JH +8 more
europepmc +2 more sources
Anti-amoebic potential of azole scaffolds and nanoparticles against pathogenic Acanthamoeba [PDF]
Acta Tropica, 2020 Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. The advances in drug discovery and modifications in the chemotherapeutic agents have shown little improvement in morbidity and mortality rates associated ...
Shweta, Walvekar +6 more
openaire +2 more sources