Results 21 to 30 of about 2,076,196 (185)

Bioassay-guided fractionation of extracts from Codiaeum variegatum against Entamoeba histolytica discovers compounds that modify expression of ceramide biosynthesis related genes. [PDF]

PLoS Neglected Tropical Diseases, 2014
Leaves of Codiaeum variegatum ("garden croton") are used against bloody diarrhoea by local populations in Cameroon. This study aims to search for the active components from C.
Emmanuel Mfotie Njoya, Christian Weber, Nora Adriana Hernandez-Cuevas, Chung-Chau Hon, Yves Janin, Melanie F G Kamini, Paul F Moundipa, Nancy Guillén   +7 more
doaj   +1 more source

Antimicrobial activity of some isatin-3--thiosemicarbazone complexes [PDF]

Journal of the Serbian Chemical Society, 2008
Isatin-3-thiosemicarbazone complexes with Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and Pd(II) were synthesized and evaluated for their antimicrobial activity against 7 pathogenic bacteria and 4 fungi. The complexes have an enhanced activity compared to the
SANDRA S. KONSTANTINOVIC, BLAGA C. RADOVANOVIC, SOFIJA P. SOVILJ, SVETLANA STANOJEVIC   +3 more
doaj   +3 more sources

Repurposing CNS drugs Zonisamide and Perampanel conjugated with silver nanoparticles as an anti-amoebic agent in combating Granulomatous Amebic Encephalitis (GAE) and Primary Amebic Meningoencephalitis (PAM) infection caused by <i>Acanthamoeba castellanii</i> and <i>Naegleria Fowleri</i>. [PDF]

Parasite Epidemiol Control
Acanthamoeba castellanii (A. castellanii) and Naegleria fowleri (N. fowleri) are free-living amoebae that cause Granulomatous Amoebic Encephalitis (GAE) and Primary Amoebic Meningoencephalitis (PAM), respectively rare but often fatal central nervous ...
Apparasamy D, Kumar NK, Jones CI, Htet YM, Thevanayagam H, Ahmed U, Shaik MF, Anwar A, Rajendran K.   +8 more
europepmc   +2 more sources

Imidazothiazole Derivatives Exhibited Potent Effects against Brain-Eating Amoebae

Antibiotics, 2022
Naegleria fowleri (N. fowleri) is a free-living, unicellular, opportunistic protist responsible for the fatal central nervous system infection, primary amoebic meningoencephalitis (PAM).
Ruqaiyyah Siddiqui, Mohammed I. El-Gamal, Anania Boghossian, Balsam Qubais Saeed, Chang-Hyun Oh, Mohammed S. Abdel-Maksoud, Ahmad M. Alharbi, Hasan Alfahemi, Naveed Ahmed Khan   +8 more
doaj   +1 more source

Antiamoebic Properties of Metabolites against Naegleria fowleri and Balamuthia mandrillaris

Antibiotics, 2022
Naegleria fowleri and Balamuthia mandrillaris are free-living, opportunistic protists, distributed widely in the environment. They are responsible for primary amoebic meningoencephalitis (PAM) and granulomatous amoebic encephalitis (GAE), the fatal ...
Ruqaiyyah Siddiqui, Anania Boghossian, Bushra Khatoon, Muhammad Kawish, Ahmad M. Alharbi, Muhammad Raza Shah, Hasan Alfahemi, Naveed Ahmed Khan   +7 more
doaj   +1 more source

Nanocarrier Drug Conjugates Exhibit Potent Anti-Naegleria fowleri and Anti-Balamuthia mandrillaris Properties

Diseases, 2023
Given the opportunity and access, pathogenic protists (Balamuthia mandrillaris and Naegleria fowleri) can produce fatal infections involving the central nervous system.
Ruqaiyyah Siddiqui, Anania Boghossian, Muhammad Kawish, Tooba Jabri, Muhammad Raza Shah, Tengku Shahrul Anuar, Zainab Al-Shareef, Naveed Ahmed Khan   +7 more
doaj   +1 more source

Silver Nanoparticles Conjugated with Contact Lens Solutions May Reduce the Risk of Acanthamoeba Keratitis

Pathogens, 2021
Acanthamoeba keratitis (AK), a severe sight-threatening corneal infection, has become a significant medical problem, especially among contact lens wearers.
Edyta B. Hendiger, Marcin Padzik, Inés Sifaoui, María Reyes-Batlle, Atteneri López-Arencibia, Diana Zyskowska, Marta Grodzik, Anna Pietruczuk-Padzik, Jacek Hendiger, Gabriela Olędzka, Lidia Chomicz, José E. Piñero, Jacob Lorenzo-Morales   +12 more
doaj   +1 more source

Selected Gut Bacteria from Water Monitor Lizard Exhibit Effects against Pathogenic Acanthamoeba castellanii Belonging to the T4 Genotype

Microorganisms, 2023
Water monitor lizards (WMLs) reside in unhygienic and challenging ecological surroundings and are routinely exposed to various pathogenic microorganisms. It is possible that their gut microbiota produces substances to counter microbial infections.
Noor Akbar, Naveed Ahmed Khan, Alexander D. Giddey, Nelson C. Soares, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui   +6 more
doaj   +1 more source

High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis

American Journal of Ophthalmology Case Reports, 2019
Purpose: To describe the outcome of adjuvant high fluence photoactivated chromophore for infectious keratitis cross-linking (PACK-CXL) used to treat an advanced form of refractory Acanthamoeba keratitis (AK) diagnosed several months after initial ...
Mehrdad Nateghi Pettersson, Neil Lagali, Jes Mortensen, Victor Jofré, Per Fagerholm   +4 more
doaj   +1 more source

Benzophenone Derivatives as a New Class of Anti-Infectives Against Acanthamoeba spp. [PDF]

Arch Pharm (Weinheim)
Analogues of the human oxidosqualene cyclase inhibitor Ro 48‐8071 were designed, synthesized, and tested against Acanthamoeba hatchetti, one of the pathogens causing Acanthamoeba keratitis. The N‐propargyl derivative 4f showed strong amoebicidal activity with complete eradication of trophozoites and cysts, while exhibiting low toxicity toward human ...
Rimkus T, Geisler H, El-Jourani TB, Moumbock AFA, Schiedel M, Reichl S.   +5 more
europepmc   +2 more sources