The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii [PDF]
Microorganisms, 2022 Acanthamoeba is a free-living protozoan known to cause keratitis most commonly, especially among contact lens wearers. Treatment of Acanthamoeba keratitis is challenging as Acanthamoeba can encyst from the active form, a trophozoite, into a hibernating ...
Hari Kumar Peguda +5 more
doaj +5 more sources
Ginsenosides Rb3 and Rc Exhibit Anti-Amoebic Activities Against Naegleria fowleri, the Etiological Agent of Primary Amoebic Meningoencephalitis [PDF]
PharmaceuticalsBackground/Objectives: Naegleria fowleri is an opportunistic pathogen causing primary amoebic meningoencephalitis (PAM), a fatal neuroinflammatory disease with a high mortality rate of over 97%, in humans.
Thu Hằng Nguyễn +4 more
doaj +3 more sources
Saudi Pharmaceutical Journal, 2023 Amoebae of the genus Acanthamoeba can cause diseases such as amoebic keratitis and granulomatous amoebic encephalitis. Until now, treatment options for these diseases have not been fully effective and have several drawbacks.
Khairunisa Mohd Zamli +6 more
doaj +5 more sources
Mannich-Type Condensation and Domino Quinazolinone-Amidine Rearrangement Affords Ring-Fused Mackinazolinones with Anti-Amoebic Activity. [PDF]
Adv Synth Catal, 2023 AbstractA three‐step synthesis of anti‐amoebic, ring‐fused mackinazolinones has been developed. A Mannich‐type reaction between quinazolin‐4‐ones and N‐Cbz propanal in the presence of AgOTf afforded quinazolinones (19–94% isolated yield) bearing a newly formed heterocycle with an alkylamine appendage that, upon N‐Cbz deprotection and basification ...
Lish MS +5 more
europepmc +3 more sources
Anti-amoebic activity of acyclic and cyclic-samarium complexes on Acanthamoeba [PDF]
Parasitology Research, 2018 This work investigated the anti-amoebic activity of two samarium (Sm) complexes, the acyclic complex [bis(picrato)(pentaethylene glycol)samarium(III)] picrate-referred to as [Sm(Pic)2(EO5)](Pic)-and the cyclic complex [bis(picrato)(18-crown-6)samarium(III)] picrate-referred to as [Sm(Pic)2(18C6)](Pic).
Cindy Gunawan +2 more
exaly +3 more sources
The anti-amoebic activity of Pinus densiflora leaf extract against the brain-eating amoeba Naegleria fowleri. [PDF]
Parasites Hosts Dis<i>Naegleria fowleri</i> invades the brain and causes a fatal primary amoebic meningoencephalitis (PAM). Despite its high mortality rate of approximately 97%, an effective therapeutic drug for PAM has not been developed. Approaches with miltefosine, amphotericin B, and other antimicrobials have been clinically attempted to treat PAM, but ...
Lê HG +6 more
europepmc +3 more sources
Repurposing CNS drugs Zonisamide and Perampanel conjugated with silver nanoparticles as an anti-amoebic agent in combating Granulomatous Amebic Encephalitis (GAE) and Primary Amebic Meningoencephalitis (PAM) infection caused by Acanthamoeba castellanii and Naegleria Fowleri [PDF]
Parasite Epidemiology and ControlAcanthamoeba castellanii (A. castellanii) and Naegleria fowleri (N. fowleri) are free-living amoebae that cause Granulomatous Amoebic Encephalitis (GAE) and Primary Amoebic Meningoencephalitis (PAM), respectively rare but often fatal central nervous ...
Devandran Apparasamy +8 more
doaj +2 more sources
Anti-amoebic and biocompatible properties of nephrite-embedded contact lenses [PDF]
Scientific ReportsAcanthamoeba keratitis remains a severe complication of contact lens (CL) wear, and preventing trophozoite adhesion to the lens surface is a critical step in preventing infection.
Ji Ho Park +8 more
doaj +2 more sources
ANTI-MICROBIAL AND ANTI-AMOEBIC ACTIVITY SOME AZOMETHINES - POTENTIAL TEXTILE DYESTUFFS [PDF]
Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2016 In this paper, new synthesized three azomethine derivatives applied in dyeing textiles checking the anti-microbial properties of active components, at the same time [1-3].
DJORDJEVIC Dragan +4 more
doaj +1 more source
Evaluation of Anti-amoebic Activity of Peganum harmala Ethanolic Extract on Acanthamoeba In vitro [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2018 Background: Acanthamoeba is an opportunistic protozoan pathogen that is known to infect the cornea to produce eye keratitis and the central nervous system to produce lethal granulomatous encephalitis. The overall aim of the present study was to determine
Tooran Nayeri Chegeni +3 more
doaj +1 more source