Results 31 to 40 of about 2,808 (150)

The Activity of Polyhomoarginine against Acanthamoeba castellanii

Biology, 2022
Arginine-rich peptides can have broad-spectrum anti-bacterial and anti-fungal activities. Polyhomoarginine consists of highly cationic residues which can act on the negatively charged microbial cell membranes.
Hari Kumar Peguda, Rajamani Lakshminarayanan, Nicole A. Carnt, Zi Gu, Mark D. P. Willcox   +4 more
doaj   +1 more source

Curcumin Attenuates the Pathogenicity of Entamoeba histolytica by Regulating the Expression of Virulence Factors in an Ex-Vivo Model Infection

Pathogens, 2019
Infection with the enteric protozoan Entamoeba histolytica is still a serious public health problem, especially in developing countries. Amoebic liver abscess (ALA) is the most common extraintestinal manifestation of the amoebiasis, and it can lead to ...
Itzia Azucena Rangel-Castañeda, Pilar Carranza-Rosales, Nancy Elena Guzmán-Delgado, José Manuel Hernández-Hernández, Sirenia González-Pozos, Armando Pérez-Rangel, Araceli Castillo-Romero   +6 more
doaj   +1 more source

Antiamoebic Properties of Ceftriaxone and Zinc-Oxide–Cyclodextrin-Conjugated Ceftriaxone

Antibiotics, 2022
Acanthamoeba castellanii is a ubiquitous free-living amoeba capable of instigating keratitis and granulomatous amoebic encephalitis in humans. Treatment remains limited and inconsistent.
Zinb Makhlouf, Noor Akbar, Naveed Ahmed Khan, Muhammad Raza Shah, Ahmad M. Alharbi, Hasan Alfahemi, Ruqaiyyah Siddiqui   +6 more
doaj   +1 more source

A Fluorometric Assay for the In Vitro Evaluation of Activity against Naegleria fowleri Cysts

Microbiology Spectrum, 2022
Primary amoebic meningoencephalitis (PAM) is a lethal and rapid infection that affects the central nervous system and is caused by the free-living amoeba Naegleria fowleri.
Iñigo Arberas-Jiménez, Aitor Rizo-Liendo, Ines Sifaoui, Javier Chao-Pellicer, José E. Piñero, Jacob Lorenzo-Morales   +5 more
doaj   +1 more source

Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.

PLoS Neglected Tropical Diseases, 2020
Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia ...
Christopher A Rice, Beatrice L Colon, Emily Chen, Mitchell V Hull, Dennis E Kyle   +4 more
doaj   +1 more source

Melatonin reduces the severity of experimental amoebiasis

Parasites & Vectors, 2011
Background Melatonin has immunomodulatory effects but very little is known about its influence in protozoan infections, such as Entamoeba histolytica, which causes amoebiasis, a disease with significant morbidity and mortality.
Honório-França Adenilda C, Franca Eduardo L, Oliveira Fabrício MS, França Juliana L, França-Botelho Aline C, Caliari Marcelo V, Gomes Maria A   +6 more
doaj   +1 more source

Anti-Acanthamoeba castellanii activity of alkaloid-enriched extracts and lycorine from the Amaryllidaceae species

Brazilian Journal of Pharmaceutical Sciences, 2022
Free-living amoebae of the genus Acanthamoeba are the causative agents of granulomatous encephalitis and keratitis, severe human infections. Bioactive compounds from plants are recognized as an alternative source for the development of new drugs.
Maressa Dietrich Rosa, Jean Paulo de Andrade, Adriana Oliveira Costa, Raphael Conti, Jaume Bastida, Warley de Souza Borges, Cinthia Furst   +6 more
doaj   +1 more source

Brain-Eating Amoeba Meets Plant Defense: In Vitro and In Silico Evaluation of Malabaricones as Potent Anti-Naegleria fowleri Agents

Progress in Microbes and Molecular Biology
Naegleria fowleri (N. fowleri) is a thermophilic, free-living amoeba that causes primary amoebic meningoencephalitis (PAM), a rapidly fatal brain infection with a mortality rate exceeding 97%.
Kavitha Rajendran, Lemmuel Tayo, Marineil Gomez, Devandran Apparasamy, Haema Thevanayagam, Shealtiel William Chan, Ryan Christian Mailem, Regine Menente, Catherine Joyce Rueda, Yasodha Sivasothy, Muhamad Aqmal Othman, Usman Ahmed, Niwasini Krishna Kumar, Chris Izaak Jones, Ayaz Anwar   +14 more
doaj   +1 more source

Acanthamoeba and bacteria produce antimicrobials to target their counterpart

Parasites & Vectors, 2014
Background In the microbial ecosystem, microbes compete for space and nutrients. Consequently, some have developed the ability to kill or inhibit the growth of other competing microbes by producing antimicrobial substances.
Junaid Iqbal, Ruqaiyyah Siddiqui, Naveed Ahmed Khan   +2 more
doaj   +1 more source

Comparison of anti amoebic activity of stereoisomeric diamino and monoamino pregnene alkaloids and their N-methylated analogs

Journal of Chemical Sciences, 2013
The steroidal alkaloid 3β, 20α-diamino-pregn-5-ene (kurchamine) obtained from the stem bark of Holarrhena antidysenterica is reported to have appreciable amoebicidal activity. Its three stereoisomers namely 3α, 20β-diamino-pregn-5-ene, 3β, 20β-diamino-pregn-5-ene and 3α,20α-diamino-pregn-5-ene and their intermediate stereoisomeric monoamino pregnene ...
RAJ M VAID, K K BHUTANI
openaire   +2 more sources