Results 111 to 120 of about 70,774 (157)
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Animal models sensitive to anti‐anxiety agents
Acta Psychiatrica Scandinavica, 1998Animal models of anxiety serve two primary purposes in psycho‐pharmacological research. (i) The pharmacological profile observed in the model provides a basis which, depending on its predictive validity, permits an estimation of clinical activity. (ii) Insofar as the ‘anxiety’ occurring in the animal model is homologous to human anxiety disorders, it ...
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Anti-anxiety agents: duration of use and characteristics of users in the U.S.A.
Current Medical Research and Opinion, 1984A national survey of psychotherapeutic drug use was carried out in the U.S.A. in 1979. Data were obtained from a probability sample (n = 3161) of adults in the general population, using a clinically-oriented interview lasting an average of 90 minutes.
G D Mellinger, E H Uhlenhuth, M B Balter
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Chapter 1. Antipsychotic and Anti-anxiety Agents
Annual Reports in Medicinal Chemistry, 1966Publisher Summary This chapter discusses various antipsychotic and anti-anxiety agents. Most of the compounds discussed in the chapter are tested by two general methods: (1) the study of animal behavior following drug treatment in experimental models designed to mimic a clinical situation (conflict, avoidance, etc.) and (2) the measurement of ...
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Enhancement of 3H-diazepam binding by SQ 65,396: A novel anti-anxiety agent
Pharmacology Biochemistry and Behavior, 1978SQ 65,396, a clinically active anti-anxiety agent, enhanced the binding of 3H-diazepam at 1.5 nM. This effect was due to an increase in the affinity for the ligand, without a change in the number of 3H-diazepam binding sites. This action of SQ 65,396 may mediate its anti-anxiety effects by affecting the action of an endogenous modulator of the ...
Bernard Beer +2 more
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A Survey of Anti-Anxiety Agents Used Over the Past 30 Years
Psychosomatics, 1970exaly +3 more sources
A simple and reliable conflict procedure for testing anti-anxiety agents
Psychopharmacologia, 1971The effects of three benzodiazepines (chlordiazepoxide, diazepam, and oxazepam), meprobamate, pentobarbital, d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide were studied with a simple conflict procedure in which thirsty naive rats were periodically administered shocks for licking water.
J R, Vogel, B, Beer, D E, Clody
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The road to tranquility: The search for selective anti‐anxiety agents
Synapse, 1995AbstractThe earliest treatments of anxiety included cathartics and emetics, which were used to remove the excess of black bile (hence our word melancholia) thought to be responsible for the patient's demeanor. By the 1700s, physicians were prescribing drugs that are more selective for the CNS, chiefly opium and strengthening tonics.
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