Results 151 to 160 of about 212,146 (193)
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Animal models sensitive to anti‐anxiety agents
Acta Psychiatrica Scandinavica, 1998Animal models of anxiety serve two primary purposes in psycho‐pharmacological research. (i) The pharmacological profile observed in the model provides a basis which, depending on its predictive validity, permits an estimation of clinical activity. (ii) Insofar as the ‘anxiety’ occurring in the animal model is homologous to human anxiety disorders, it ...
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Chapter 1. Antipsychotic and Anti-anxiety Agents
1969Publisher Summary This chapter discusses results of studies focusing on antipsychotic and antianxiety agents. Studies revealed that medazepam alleviates anxiety and tension in children and adults with minimal sedative side effect and without impairment of working capacity or normal alertness.
Irwin J. Pachter, Alan A. Rubin
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Anti-anxiety agents: a pharmacoepidemiological review
Human Psychopharmacology: Clinical and Experimental, 1999The purpose of this review is to broaden the base for informed policy and to identify research issues to improve the utility of anti-anxiety agents. Data quality is discussed and the prevalence of morbid anxiety and the exposure to treatment with, and abuse of, anti-anxiety agents in different populations is presented.
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Chapter I. Antipsychotic and Anti-anxiety Agents
1968Publisher Summary This chapter elaborates on antipsychotic and antianxiety agents. The reported contribution of pyrrole nuclei to the sedative action of ketone derivatives encouraged the synthesis of relatives of ketone derivatives in which the benzene ring was replaced by pyrrole.
Irwin J. Pachter, Alan A. Rubin
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Chapter 3 Anti-Anxiety Agents, Anticonvulsants, and Sedative-Hypnotics
1979Publisher Summary This chapter summarizes the nature of the benzodiazepine receptor that has been characterized further, by the demonstration that a single class of binding sites exists in rat brain for a structurally diverse series of benzodiazepines.
Joel G. Berger, Louis C. Iorio
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Sedatives and anti-anxiety agents in critical illness
2016Abstract Sedative and anti-anxiety agents are administered to many mechanically-ventilated intensive care unit (ICU) patients. While commonly considered supportive care, suboptimal administration of sedatives has been linked to longer duration of mechanical ventilation and longer ICU length of stay.
Curtis N. Sessler, Katie M. Muzevich
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A simple and reliable conflict procedure for testing anti-anxiety agents
Psychopharmacologia, 1971The effects of three benzodiazepines (chlordiazepoxide, diazepam, and oxazepam), meprobamate, pentobarbital, d-amphetamine sulfate, magnesium pemoline, and scopolamine hydrobromide were studied with a simple conflict procedure in which thirsty naive rats were periodically administered shocks for licking water.
J R, Vogel, B, Beer, D E, Clody
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Chapter 1. Anti-Anxiety Agents and Sedative-Hypnotics
1985Publisher Summary In this chapter, the pharmacological actions of different anti-anxiety agents and sedative-aypnotics have been discussed with current references. Current evidence indicates that most anxiolytic and sedative-hypnotic drugs exert their pharmacological actions by binding to discrete neuronal recognition sites, consisting of ...
Barbara Petrack, Naokata Yokoyama
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Ondansetron: A Novel Anti-anxiety Agent
1991Although the widely used benzodiazepines for control of anxiety have met with high patient acceptance, there is a hesitation about long-term use owing to the possibility of dependence. The new azaspirodecanedione compounds such as buspirone (Buspar) are free from dependence but raise the spectre of tardive dyskinesia since they are derivatives of the ...
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Chapter 1. Antipsychotic and Anti-anxiety Agents
1970Publisher Summary This chapter discusses the results of studies focusing on antipsychotic and anti-anxiety agents. A double blind controlled study showed an approximately 10% better response in schizophrenic patients with droperidol than with haloperidol.
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