Results 161 to 170 of about 212,146 (193)
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Chapter 4. Anti-Anxiety Agents, Anticonvulsants, and Sedative-Hypnotics
1981Publisher Summary Rapid advances have been made in understanding the neurochemical mechanisms of benzodiazepines (BZs) and similar compounds responsible for their therapeutic actions. The “GABA hypothesis” relating to the actions of BZs in the brain continues to gain support.
Richard C. Effland, Manfred F. Försch
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Chapter 3. Anti-Anxiety Agents, Anticonvulsants and Sedative-Hypnotics
1978Publisher Summary A specific benzodiazepine receptor has been found in rat and human brain cells that might mediate their pharmacological activities. Binding sites in the rat are unevenly distributed throughout the brain, and a loose parallel between the pharmacological potency and receptor affinity is found.
William J. Houlihan, Gregory B. Bennett
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Chapter 32 Hypnotics and anti-anxiety agents
1997Summary Depression of the central nervous system can be achieved with a wide variety of chemical agents. Depending on dose, increasing levels of effect consisting of (a) anti-anxiety effects, (b) sedation, (c) sleep, (d) anesthesia, and (e) coma (with risk of a fatal outcome) may be produced. Frequently the same agent may be used at a greater dose to
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Chapter 2. Anti-Anxiety Agents, Anticonvulsants & Sedative-Hypnotics
1983Publisher Summary Studies on pharmacotherapy for anxiety continue to evolve along the dual paths of agents and actions. While benzodiazepines (BZs) continue to be the agents of choice for anxiolysis, new series of non-BZ compounds are emerging that may offer alternatives in the management of anxiety disorders.
Joseph P. Yevich +2 more
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Chapter 2. Anti-Anxiety Agents, Anticonvulsants and Sedative-Hypnotics
1977Publisher Summary This chapter describes the metabolic studies of Lorazepam in man and animals, Pinazepams in man, Diazepam in human kidney cortex microsomes and bile, and Nitrazepam in rabbit urine. N-desmethyldiazepam is a new human metabolite of chlorodiazepoxid, e.g Diazepam and its main active metabolite desmethyldiazepam, pass into the breast ...
W HOULIHAN, G BENNETT
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Behavioural Validation of a Light/Dark Choice Procedure for Testing Anti-Anxiety Agents
Behavioural Processes, 1989In order to teat the behavioural value of a two-chambered light/dark choice procedure used for pharmacological studies, we investigated the effects of several internal and external factors on two variables: the time spent by mice in the lit box (TLB) and the number of transitions between the lit box and the dark one.
R, Misslin, C, Belzung, E, Vogel
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Chapter 1. Antipsychotic and Anti-anxiety Agents
1966Publisher Summary This chapter discusses various antipsychotic and anti-anxiety agents. Most of the compounds discussed in the chapter are tested by two general methods: (1) the study of animal behavior following drug treatment in experimental models designed to mimic a clinical situation (conflict, avoidance, etc.) and (2) the measurement of ...
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Enhancement of 3H-diazepam binding by SQ 65,396: A novel anti-anxiety agent
Pharmacology Biochemistry and Behavior, 1978SQ 65,396, a clinically active anti-anxiety agent, enhanced the binding of 3H-diazepam at 1.5 nM. This effect was due to an increase in the affinity for the ligand, without a change in the number of 3H-diazepam binding sites. This action of SQ 65,396 may mediate its anti-anxiety effects by affecting the action of an endogenous modulator of the ...
B, Beer +3 more
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Anti-anxiety agents: duration of use and characteristics of users in the U.S.A.
Current Medical Research and Opinion, 1984A national survey of psychotherapeutic drug use was carried out in the U.S.A. in 1979. Data were obtained from a probability sample (n = 3161) of adults in the general population, using a clinically-oriented interview lasting an average of 90 minutes.
G D, Mellinger +2 more
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Animal models for the study of anti-anxiety agents: A review
Neuroscience & Biobehavioral Reviews, 1985Animal models for the study of anxiolytic agents are reviewed and evaluated according to pharmacological and behavioral criteria. Although there are important exceptions, in general, most early animal models have not provided a reliable basis for identifying compounds with potential anxiolytic action, or for delineating the mechanisms of anxiolytic ...
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