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Chapter 2: Anti-Anxiety Agents, Anticonvulsants, and Sedative-Hypnotics
Publisher Summary This chapter includes report of some novel structures of different compounds and its derivatives and analogs that continue to dominate the pharmacologically related areas of anti-anxiety, anticonvulsant, and sedative-hypnotic therapy.
Marvin Cohen
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AbstractDiazepam is one of the most widely used, broad‐spectrum anti‐anxiety agents. The aim of this study was to evaluate the efficacy of diazepam, and to establish whether it is more effective than a placebo in improving the various neurotic anxiety states seen in patients with neurosis or psychosomatic disease.
Ataru Inagaki+3 more
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NALOXONE POTENTIATES THE EFFECTS OF SUB-EFFECTIVE DOSES OF ANTI-ANXIETY AGENTS IN RATS AND MICE
Serge Barreau+2 more
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Anti-anxiety agents: a pharmacoepidemiological review [PDF]
The purpose of this review is to broaden the base for informed policy and to identify research issues to improve the utility of anti-anxiety agents. Data quality is discussed and the prevalence of morbid anxiety and the exposure to treatment with, and abuse of, anti-anxiety agents in different populations is presented.
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Animal models for the study of anti-anxiety agents: A review
Neuroscience & Biobehavioral Reviews, 1985Animal models for the study of anxiolytic agents are reviewed and evaluated according to pharmacological and behavioral criteria. Although there are important exceptions, in general, most early animal models have not provided a reliable basis for identifying compounds with potential anxiolytic action, or for delineating the mechanisms of anxiolytic ...
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The road to tranquility: The search for selective anti‐anxiety agents
Synapse, 1995AbstractThe earliest treatments of anxiety included cathartics and emetics, which were used to remove the excess of black bile (hence our word melancholia) thought to be responsible for the patient's demeanor. By the 1700s, physicians were prescribing drugs that are more selective for the CNS, chiefly opium and strengthening tonics.
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Chapter 1. Anti-Anxiety Agents and Sedative-Hypnotics
1985Publisher Summary In this chapter, the pharmacological actions of different anti-anxiety agents and sedative-aypnotics have been discussed with current references. Current evidence indicates that most anxiolytic and sedative-hypnotic drugs exert their pharmacological actions by binding to discrete neuronal recognition sites, consisting of ...
Barbara Petrack, Naokata Yokoyama
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