Results 221 to 230 of about 592,213 (353)

Neuroactive Phytochemicals as Multi-Target Modulators of Mental Health and Cognitive Function: An Integrative Review. [PDF]

Int J Mol Sci
Tkaczenko H, Buyun L, Kołodziejska R, Kamiński P, Kurhaluk N.   +4 more
europepmc   +1 more source

Abietic Acid Enhances the Sedative Activity of Diazepam: In vivo Approach along with Receptor Binding Affinity and Molecular Interaction with the GABAergic System

ChemistryOpen, EarlyView.
Abietic acid (AA) reveals potent sedative potential by expressing fast sleeping onset and increased sleeping duration compare to the control group in thiopental sodium induced sleeping mice. The compound also exhibited notable binding affinity (–7.9 kcal/mol) toward GABAA receptors.
Meher Afroz, Rubel Hasan, Mst Muslima Khatun, Mokammel Hossain Tito, Md Shadin, Ranjit Chakma, Mohammed Asiri, Faisal H. Altemani, Abdullah H. Altemani, Md Shimul Bhuia, Muhammad Torequl Islam   +10 more
wiley   +1 more source

Role of combination immunotherapy in restoring brain synergistic functional connectivity in patients with systemic lupus erythematosus without overt neuropsychiatric manifestations. [PDF]

Lupus Sci Med
Yang Y, Liu C, Liu S, Ding P, Bai R, Chen G, Li S, Song X, Cheng Y, Xu J.   +9 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Dexmedetomidine elicits a prolonged anxiolytic effect by inhibiting adrenergic neurons in the locus coeruleus in mice. [PDF]

Transl Psychiatry
Jiang L, Zhao J, Xia M, Song Y, Cao H, Wang Y, Huang S, Zhang Q, Huang H, Luo Y, Zhang Z, Yang Q.   +11 more
europepmc   +1 more source

Docosahexaenoic acid ameliorates autistic‐like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats

Pediatric Discovery, EarlyView.
The JNK pathway and oxidative stress are activated, and pro‐inflammatory cytokines are increased in neonatal maternal separation (NMS) rats. While docosahexaenoic acid treatment suppresses the activation of JNK pathway and oxidative stress, and reduces pro‐inflammatory cytokines release, thereby improving autism‐like behavior induced by NMS.
Boqing Xu, Hao Yuan, Xiaohuan Li, Qingyang Yu, Chunfang Dai, Zhifang Dong   +5 more
wiley   +1 more source

Characteristics and management of headache among psychiatric outpatients at a Japanese general hospital: A retrospective study with an exploratory CGRP case series. [PDF]

PCN Rep
Otani K, Imbe N, Shindo R.
europepmc   +1 more source

Predicting Pharmacological Treatment Response in Migraine Using AI/ML: A Scoping Review of the Evidence and Future Directions

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
ABSTRACT The treatment of migraine is hampered by inter‐individual variability, leading to an inefficient “trial and error” approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therapeutic outcomes.
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Porcine Corneal Tissue and Xenozoonotic Risks: A Review of the Current Evidence. [PDF]

Xenotransplantation
Moreira R, Nascimento H, Martins TMDM, Barbieri G, Pires P, Carvalho LN, Rosa LR, Almeida A, Pessuti CL, Ferrer H, Gomes JÁP, Goulart E, Raia S, Belfort R.   +13 more
europepmc   +1 more source

Ethnobotanical insights into the medicinal and food uses of Lamiaceae in the Mediterranean region: A systematic review and meta‐analysis

PLANTS, PEOPLE, PLANET, EarlyView.
Societal Impact Statement For generations, Mediterranean communities have used Lamiaceae or Labiatae plants like rosemary, thyme or mint to care for their health and to enrich their food. By bringing together dispersed knowledge from across the Mediterranean region, our review revealed the continuing relevance of Lamiaceae while also compiling past ...
Fuencisla Cáceres, Joan Vallès, Teresa Garnatje, Airy Gras   +3 more
wiley   +1 more source