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The road to tranquility: The search for selective anti‐anxiety agents
Synapse, 1995 AbstractThe earliest treatments of anxiety included cathartics and emetics, which were used to remove the excess of black bile (hence our word melancholia) thought to be responsible for the patient's demeanor. By the 1700s, physicians were prescribing drugs that are more selective for the CNS, chiefly opium and strengthening tonics.
J. Worth Estes
semanticscholar +4 more sources
Chapter 1. Antipsychotic and Anti-anxiety Agents
, 1966 Publisher Summary This chapter discusses various antipsychotic and anti-anxiety agents. Most of the compounds discussed in the chapter are tested by two general methods: (1) the study of animal behavior following drug treatment in experimental models designed to mimic a clinical situation (conflict, avoidance, etc.) and (2) the measurement of ...
Scott J. Childress
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Chapter 32 Hypnotics and anti-anxiety agents
, 1997 Summary Depression of the central nervous system can be achieved with a wide variety of chemical agents. Depending on dose, increasing levels of effect consisting of (a) anti-anxiety effects, (b) sedation, (c) sleep, (d) anesthesia, and (e) coma (with risk of a fatal outcome) may be produced. Frequently the same agent may be used at a greater dose to
Arthur Raines
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Behavioural Validation of a Light/Dark Choice Procedure for Testing Anti-Anxiety Agents
Behavioural Processes, 1989 In order to teat the behavioural value of a two-chambered light/dark choice procedure used for pharmacological studies, we investigated the effects of several internal and external factors on two variables: the time spent by mice in the lit box (TLB) and the number of transitions between the lit box and the dark one.
Rend Misslin +2 more
semanticscholar +4 more sources
Chapter 1. Antipsychotic and Anti-anxiety Agents
, 1972 Publisher Summary This chapter presents results of studies that analyze antipsychotic and antianxiety agents. The use of long-acting fluphenazine in the management of schizophrenia and its comparison with conventional therapy was reviewed. Studies of other 6-6-6 tricyclics included several new phenothiaaine derivatives. A diazabicyclononane analog of
Charles L. Zirkle, Carl Kaiser
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Chapter 1. Anti-Anxiety Agents and Sedative-Hypnotics
, 1985 Publisher Summary In this chapter, the pharmacological actions of different anti-anxiety agents and sedative-aypnotics have been discussed with current references. Current evidence indicates that most anxiolytic and sedative-hypnotic drugs exert their pharmacological actions by binding to discrete neuronal recognition sites, consisting of ...
Barbara Petrack, Naokata Yokoyama
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Prediction of Response to Anti-Anxiety Agents
, 1979 Cosmo Hallström, M Lader
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Animal models for the study of anti-anxiety agents: A review
Neuroscience & Biobehavioral Reviews, 1985Animal models for the study of anxiolytic agents are reviewed and evaluated according to pharmacological and behavioral criteria. Although there are important exceptions, in general, most early animal models have not provided a reliable basis for identifying compounds with potential anxiolytic action, or for delineating the mechanisms of anxiolytic ...
D. Treit
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