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Chapter 3 Anti-Anxiety Agents, Anticonvulsants, and Sedative-Hypnotics
, 1979 Publisher Summary This chapter summarizes the nature of the benzodiazepine receptor that has been characterized further, by the demonstration that a single class of binding sites exists in rat brain for a structurally diverse series of benzodiazepines.
Joel G. Berger, Louis C. Iorio
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Behavioural Validation of a Light/Dark Choice Procedure for Testing Anti-Anxiety Agents
Behavioural Processes, 1989In order to teat the behavioural value of a two-chambered light/dark choice procedure used for pharmacological studies, we investigated the effects of several internal and external factors on two variables: the time spent by mice in the lit box (TLB) and the number of transitions between the lit box and the dark one.
Catherine Belzung +2 more
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The road to tranquility: The search for selective anti‐anxiety agents
Synapse, 1995AbstractThe earliest treatments of anxiety included cathartics and emetics, which were used to remove the excess of black bile (hence our word melancholia) thought to be responsible for the patient's demeanor. By the 1700s, physicians were prescribing drugs that are more selective for the CNS, chiefly opium and strengthening tonics.
J. Estes
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Chapter 1. Anti-Anxiety Agents and Sedative-Hypnotics
1985Publisher Summary In this chapter, the pharmacological actions of different anti-anxiety agents and sedative-aypnotics have been discussed with current references. Current evidence indicates that most anxiolytic and sedative-hypnotic drugs exert their pharmacological actions by binding to discrete neuronal recognition sites, consisting of ...
Barbara Petrack, Naokata Yokoyama
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Chapter I. Antipsychotic and Anti-anxiety Agents
, 1968 Publisher Summary This chapter elaborates on antipsychotic and antianxiety agents. The reported contribution of pyrrole nuclei to the sedative action of ketone derivatives encouraged the synthesis of relatives of ketone derivatives in which the benzene ring was replaced by pyrrole.
Irwin J. Pachter, Alan A. Rubin
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Chapter 2. Anti-Anxiety Agents, Anticonvulsants & Sedative-Hypnotics
, 1983 Publisher Summary Studies on pharmacotherapy for anxiety continue to evolve along the dual paths of agents and actions. While benzodiazepines (BZs) continue to be the agents of choice for anxiolysis, new series of non-BZ compounds are emerging that may offer alternatives in the management of anxiety disorders.
Joseph P. Yevich +2 more
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Chapter 2: Anti-Anxiety Agents, Anticonvulsants, and Sedative-Hypnotics
, 1976 Publisher Summary This chapter includes report of some novel structures of different compounds and its derivatives and analogs that continue to dominate the pharmacologically related areas of anti-anxiety, anticonvulsant, and sedative-hypnotic therapy.
Marvin Cohen
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Human Psychopharmacology: Clinical and Experimental, 2003 AbstractDiazepam is one of the most widely used, broad‐spectrum anti‐anxiety agents. The aim of this study was to evaluate the efficacy of diazepam, and to establish whether it is more effective than a placebo in improving the various neurotic anxiety states seen in patients with neurosis or psychosomatic disease.
Toshiya Inada +3 more
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Medicinal chemistry, 2021 BACKGROUND Iminostilbene and 1,2,3-triazole ring containing compounds are considered as beneficial substrates in drug design. OBJECTIVES This study was aimed at the synthesis of novel series of iminostilbene linked 1,2,3- triazole pharmacophores (7c-n)
Kariyappa N. Ankali +3 more
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