Results 241 to 250 of about 118,647 (313)

Kv7 and K2P Potassium Channels in Thalamocortical Function and Their Therapeutic Potential in Childhood Absence Epilepsy

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Modulation of K2P and Kv7 channels has the potential to reduce hyperexcitability and hypersynchronicity within the thalamocortical system. This offers a new avenue to suppress spike and wave discharges, the electrophysiological hallmark of absence epilepsy.
Anushka Takhi, Guiscard Seebohm, Thomas Budde, Annika Lüttjohann   +3 more
wiley   +1 more source

T-World Virtual Human Cardiomyocyte. II. Organ-Scale Simulations and Applications. [PDF]

Circ Res
Tomek J, Holmes M, Martinez-Navarro H, Zhou X, Hasaballa AI, Wang ZJ, Arantes Berg L, Bertrand A, Colman MA, Bueno-Orovio A, Bers DM, Rodriguez B, Heijman J.   +12 more
europepmc   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Inotrope selection in mixed cardiogenic shock with sepsis: a comparative analysis between milrinone and dobutamine. [PDF]

Ann Am Thorac Soc
Li B, Gershengorn HB, Vail EA, Wunsch H, Walkey AJ, Law AC, Ko D, Ayalon N, Kearney CM, Bosch NA.   +9 more
europepmc   +1 more source

Do nonsteroidal anti-inflammatory drugs increase the risk of atrial fibrillation after non-cardiac surgery? Insights from translational and clinical research. [PDF]

J Anesth Analg Crit Care
Laou E, Mitta S, Voutsadaki E, Ntalarizou N, Tselioti P, Cortegiani A, Chalkias A.   +6 more
europepmc   +1 more source

Synergistic antiarrhythmic mechanism of I_Na-L and RyR2 blockade: normalization of pathological calcium cycling and CaMKII signaling. [PDF]

J Transl Med
Ju M, Qiu S, Wang Y, Wu W, Sun J, Shi C, Jia Q, Xu Y.   +7 more
europepmc   +1 more source

The Cardiovascular Effects of Inflammatory Bowel Disease Therapy with Biologics and Small Molecules: A Comprehensive Review. [PDF]

J Clin Med
Mastoridou EM, Fousekis FS, Sakellariou XM, Mpakogiannis K, Nikas DN, Michalis LK, Katsanos KH, Milionis H.   +7 more
europepmc   +1 more source

Incremental benefits of catheter ablation in patients with structural heart disease undergoing implantable cardioverter-defibrillator therapy for ventricular arrhythmias: A PRISMA compliant systematic review and meta analysis. [PDF]

Medicine (Baltimore)
Amir M, Hassan A, Ali EF, Noor M, Nazir A, Kamran M, Rizwan A, Fahim MA, Usman M, Awais MN, Waleed M, Tahir MU, Khan MH, Haroon A.   +13 more
europepmc   +1 more source

Cardiovascular and Thromboembolic Safety Signals Associated with Non-Steroidal Anti-Inflammatory Drugs Initiation: A Sequence Symmetry Analysis

Bobba SS, Rowlands E, Delmestri A, Man WY, Chen X, Li X, Saura-Lazaro A, Alhambra DP, Newby D.   +8 more
europepmc   +1 more source