Results 21 to 30 of about 48,847 (353)

Cardiac TdP risk stratification modelling of anti-infective compounds including chloroquine and hydroxychloroquine

Royal Society Open Science, 2021
Hydroxychloroquine (HCQ), the hydroxyl derivative of chloroquine (CQ), is widely used in the treatment of rheumatological conditions (systemic lupus erythematosus, rheumatoid arthritis) and is being studied for the treatment and prevention of COVID-19 ...
Dominic G. Whittaker, Rebecca A. Capel, Maurice Hendrix, Xin Hui S. Chan, Neil Herring, Nicholas J. White, Gary R. Mirams, Rebecca-Ann B. Burton   +7 more
doaj   +1 more source

Successful rescue of fulminant myocarditis with mechanical circulatory support and immunosuppression therapy: A case report

Frontiers in Cardiovascular Medicine, 2023
Myocarditis is challenging to diagnose because of its various clinical manifestations. Fulminant myocarditis (FM) is a severe type of myocarditis characterized by heart failure, malignant arrhythmia, cardiogenic shock, and cardiac arrest.
Chi Zhou
doaj   +1 more source

Efficacy of pimobendan in the prevention of congestive heart failure or sudden death in doberman pinschers with preclinical dilated cardiomyopathy (the PROTECT study) [PDF]

, 2012
<p>Background: The benefit of pimobendan in delaying the progression of preclinical dilated cardiomyopathy (DCM) in Dobermans is not reported.</p> <p>Hypothesis: That chronic oral administration of pimobendan to Dobermans with ...
Boswood, A., Braz-Ruivo, L., Culshaw, G.J., Dukes-McEwan, J., Estrada, A., French, A.T., Gordon, S.G., Loureiro, J., O'Grady, M.R., O'Sullivan, M.L., Oyama, M.A., Patteson, M., Smith, A., Summerfield, N.T., Watson, P.J., Willis, R.   +15 more
core   +3 more sources

Cardiovascular Abnormalities in Juvenile Dermatomyositis: A Scoping Review for the Clinical Rheumatologists

Frontiers in Medicine, 2022
Juvenile dermatomyositis (JDM) is a common form of inflammatory myositis in children. Vasculopathy and endothelial dysfunction play significant roles in the pathogenesis of JDM.
Sanjib Mondal, Prabal Barman, Pandiarajan Vignesh   +2 more
doaj   +1 more source

Sex‐specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles [PDF]

, 2018
Sex has a large influence on cardiac electrophysiological properties. Whether sex differences exist in apamin‐sensitive small conductance Ca2+‐activated K+ (SK) current (IKAS) remains unknown.
Chen, Mu, Chen, Peng-Sheng, Chen, Zhenhui, Everett, Thomas H., IV, Guo, Shuai, Lin, Shien-Fong, Rubart-von der Lohe, Michael, Wang, Zhuo, Weiss, James N., Xu, Dong-Zhu, Yin, Dechun   +10 more
core   +1 more source

Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?

Frontiers in Physiology, 2017
Anti-arrhythmic drugs are a mainstay in the management of symptoms related to arrhythmias, and are adjuncts in prevention and treatment of life-threatening ventricular arrhythmias.
Jem D. Lane, Jem D. Lane, Andrew Tinker
doaj   +1 more source

Cardioprotective effects of Ferulic acid against various drugs and toxic agents

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Homeostatic regulation of cardiomyocytes is indispensable in maintaining the normal physiological activity of cardiac tissue. Cardiotoxicity induced by drugs may lead to cardiac abnormalities such as arrhythmia, myocardial infarction and ...
Anandakumar Pandi, Mahto Hemanti Raghu, Naveenkumar Chandrashekar, Vanitha Manickam Kalappan   +3 more
doaj   +1 more source

A K_ATP channel opener inhibited myocardial reperfusion action potential shortening and arrhythmias [PDF]

, 2001
Low concentrations of certain K_ATP channel openers have been reported to exert a moderate inhibitory effect on arrhythmias during post-ischaemic early myocardial reperfusion, but the accompanying effects on the time course of ...
MacKenzie, I., Northover, B.J., Workman, A.J.   +2 more
core   +1 more source

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats [PDF]

, 2015
Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in ...
Choisy, Stéphanie C., Choisy, Stéphanie C., Hancox, Jules C., James, Andrew F., Jones, Sandra A., Kim, Shang-Jin   +5 more
core   +1 more source

Role of Heat Shock Proteins in Atrial Fibrillation: From Molecular Mechanisms to Diagnostic and Therapeutic Opportunities

Cells, 2022
Heat shock proteins (HSPs) are endogenous protective proteins and biomarkers of cell stress response, of which examples are HSP70, HSP60, HSP90, and small HSPs (HSPB).
Daiqi Liu, Xuyao Han, Zhiwei Zhang, Gary Tse, Qingmiao Shao, Tong Liu   +5 more
doaj   +1 more source