Results 31 to 40 of about 3,383,893 (307)

Peripheral Anti-nociceptive and Anti-inflammatory Effect of OleanoliAcid in a Rat Model of Osteoarthritis [PDF]

, 2021
Background: Oleanolic acid (OA) is a naturally occurring pentacyclic triterpenoid with multifarious actions. The anti-inflammatory effect it exerts when taken orally is the most important; however, the underpinning mechanisms of such effects have not yet
Fouani, Malak, Fakhoury, Marc, Salman, Israa, Lawand, Nada Bashir   +3 more
core   +1 more source

Have the Findings from Clinical Risk Prediction and Trials Any Key Messages for Safety Pharmacology?

Frontiers in Physiology, 2017
Anti-arrhythmic drugs are a mainstay in the management of symptoms related to arrhythmias, and are adjuncts in prevention and treatment of life-threatening ventricular arrhythmias.
Jem D. Lane, Jem D. Lane, Andrew Tinker
doaj   +1 more source

Successful rescue of fulminant myocarditis with mechanical circulatory support and immunosuppression therapy: A case report

Frontiers in Cardiovascular Medicine, 2023
Myocarditis is challenging to diagnose because of its various clinical manifestations. Fulminant myocarditis (FM) is a severe type of myocarditis characterized by heart failure, malignant arrhythmia, cardiogenic shock, and cardiac arrest.
Chi Zhou
doaj   +1 more source

Case Report: Nadolol–mexiletine combination therapy for refractory neonatal long QT syndrome: a case series beyond sodium channelopathies

Frontiers in Pediatrics
Neonatal long QT syndrome (LQTS) is associated with substantial mortality and poses significant therapeutic challenges, particularly in cases refractory to beta-blocker monotherapy.
Jihye You, Jihye You, Hyun Ho Kim
doaj   +1 more source

Cardiovascular Abnormalities in Juvenile Dermatomyositis: A Scoping Review for the Clinical Rheumatologists

Frontiers in Medicine, 2022
Juvenile dermatomyositis (JDM) is a common form of inflammatory myositis in children. Vasculopathy and endothelial dysfunction play significant roles in the pathogenesis of JDM.
Sanjib Mondal, Prabal Barman, Pandiarajan Vignesh   +2 more
doaj   +1 more source

Cardioprotective effects of Ferulic acid against various drugs and toxic agents

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Homeostatic regulation of cardiomyocytes is indispensable in maintaining the normal physiological activity of cardiac tissue. Cardiotoxicity induced by drugs may lead to cardiac abnormalities such as arrhythmia, myocardial infarction and ...
Anandakumar Pandi, Mahto Hemanti Raghu, Naveenkumar Chandrashekar, Vanitha Manickam Kalappan   +3 more
doaj   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

Arrhythmia Classification Based on Combined Chaotic and Statistical Feature Extraction [PDF]

, 2018
Obvious information content in Electro cardio graph has become mandatory to reveal the abnormalities in the heart functions. Arrhythmia is commonly seen heart disorder and results in fatal end, if not identified and treated properly within time limits ...
S, Pushpa, S. Pushpa, G, Jayagopi, G. Jayagopi   +3 more
core   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Role of Heat Shock Proteins in Atrial Fibrillation: From Molecular Mechanisms to Diagnostic and Therapeutic Opportunities

Cells, 2022
Heat shock proteins (HSPs) are endogenous protective proteins and biomarkers of cell stress response, of which examples are HSP70, HSP60, HSP90, and small HSPs (HSPB).
Daiqi Liu, Xuyao Han, Zhiwei Zhang, Gary Tse, Qingmiao Shao, Tong Liu   +5 more
doaj   +1 more source