Results 51 to 60 of about 46,906 (308)

Sodium-glucose transporter 2 inhibitors and their antiarrhythmic role: New insights and future perspective

Acta Marisiensis - Seria Medica
Sodium-glucose transporter 2 inhibitors have been identified as pleiotropic pharmacological agents with demonstrated efficacy in a wide range of pathologies.
Prația-Aron Diana-Ioana, Cozac Dan-Alexandru, Scridon Alina   +2 more
doaj   +1 more source

Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review

Journal of Cardiothoracic Surgery, 2010
Atrial Fibrillation (AF) is the most common arrhythmia occurring after cardiac surgery. Its incidence varies depending on type of surgery. Postoperative AF may cause hemodynamic deterioration, predispose to stroke and increase mortality.
Baikoussis Nikolaos G, Rogkakou Christina, Apostolakis Efstratios, Koniari Ioanna, Dougenis Dimitrios   +4 more
doaj   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Choosing a class IC antiarrhythmic drug for the treatment of patients without structural heart disease: clinical advantages of the most common agents (literature review)

Сучасні медичні технології
Aim: to analyze the pharmacological features and updated evidence-based medicine data of Class IC antiarrhythmic drug (AAD) ethacizine compared to propafenone to optimize the choice of treatment for cardiac arrhythmias in patients without structural ...
N. M. Sydorova, M. Yu. Kolesnyk
doaj   +1 more source

A Case for Pharmacogenomics in Management of Cardiac Arrhythmias

Indian Pacing and Electrophysiology Journal, 2012
Disorders of the cardiac rhythm are quite prevalent in clinical practice. Though the variability in drug response between individuals has been extensively studied, this information has not been widely used in clinical practice.
Gaurav Kandoi, Anjali Nanda, Vinod Scaria, Sridhar Sivasubbu   +3 more
doaj   +1 more source

Redefining the Incidence and Profile of Fluoropyrimidine-Associated Cardiotoxicity in Cancer Patients: A Systematic Review and Meta-Analysis

Pharmaceuticals, 2023
Aim: The cardiac toxicity that occurs during administration of anti-tumor agents has attracted increasing concern. Fluoropyrimidines have been used for more than half a century, but their cardiotoxicity has not been well clarified.
Yajie Lu, Wei Pan, Shizhou Deng, Qiongyi Dou, Xiangxu Wang, Qiang An, Xiaowen Wang, Hongchen Ji, Yue Hei, Yan Chen, Jingyue Yang, Hong-Mei Zhang   +11 more
doaj   +1 more source

Prevalence of and Risk Factors for Paroxysmal Atrial Fibrillation in Patients with Cardiovascular Disease but without diagnosed Atrial Fibrillation [PDF]

, 2019
学位記番号 ...
Niijima, Katsura, ニイジマ, カツラ, 新島, 桂   +2 more
core  

The 9th International RASopathies Symposium

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel, Lisa Schoyer, Beth Stronach, Raya Bogdanova, Anton M. Bennett, Jaishri Blakeley, Miriam Bornhorst, Tammy Bowers, Saskia M. Brachmann, Emma Burkitt‐Wright, Kathryn Chatfield, Alessandro De Luca, Khalil El‐Chammas, Abdul Elkadri, John E. Fortunato, Bruce D. Gelb, Anne Goriely, Karen Gripp, Kassidy Grover, Lindsay Homan, Kenneth A. Kern, Maija Kiuru, Charles (Chuck) Lawson, Yong‐Seok Lee, Frank McCormick, Gina Ney, Cristina Nuevo‐Tapioles, Sara Pardej, Elizabeth I. Pierpont, Julia Plank, Nancy Ratner, Katherine A. Rauen, J. Elliott Robinson, Les Rogers, Sarah E. Sheppard, Keir Shiels, David Stevenson, Dagmar Tiemens, Matthew Traylor, K. Nicole Weaver, Marielle Yohe, Tamar Green   +41 more
wiley   +1 more source

Lead optimisation of dehydroemetine for repositioned use in malaria [PDF]

, 2020
Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Abubaker, M, Bryce, RA, Burusco, KK, Fernández-Álvaro, E, Gutnov, A, Matthews, H, Nirmalan, NJ, Panwar, P, Wilkinson, JA   +8 more
core   +3 more sources

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source