Results 41 to 50 of about 118,647 (313)

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source

Sodium-glucose transporter 2 inhibitors and their antiarrhythmic role: New insights and future perspective

Acta Marisiensis - Seria Medica
Sodium-glucose transporter 2 inhibitors have been identified as pleiotropic pharmacological agents with demonstrated efficacy in a wide range of pathologies.
Prația-Aron Diana-Ioana, Cozac Dan-Alexandru, Scridon Alina   +2 more
doaj   +1 more source

Research Progress on Effects of Ginsenoside Rg2 and Rh1 on Nervous System and Related Mechanisms

Molecules, 2023
Neurological-related disorders are diseases that affect the body’s neurons or peripheral nerve tissue, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD).
Silu Liu, Weijia Chen, Yan Zhao, Ying Zong, Jianming Li, Zhongmei He   +5 more
doaj   +1 more source

Thymulin: An emerging anti-inflammatory molecule

, 2005
Thymulin is a neuroendocrine hormone with immunoregulatory actions. Originally known as 'serum thymic factor' (FTS), thymulin binds to a carrier protein and zinc (Zn2+) to exert its biologic properties.
Haddad J.J., Safieh-Garabedian B., Saade N.E.   +2 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review

Journal of Cardiothoracic Surgery, 2010
Atrial Fibrillation (AF) is the most common arrhythmia occurring after cardiac surgery. Its incidence varies depending on type of surgery. Postoperative AF may cause hemodynamic deterioration, predispose to stroke and increase mortality.
Baikoussis Nikolaos G, Rogkakou Christina, Apostolakis Efstratios, Koniari Ioanna, Dougenis Dimitrios   +4 more
doaj   +1 more source

Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae) [PDF]

, 2013
BACKGROUND: Malaria, trypanosomiasis and leishmaniasis have an overwhelming impact in the poorest countries in the world due to their prevalence, virulence and drug resistance ability.
Swaleh, S. M., Hassanali, Ahmed, Ndiege, Isaiah O, Brun, R., Dalsgaard, Petur, Ahmed Hassanali, Ndiege, I. O., Malebo, Hamisi M, Monical Cal, Petur Dalsgaard, Maurice O Omolo, Hassanali, A., Wenzler, T., Sequin, U., Hamburger, M., Wenzler, Tanja, Tanja Wenzler, Omolo, M. O., Omolo, Maurice O, Hamisi M Malebo, Dalsgaard, P., Cal, M., Häussinger, Daniel, Daniel Häussinger, Häussinger, D., Hamburger, Matthias, Brun, Reto, Sauda M Swaleh, Malebo, H. M., Séquin, Urs, Isaiah O Ndiege, Reto Brun, Cal, Monical, Swaleh, Sauda M, Urs Séquin, Matthias Hamburger   +35 more
core   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Choosing a class IC antiarrhythmic drug for the treatment of patients without structural heart disease: clinical advantages of the most common agents (literature review)

Сучасні медичні технології
Aim: to analyze the pharmacological features and updated evidence-based medicine data of Class IC antiarrhythmic drug (AAD) ethacizine compared to propafenone to optimize the choice of treatment for cardiac arrhythmias in patients without structural ...
N. M. Sydorova, M. Yu. Kolesnyk
doaj   +1 more source

A Case for Pharmacogenomics in Management of Cardiac Arrhythmias

Indian Pacing and Electrophysiology Journal, 2012
Disorders of the cardiac rhythm are quite prevalent in clinical practice. Though the variability in drug response between individuals has been extensively studied, this information has not been widely used in clinical practice.
Gaurav Kandoi, Anjali Nanda, Vinod Scaria, Sridhar Sivasubbu   +3 more
doaj   +1 more source