Results 21 to 30 of about 28,292 (266)

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Role of Heat Shock Proteins in Atrial Fibrillation: From Molecular Mechanisms to Diagnostic and Therapeutic Opportunities

Cells, 2022
Heat shock proteins (HSPs) are endogenous protective proteins and biomarkers of cell stress response, of which examples are HSP70, HSP60, HSP90, and small HSPs (HSPB).
Daiqi Liu, Xuyao Han, Zhiwei Zhang, Gary Tse, Qingmiao Shao, Tong Liu   +5 more
doaj   +1 more source

Conjugated Porphyrin Polymer With Superior Charge Transfer for Photodynamic‐Immunomodulatory Prevention of CIED Infection in Diabetes

Advanced Healthcare Materials, EarlyView.
Under NIR irradiation, PTCPP generates ROS to eliminate MRSA biofilms and promote M1 macrophage polarization for phagocytosis. After bacterial clearance, the material is phagocytosed by macrophages, shifting their polarization to M2 phenotype via metabolic reprogramming, which synergistically enhances anti‐infection therapy and wound healing.
Honghao Ma, Jinguo Xu, Rongrong Gu, Chuanhui Dong, Te Chen, Yi Mu, Jing Zhu, Yating Wang, Wen Wang, Yingying Zhang, Hongyu Ma, Xiaochen Wang, Sheng Ye, Cheng Cheng   +13 more
wiley   +1 more source

The Hyperpolarization-Activated Cyclic-Nucleotide-Gated Channel Blocker Ivabradine Does Not Prevent Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia

Frontiers in Pharmacology, 2020
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, stressed-provoked ventricular arrhythmia. CPVT is treated by β-adrenergic receptor blockers, Na+ channel inhibitors, sympathetic denervation, or by implanting a defibrillator ...
Hanna Bueno-Levy, David Weisbrod, Dor Yadin, Shiraz Haron-Khun, Shiraz Haron-Khun, Asher Peretz, Edith Hochhauser, Michael Arad, Bernard Attali   +8 more
doaj   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab

Frontiers in Physiology, 2021
BackgroundCombined treatment with anthracyclines (e.g., doxorubicin; Dox) and trastuzumab (Trz), a humanized anti-human epidermal growth factor receptor 2 (HER2; ErbB2) antibody, in patients with HER2-positive cancer is limited by cardiotoxicity, as ...
Claudia Altomare, Alessandra Maria Lodrini, Alessandra Maria Lodrini, Giuseppina Milano, Giuseppina Milano, Vanessa Biemmi, Edoardo Lazzarini, Sara Bolis, Sara Bolis, Nicolò Pernigoni, Eleonora Torre, Martina Arici, Mara Ferrandi, Lucio Barile, Lucio Barile, Lucio Barile, Marcella Rocchetti, Giuseppe Vassalli, Giuseppe Vassalli, Giuseppe Vassalli   +19 more
doaj   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Management of Cardiac Arrhythmias in the Emergency Department of a Tertiary Care Hospital in Colombia

Revista de Investigación e Innovación en Ciencias de la Salud
Introduction. Cardiac arrhythmias represent a diagnostic and therapeutic challenge in emergency departments. Objective. To describe the diagnostic accuracy and management practices of cardiac arrhythmias in the emergency department of a tertiary ...
Alejandro Ceballos-Rivera, Angie Tatiana Portocarrero-Angulo, Catalina Rios-Caviedes, Dayana Liseth Aristizabal-Villegas, Liz Valentina Jordan-Moya, Efraín Santiago Guzmán-Bedoya, Daniel Arias-Jaramillo, Andrés Gaviria-Mendoza   +7 more
doaj   +1 more source

Symptomatic Myocardial Bridging Treated by Coronary Stenting

Majalah Kardiologi Indonesia, 2014
Background : Myocardial bridging is a congenital coronary anomaly with mostly benign course throughout life. However, several pathological clinical manifestations may accompany myocardial bridging, such as arrhythmia, angina, depressed left ventricular ...
Johan Winata, Eben Reppi, Bambang Budiono, Reggy L Lefrandt   +3 more
doaj   +1 more source

Molecular Insights in Atrial Fibrillation Pathogenesis and Therapeutics: A Narrative Review

Diagnostics, 2021
The prevalence of atrial fibrillation (AF) is bound to increase globally in the following years, affecting the quality of life of millions of people, increasing mortality and morbidity, and beleaguering health care systems.
Konstantinos A. Papathanasiou, Sotiria G. Giotaki, Dimitrios A. Vrachatis, Gerasimos Siasos, Vaia Lambadiari, Konstantinos E. Iliodromitis, Charalampos Kossyvakis, Andreas Kaoukis, Konstantinos Raisakis, Gerasimos Deftereos, Theodore G. Papaioannou, Georgios Giannopoulos, Dimitrios Avramides, Spyridon G. Deftereos   +13 more
doaj   +1 more source