Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs +6 more
wiley +1 more source
Biologic Therapy in Severe Asthma: A Phenotype-Driven and Targeted Approach. [PDF]
D'Amato M +11 more
europepmc +1 more source
Systematic review (51 studies; 547 patients) indicates dupilumab may unmask/worsen CTCL (mainly MF/SS). A French Delphi consensus recommends rigorous diagnostic workup, avoiding dupilumab in confirmed CTCL, discontinuing upon diagnosis, and favouring methotrexate or phototherapy.
Florent Amatore +8 more
wiley +1 more source
Soufeng Yuchuan formula alleviates asthma airway inflammation and suppresses the progression of asthma by inhibiting ferroptosis in airway epithelial cells. [PDF]
Mumu W +4 more
europepmc +1 more source
Research on the regulation of gut microbiota homeostasis and immune function in asthmatic mice by Huanglong Zhixiao Formula. [PDF]
Chen YX +8 more
europepmc +1 more source
Ferroptosis-immune-metabolic axis in asthma: mechanistic crosstalk, endotype-specific regulation, and translational targeting. [PDF]
Ni FX +5 more
europepmc +1 more source
Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma. [PDF]
Wieczfinska J, Pawliczak R.
europepmc +1 more source
The Architecture of Deep Phenotyping in Asthma: Integrating Molecular, Metabolic, and Neuro-Hormonal Endotypes. [PDF]
Demenciuc N +9 more
europepmc +1 more source
Dectin-1 epigenetic reprogramming rescues senescent-like Treg function in allergic asthma. [PDF]
Sun X +7 more
europepmc +1 more source

