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Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents [PDF]
Bioorganic Chemistry, 2021 Phosphodiesterase (PDE) inhibitors are currently an extensively studied group of compounds that can bring many benefits in the treatment of various inflammatory and fibrotic diseases, including asthma.
Katarzyna Wójcik-Pszczoła +2 more
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Structure of nedocromil sodium: a novel anti-asthmatic agent
Acta Crystallographica Section C Crystal Structure Communications, 1987C 19 H 15 NO 7 2− •2Na + •3H 2 O cristallise dans le systeme triclinique avec le groupe d'espace P2 1 /n.
A. A. Freer +2 more
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Experimental study of a potential anti-asthmatic agent: SCH 15280.
The Journal of Pharmacology and Experimental Therapeutics, 1975A forced oscillations technique for measuring total respiratory system resistance was used to quantitate the bronchomotor activity of Sch 15280: (5[4-(N-methyl)-piperidylidine]5H-[1]-benzopyrano[2,3,b]-pyridine maleate) and to compare its potency to that of standard bronchodilator agents.
L, Diamond +3 more
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Protective Effect of a New Anti‐Asthmatic Agent (Minocromil) in Bronchial Allergen Challenge Tests
Allergy, 1985Ten patients were included in a double‐blind crossover trial, designed to compare the effects of a new anti‐asthmatic agent Minocromil, an organic decarboxylic acid, and placebo on bronchial allergen challenge. The challenges were performed at weekly intervals.
U G, Svendsen +3 more
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Respirology, 2004
Objectives: Inhaled corticosteroids, leukotriene receptor antagonists, and theophylline are recommended for the treatment of mild persistent asthma. The aim of this study was to compare the changes in sputum total cell and eosinophil counts, and eosinophil cationic protein (ECP) levels in serum and sputum following treatment with leukotriene receptor ...
Ozkara, SEVGİYE +5 more
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Objectives: Inhaled corticosteroids, leukotriene receptor antagonists, and theophylline are recommended for the treatment of mild persistent asthma. The aim of this study was to compare the changes in sputum total cell and eosinophil counts, and eosinophil cationic protein (ECP) levels in serum and sputum following treatment with leukotriene receptor ...
Ozkara, SEVGİYE +5 more
openaire +3 more sources
Bioorganic & Medicinal Chemistry, 2006
The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route.
Lawson, E C +10 more
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The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route.
Lawson, E C +10 more
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Clinical & Experimental Allergy, 2005
SummaryBackground Dendritic cells (DCs) play an important role in the immune response and are critically involved in asthma. β2‐agonists could potentially exacerbate type 2 T helper (Th2) cell‐mediated immune response.Objectives To determine the effects of various anti‐asthmatic agents on DCs function both in vitro and in vivo.Methods
I, Machida +8 more
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SummaryBackground Dendritic cells (DCs) play an important role in the immune response and are critically involved in asthma. β2‐agonists could potentially exacerbate type 2 T helper (Th2) cell‐mediated immune response.Objectives To determine the effects of various anti‐asthmatic agents on DCs function both in vitro and in vivo.Methods
I, Machida +8 more
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Chapter 14: List of principal anti-asthmatic agents
Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology, 2022Yoshiyuki Yamada, Yuichi Adachi
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Bronchodilating effect of KC-404, a novel anti-asthmatic agent, and its derivatives in monkey.
Archives internationales de pharmacodynamie et de therapie, 1987The inhibitory effect of 3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine (KC-404) on aerosolized methacholine- and histamine-induced increase in total respiratory resistance (Rrs) was determined in monkeys using the forced 3 Hz oscillation method and was compared with the effect of aminophylline.
S, Mue +7 more
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