Results 281 to 290 of about 30,075 (311)

The anti-asthmatic agent KC 404 inhibits sodium absorption by canine tracheal epithelium.

open access: closedResearch communications in chemical pathology and pharmacology, 1992
To elucidate the effect of KC 404, an anti-asthmatic agent, on electrolyte transport across airway mucosa, we studied electrical properties of canine tracheal epithelium under isometric conditions in vitro. Addition of KC 404 decreased short-circuit current, transepithelial potential difference and cell conductance, accompanied by the decrease in 22Na ...
J, Tamaoki   +4 more
openaire   +2 more sources
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Protective Effect of a New Anti‐Asthmatic Agent (Minocromil) in Bronchial Allergen Challenge Tests

Allergy, 1985
Ten patients were included in a double‐blind crossover trial, designed to compare the effects of a new anti‐asthmatic agent Minocromil, an organic decarboxylic acid, and placebo on bronchial allergen challenge. The challenges were performed at weekly intervals.
Flemming Madsen   +3 more
openaire   +3 more sources

Synthesis and biological evaluation of Ginsenoside Compound K analogues as a novel class of anti-asthmatic agents

Bioorganic & Medicinal Chemistry Letters, 2019
Ginsenoside Compound K (CK) showed potent activity against IgE for the treatment of asthma. A series of CK analogues were then synthesized by straightforward procedures. The in vivo anti-IgE activity evaluations using the OVA-induced asthmatic mouse model revealed preliminary SARs of the CK analogues, which showed that the sugar type, modifications on ...
Sumei Ren   +4 more
openaire   +2 more sources

Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent

Bioorganic & Medicinal Chemistry, 2006
The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route.
Lawson, E C   +10 more
openaire   +4 more sources

Commentary on Japanese Pediatric Guideline for the Treatment and Management of Asthma 2017 Chapter 14 List of principal anti-asthmatic agents

open access: closedNihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology, 2019
Yoshiyuki Yamada, Hirokazu Arakawa
openaire   +3 more sources

Salicylic acid derivatives as potential anti asthmatic agents using disease responsive drug delivery system for prophylactic therapy of allergic asthma

Medical Hypotheses, 2016
Asthma is a multi-factorial and complicated lung disorder of the immune system which has expanded to a wider ambit unveiling its etiology to be omnipresent at both ends of the spectrum involving basic pharmacology and in-depth immunology. As asthma occurs through triggered activation of various immune cells due to different stimuli, it poses a great ...
Kalidhindi Rama Satyanarayana Raju   +8 more
openaire   +3 more sources

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