Results 281 to 290 of about 30,075 (311)
The anti-asthmatic agent KC 404 inhibits sodium absorption by canine tracheal epithelium.
To elucidate the effect of KC 404, an anti-asthmatic agent, on electrolyte transport across airway mucosa, we studied electrical properties of canine tracheal epithelium under isometric conditions in vitro. Addition of KC 404 decreased short-circuit current, transepithelial potential difference and cell conductance, accompanied by the decrease in 22Na ...
J, Tamaoki+4 more
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Protective Effect of a New Anti‐Asthmatic Agent (Minocromil) in Bronchial Allergen Challenge Tests
Allergy, 1985Ten patients were included in a double‐blind crossover trial, designed to compare the effects of a new anti‐asthmatic agent Minocromil, an organic decarboxylic acid, and placebo on bronchial allergen challenge. The challenges were performed at weekly intervals.
Flemming Madsen+3 more
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Bioorganic & Medicinal Chemistry Letters, 2019
Ginsenoside Compound K (CK) showed potent activity against IgE for the treatment of asthma. A series of CK analogues were then synthesized by straightforward procedures. The in vivo anti-IgE activity evaluations using the OVA-induced asthmatic mouse model revealed preliminary SARs of the CK analogues, which showed that the sugar type, modifications on ...
Sumei Ren+4 more
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Ginsenoside Compound K (CK) showed potent activity against IgE for the treatment of asthma. A series of CK analogues were then synthesized by straightforward procedures. The in vivo anti-IgE activity evaluations using the OVA-induced asthmatic mouse model revealed preliminary SARs of the CK analogues, which showed that the sugar type, modifications on ...
Sumei Ren+4 more
openaire +2 more sources
[Report on experiences with a new anti-asthmatic agent].
Ellen S. Koster
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[Letter: Phenacetin-containing anti-asthmatic agents].
K P Bopp
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Bioorganic & Medicinal Chemistry, 2006
The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route.
Lawson, E C+10 more
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The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route.
Lawson, E C+10 more
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Yoshiyuki Yamada, Hirokazu Arakawa
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Double-blind evaluation of an anti-asthmatic agent.
D L, Unger, L, Unger, D E, Temple
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[Progress of therapeutic agents for asthma--1) Progress of anti-asthmatic agents].
H, Kawamura, H, Nagano
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Medical Hypotheses, 2016
Asthma is a multi-factorial and complicated lung disorder of the immune system which has expanded to a wider ambit unveiling its etiology to be omnipresent at both ends of the spectrum involving basic pharmacology and in-depth immunology. As asthma occurs through triggered activation of various immune cells due to different stimuli, it poses a great ...
Kalidhindi Rama Satyanarayana Raju+8 more
openaire +3 more sources
Asthma is a multi-factorial and complicated lung disorder of the immune system which has expanded to a wider ambit unveiling its etiology to be omnipresent at both ends of the spectrum involving basic pharmacology and in-depth immunology. As asthma occurs through triggered activation of various immune cells due to different stimuli, it poses a great ...
Kalidhindi Rama Satyanarayana Raju+8 more
openaire +3 more sources