Results 81 to 90 of about 59,985 (224)
United European Gastroenterology Journal, EarlyView.ABSTRACT Background and aims Probe‐based confocal endomicroscopy (pCLE) allows real‐time microscopic visualization of the intestinal mucosa surface layers. Despite remission achieved through anti‐tumor necrosis factor or vedolizumab therapy, anomalies in the intestinal epithelial barrier are observed in inflammatory bowel disease (IBD) patients.
Thanh‐Hien Trieu +5 more
wiley +1 more source
The Journal of Dermatology, EarlyView.Abstract Guselkumab is a monoclonal antibody that binds to the p19 subunit of interleukin‐23 and inhibits its downstream signaling. The safety profile of guselkumab and its superior efficacy over placebo and adalimumab for the treatment of patients with moderate‐to‐severe psoriasis were reported in phase 3 studies conducted within and outside Japan. To
Yayoi Tada +6 more
wiley +1 more source
The Journal of Dermatology, EarlyView.ABSTRACT Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease worldwide. In the difficult‐to‐treat BP or if standard therapies are contraindicated, the use of biologics may be also considered although there is no strong evidence supporting their use.
Gianluca Avallone +50 more
wiley +1 more source
An Efficient Synthesis of the Anti-asthmatic Agent T-440: A Selective N-Alkylation of 2-Pyridone.
, 2000 M. Sugahara +5 more
openalex +2 more sources
Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications
Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022 Abstract Nutraceuticals have emerged as potential compounds to attenuate the COVID‐19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access.
Keshav Raj Paudel +19 more
wiley +1 more source
Aging Cell, EarlyView.During spread of Streptococcus pneumoniae from the lung to the bloodstream, the pneumococcal pore‐forming toxin pneumolysin (PLY) disrupts apical junction complexes (AJCs) and triggers the transmigration of polymorphonuclear leukocytes (PMNs), which secrete tissue‐destructive neutrophil elastase.
Shuying Xu +4 more
wiley +1 more source
SYNTHESIS OF SOME NOVEL 1,3,6-TRISUBSTITUTED-1HTHIAZOLO[3,2-f]PURINE-2,4-DIONES AND XANTHINE SCHIFF BASES AS POTENIAL ANTI-ASTHMATIC AND ANTIINFLAMMATORY AGENTS [PDF]
, 2015 Alaa M. Hayallah +2 more
openalex +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source