Results 251 to 260 of about 639,638 (307)

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Green mycosynthesis of a CuO/ZnO heterojunction nanocomposite using Aspergillus terreus and its antibacterial and anti-virulence activity against multidrug-resistant Escherichia coli. [PDF]

Sci Rep
Obaid AN, Abdelghany TM, Soliman AM, Mahmoud NN, Mekky AE.   +4 more
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Characterization of Endolysin LysG77YL from <i>Bacillus licheniformis</i>-Infecting Bacteriophage G77YL and Application as an Antimicrobial Agent. [PDF]

J Microbiol Biotechnol
Park N, Cho Y, Kang Y, Kong M.
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Effect of <i>Euphorbia neriifolia</i> L. leaf juice on the growth of <i>Pseudomonas aeruginosa</i> from otitis externa: an <i>in vitro</i> study. [PDF]

Front Pharmacol
Zahara D, Ichwan M, Simanjuntak Y.
europepmc   +1 more source

Bacteriophages as Antibacterial Agents Against Bovine Pathobionts Associated with Foodborne Human Morbidity. [PDF]

Viruses
Garvey M.
europepmc   +1 more source

Identification of the cannabinoid receptor 1 antagonist, ibipinabant, as a potent inhibitor of <i>Neisseria gonorrhoeae</i>. [PDF]

Antimicrob Agents Chemother
Dove AS, Abdelsattar AS, Abutaleb NS, Seleem MN.   +3 more
europepmc   +1 more source

Application and Potential of Local Drug Delivery Systems for Antibacterial Treatment of Periodontitis. [PDF]

Int J Mol Sci
Wang X, Wu F, Liu J, Hong X, Dong S.
europepmc   +1 more source

Polyphenolic compounds in <i>Glycyrrhiza</i> spp.: a potential weapon against multidrug-resistant pathogens. [PDF]

Front Pharmacol
Rafiq M, Xie Z, Hameed S, Xiao H, Luo Y, Chen K, Yang J, Hu L, Guo M, Cheng C.   +9 more
europepmc   +1 more source