Results 41 to 50 of about 1,350 (264)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Review of "Possessing Polynesians: The Science of Settler Colonial Whiteness in Hawai`i and Oceania" by Maile Arvin (Duke University Press)

Lateral, 2020
Arvin explains how dispossessing Polynesians was predicated on a logic of settler colonialism inflected by white supremacy. Casting Polynesians as white—specifically, as “almost white”—as opposed to distancing Polynesians from Caucasians, simultaneously ...
Christine Rosenfeld
doaj   +1 more source

From the Hood to the White House: The Cultural Imaginary of Presidential Blackness in Head of State

American Studies in Scandinavia, 2020
This article analyzes the film Head of State’s cultural imaginary of presidential blackness that signifies national progress while sublimating social conflict.
Atalie Gerhard
doaj   +1 more source

Combating Anti-Blackness in the AI Community

CoRR, 2020
In response to a national and international awakening on the issues of anti-Blackness and systemic discrimination, we have penned this piece to serve as a resource for allies in the AI community who are wondering how they can more effectively engage with dismantling racist systems.
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

To Blanch an Ethiop: Motifs of Blackness in The Tempest and Ben Jonson’s Masque of Blackness

Humanities
In the period between 2021 and 2022 immediately following the COVID-19 lockdowns, there were 37 professional or academic productions of The Tempest in the United States.
Christina Lynn Gutierrez-Dennehy
doaj   +1 more source

Review of "Skin Theory: Visual Culture and the Postwar Prison Laboratory" by Cristina Visperas (New York University Press)

Lateral, 2023
In "Skin Theory," Cristina Visperas identifies how the captive body in the postwar era is positioned as the ideal test subject. She does so through a thorough interrogation of Albert Kligman’s primarily dermatological human experiments at Holmesburg ...
Patrick Teed
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source