Results 131 to 140 of about 1,972,524 (235)
ENT1 inhibition links oligodendrocyte lipid metabolism to connectivity in tauopathy
Abstract INTRODUCTION Metabolic dysfunction, altered adenosine signaling, and white matter abnormalities are implicated in tauopathies, but their relationship to network disconnection remains unclear. Myelinating oligodendrocytes may represent a metabolically vulnerable hub linking these processes to circuit dysfunction.
Ching‐Pang Chang +7 more
wiley +1 more source
The objective of the present research was to evaluate the usefulness of anti-cyclic citrullinated peptide (anti-CCP) antibodies and the IgM rheumatoid factor (IgM RF) test for the differential diagnosis of leprosy with articular involvement and ...
S.L.E. Ribeiro +4 more
doaj
ABSTRACT Idiopathic multicentric Castleman disease can rarely present with systemic inflammation and erosive seronegative polyarthritis. Awareness of this association helps prevent misdiagnosis and ensures appropriate immunosuppressive management based on clinicopathological and immunohistochemical correlation.
Birahim Lo +9 more
wiley +1 more source
ABSTRACT Background Psoriatic arthritis (PsA) is a chronic inflammatory disease with complex pathophysiology. Despite advancements in biologic and targeted synthetic disease‐modifying antirheumatic drugs (b/tsDMARDs), treatment responses remain suboptimal for many patients.
Mengduan Pang +3 more
wiley +1 more source
In Contrast to Anti-CCP, MMP-Degraded and Citrullinated Vimentin (VICM) Is Both a Diagnostic and a Treatment Response Biomarker. [PDF]
Drobinski PJ +5 more
europepmc +1 more source
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang +10 more
wiley +1 more source
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid +4 more
wiley +1 more source
Effects of Human Leukocyte Antigen DRB1 Genetic Polymorphism on Anti-Cyclic Citrullinated Peptide (ANTI-CCP) and Rheumatoid Factor (RF) Expression in Rheumatoid Arthritis (RA) Patients. [PDF]
Chen YC +8 more
europepmc +1 more source
UBE2D4 Upregulation Promotes Cuproptosis Sensitivity in Colorectal Cancer
UBE2D4 is genetically upregulated in colorectal cancer and its expression status modulates copper‐induced cuproptosis sensitivity. Copper overload induces UBE2D4 and DLAT expression; UBE2D4 knockdown attenuates DLAT induction and rescues cell viability, suggesting UBE2D4 as a genetic determinant of cuproptosis sensitivity and a potential stratification
Biaoyu Wang +3 more
wiley +1 more source
HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status. [PDF]
Sharma S +6 more
europepmc +1 more source

