Results 41 to 50 of about 42,186 (261)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

ESSENCE AND COMPONENTS OF INNOVATION POTENTIAL IN THE SYSTEM OF CRISIS MANAGEMENT

Модернизация, инновация, развитие, 2015
The article specifies the concept and composition of innovation potential and off ers the structure of this economic category. The concept of the innovation potential of the company is considered.
N. G. Akulova, A. S. Urusov
doaj  

Оrganization of anti-crisis personnel management in agricultural enterprises

Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2017
The research deals with the basic principles of the use of anti-crisis personnel management in enterprises of agriculture. The paper theoretically proves the implementation efficiency of anti-crisis personnel management in enterprises of agriculture ...
Mylyar T.S. , Golovach K.S.
doaj   +1 more source

MARKETING SUPPORT FOR ANTI-CRISIS MANAGEMENT OF AN AGRICULTURAL ENTERPRISE

Economics & Education, 2023
The purpose of the article is to study the theoretical approaches of anti-crisis management, to generalise the causes of crisis phenomena of agricultural enterprises, to determine the main components of marketing support in the anti-crisis management ...
Mariia Bahorka, Liudmila Kvasova, Yuliia Yakubenko   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Conceptual model of the process of rehabilitating institutional anti-crisis management of enterprises

Russian Journal of Economics and Law, 2019
Objective: to develop the stages of rehabilitation anti-crisis management of an enterprise in order to improve the quality of anti-crisis management in general.Method: abstract-logical.Results: the need to study and implement crisis management is due to ...
E. A. Buranova
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

SOLVING PROBLEMS IN THE RUSSIAN IMPORT SUBSTITUTION CONDITIONS OF ECONOMIC SANCTIONS

Модернизация, инновация, развитие, 2015
The article analyzes some problems of the Russian economy, including the problem of import substitution, the possible directions of their solutions, the need to identify priorities and priority sectors in the fi rst place, do not compete on the ...
A. N. Rjahovskaja, D. I. Rjahovskij
doaj  

STRATEGIC ASPECTS OF ANTI-CRISIS MANAGEMENT OF ENTERPRISES DURING THE COVID-19 PANDEMIC

Вестник университета, 2020
The article considers the strategic aspects of anti-crisis management of enterprises during the crisis. The paper clarifies the concept of crisis management, analyses the stages of crisis management, and identifies possible threats that arise for ...
N. N. Trofimova
doaj   +1 more source