Results 91 to 100 of about 741 (163)

Multimodal Integration of Protein Interactomes With Genomic and Molecular Data Discovers Distinct Rheumatoid Arthritis Endotypes

Arthritis &Rheumatology, Volume 78, Issue 8, Page 1653-1665, August 2026.
Objective Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease characterized by clinical and molecular heterogeneity, notably in the presence of anti–cyclic citrullinated peptide (CCP) antibodies. Patients with CCP+ RA exhibit more severe disease progression and distinct treatment responses compared to patients with CCP− RA.
Javad Rahimikollu, Priyamvada Guha Roy, Akash Kishore, Danica Morgan Lee, Lauren A. Vanderlinden, Kiran Nazarali, Fan Zhang, Dana P. Ascherman, Daniella M. Schwartz, Larry Moreland, Jishnu Das   +10 more
wiley   +1 more source

The Dynamic Alliance of p53 and Metabolism in the Tumor Microenvironment Shapes Tumor Evolution

BioEssays, Volume 48, Issue 8, August 2026.
p53 is an adaptive processor positioned at the interface between metabolism and the tumor microenvironment. By integrating nutrient, mechanical, inflammatory, and redox cues while reciprocally remodeling metabolism, stromal and immune compartments, and cancer cell plasticity, WT and mutant p53 orchestrate cell competition, tumor evolution, metastasis ...
Sebastien M. Joruiz, Francesco Napoletano, Rebecca Bertolio, Giannino Del Sal   +3 more
wiley   +1 more source

Rituximab is more effective than second anti-TNF therapy in rheumatoid arthritis patients and previous TNFα blocker failure

Biologics: Targets & Therapy, 2012
Joern Kekow,1 Ulf Mueller-Ladner,2 Hendrik Schulze-Koops31Clinic of Rheumatology and Orthopedics, Otto-von-Guericke University of Magdeburg, Vogelsang-Gommern; 2Department of Rheumatology and Clinical Immunology, Kerckhoff Clinic, Bad Nauheim; 3Division ...
Kekow J, Mueller-Ladner U, Schulze-Koops H   +2 more
doaj  

Clinical and Radiological Features Suggestive of Mucopolysaccharidosis in Two Siblings From Sudan: A Case Series

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Mucopolysaccharidosis should be suspected in patients presenting with multisystem involvement, including coarse facial features, skeletal abnormalities, and progressive organ dysfunction, particularly in resource‐limited settings where delayed diagnosis is common.
Alaa Bella, Mumen Abdalazim Dafallah, Ashraf Yousif Fadlalla, Bothaina Faisal Elmardi, Yomna Mohialdin Alataya, Abdalla Abdelmahmoud Abdalla, Mohammed Almeldin Ahmed Ibrahim, Mawada Faisal Nugud, Salah Elamin Ahmed Babiker, Hiba faroug Al_amin, Safaa Ayoub Yousif Mohammed, Moawia Elbalal Mohammed   +11 more
wiley   +1 more source

Improvement of Fibromyalgia by Immunoglobulin/Histamine Complex Therapy for Chronic Urticaria and Allergic Rhinitis: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Fibromyalgia (FM) is a chronic pain syndrome characterized by widespread musculoskeletal pain, often accompanied by fatigue, sleep disturbance, and cognitive symptoms. Although several treatment options are available, no curative therapy has been established.
Hyuk Soon Kim, Yunyoung Nam, Jeong Eun Sohn, Geunwoong Noh   +3 more
wiley   +1 more source

Disseminated Chronic Tophaceous Gout With Multi‐Tissue Involvement

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Gout is a metabolic condition in which hyperuricaemia leads to deposition of monosodium urate (MSU) crystals in synovial and peri‐articular tissues. (1) Acutely, synovial deposition causes a painful inflammatory reaction. Over time, chronic hyperuricaemia can lead to deposition of uric acid crystals in alternate tissues, with granulomatous ...
Yee Leng Loh, Fiona Combe
wiley   +1 more source

Cardiac Tamponade Secondary to Lupus Pericarditis Initially Misdiagnosed as Rheumatoid Arthritis: A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Systemic lupus erythematosus (SLE) can closely mimic rheumatoid arthritis, leading to diagnostic delays. In patients with atypical inflammatory arthritis, early echocardiographic evaluation is vital to detect rare but life‐threatening complications like cardiac tamponade, ensuring prompt transition from RA‐directed therapy to life‐saving ...
Ayush Bakhrel, Diwakar Koirala, Sushma Jaishi, Bishesh Kattel, Prabin Raj Pandit, Pradip Katuwal   +5 more
wiley   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, Volume 78, Issue 8, Page 959-966, August 2026.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Thromboinflammatory biomarkers in obstetric pathophysiology: Predictive insights into placental insufficiency and feto‐maternal adverse outcomes

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Placental insufficiency is a thromboinflammatory disorder driven by angiogenic imbalance, complement activation, endothelial dysfunction and coagulation dysregulation, leading to microvascular thrombosis, impaired uteroplacental perfusion and adverse maternal and fetal outcomes, including pre‐eclampsia, fetal growth restriction and stillbirth. Abstract
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Sustained response to rituximab in an ANCA‐negative necrotizing vasculitis with initial detection of Corynebacterium kroppenstedtii

Clinical &Translational Immunology, Volume 15, Issue 8, 2026.
Abstract Objectives In this case, we present a patient with rapidly progressive unilateral destructive orbital and midface inflammation. Initial detection of Corynebacterium kroppenstedtii was followed by a consistent course of localised necrotizing small‐vessel vasculitis, which was responsive to B‐cell depletion. Methods A 79‐year‐old woman presented
Nadine Al‐Azem, Anna Knothe, Jan‐Dirk Raguse, Inga Nierkamp, Achim Georg Beule, Claudia Rudack, Friedericke Müller, Anne Kerlikowki, Eva Wardelmann, Hermann Pavenstädt, Martin A Kriegel, Rebecca Hasseli   +11 more
wiley   +1 more source