Results 21 to 30 of about 477 (161)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The prevalence of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis

Jornal de Pediatria, 2005
OBJECTIVES: To assess the presence of anti-cyclic citrullinated peptide antibodies in a cohort of patients with juvenile idiopathic arthritis. METHODS: Anti-cyclic citrullinated peptide antibodies was tested for with an enzyme linked immunoabsorbent assay (ELISA) in serum samples of patients from the Hospital de Clínicas de Porto Alegre, all less than ...
Sandra H, Machado, Carlos A, von Mühlen, João C T, Brenol, Letícia, Bisotto, Ricardo Machado, Xavier   +4 more
openaire   +3 more sources

Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production

Immunological Medicine, 2020
Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by examining the changes of disease activity of RA and anti-
Hisakata Yamada, Tomomi Tsuru, Takeshi Otsuka, Masayuki Maekawa, Hiroshi Harada, Takaaki Fukuda, Hiroshi Tsukamoto, Akira Maeyama, Shigeru Yoshizawa, Ken Wada, Yasuharu Nakashima, Eisuke Shono, Seiji Yoshizawa, Hiroshi Jojima, Masakazu Kondo   +14 more
doaj   +1 more source

Serum Autoantibody Biomarkers for Management of Rheumatoid Arthritis Disease

Biosensors, 2023
Rheumatoid arthritis (RA) is a systemic chronic autoimmune inflammatory disease that is characterized by the destruction of bone and production of autoantibodies such as rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPAs).
Esther Sánchez-Tirado, Lourdes Agüí, Marta Sánchez-Paniagua, Araceli González-Cortés, Beatriz López-Ruiz, Paloma Yáñez-Sedeño, José M. Pingarrón   +6 more
doaj   +1 more source

Diagnostic utility of Anti-cyclic Citrullinated Peptide Antibodies for Very Early Rheumatoid Arthritis [PDF]

National Journal of Laboratory Medicine, 2014
Background and Objectives: Rheumatoid arthritis (RA) is a systemic autoimmune disorder characterized by widespread joint inflammation with synovial hyperplasia. The most well known diagnostic marker is rheumatoid factor (RF).However; RF is not a good
Sucilathangam G, Anna T, Velvizhi G
doaj   +1 more source

Anti-cyclic citrullinated peptide antibodies in patients with primary Sjögren's syndrome [PDF]

Annals of the Rheumatic Diseases, 2005
Primary Sjogren’s syndrome (pSS) is an autoimmune late onset disease characterised mainly by sicca symptoms. Lymphocytic infiltrate of the minor salivary glands and the presence of autoantibodies are the hallmarks of disease.1 The spectrum of pSS extends from an organ-specific autoimmune disorder (autoimmune exocrinopathy) to a systemic process that ...
Tobón, G J, Correa, P A, Anaya, Juan-Manuel   +2 more
openaire   +3 more sources

The Diagnostic Utility of Anti-cyclic Citrullinated Peptide Antibodies, Matrix Metalloproteinase-3, Rheumatoid Factor, Erythrocyte Sedimentation Rate, and C-reactive Protein in Patients with Erosive and Non-erosive Rheumatoid Arthritis

Clinical and Developmental Immunology, 2005
Objective: To compare the diagnostic utility of laboratory variables, including matrix metalloproteinase-3 (MMP-3), anti-cyclic citrullinated peptide (CCP) antibodies, rheumatoid factor (RF), erythrocyte sedimentation rate (ESR),
O. Shovman, B. Gilburd, G. Zandman-Goddard, Y. Sherer, H. Orbach, R. Gerli, Y. Shoenfeld   +6 more
doaj   +1 more source

Anti-Cyclic Citrullinated Peptide Antibodies in Rheumatoid Arthritis and Behcet's Disease

The Tohoku Journal of Experimental Medicine, 2007
Rheumatoid arthritis (RA) is associated with progressive joint destruction and disability. Early diagnosis of RA is important, since early and aggressive treatments lead to a better outcome. Circulating autoantibodies are a serological hallmark of systemic rheumatic diseases.
Koca, Suleyman Serdar, Akbulut, Handan, Dag, Sait, Artas, Hakan, Isik, Ahmet   +4 more
openaire   +3 more sources

The diagnostic value of anti-cyclic citrullinated peptide antibodies, adenosine deaminase activity and other potential biomarkers for predicting and monitoring rheumatoid arthritis [PDF]

Journal of Medical Biochemistry, 2008
The aim of this study was to investigate the presence of anti-cyclic citrullinated peptide antibodies (anti- CCP2) in RA and non-RA patients and to evaluate the combination of these auto-antibodies with some other markers such as RF and CRP.
Mehanović-Nikolić Jasminka, Laloš-Miljuš Jasenka, Stajčić-Nalesnik Milada, Lakić Ljiljana, Bobić Željka, Bogdanić Jelena, Vajić Nataša   +6 more
doaj  

Diagnostic Utility of AxSYM Anti-Cyclic Citrullinated Peptide Antibody Assay

Annals of Laboratory Medicine, 2008
The presence of rheumatoid factor (RF) is one of the classification criteria of the American College of Rheumatology (ACR) for rheumatoid arthritis (RA), but it has a limitation of low specificity. We compared the diagnostic utility of anti-cyclic citrullinated peptide (CCP) antibodies analyzed by an automated immunoassay system with that measured by a
Kyung-Eun, Kim, Kyeong-Hee, Kim, Kwang-Sook, Woo, Jin-Yeong, Han, Jeong-Man, Kim, Sung Won, Lee, Won Tae, Chung   +6 more
openaire   +2 more sources