Results 21 to 30 of about 3,095,599 (228)

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Klareskog, Lars, Lars Klareskog, Rikard Holmdahl, Kallberg, H, Padyukov, L, Lars Alfredsson, Harald Burkhardt, Padyukov, Leonid, Olsson, Lina, Holmdahl, Rikard, Lina M Olsson, Burkhardt, H, Anna-Karin Lindqvist, Leonid Padyukov, Lindqvist, Anna-Karin,, Burkhardt, Harald, Klareskog, L, Lindqvist, Anna-Karin, Olsson, Lina M., Henrik Källberg, Olsson, Lina,, Källberg, Henrik, Alfredsson, Lars, Alfredsson, L, Lund University., Holmdahl, Rikard,   +25 more
core   +1 more source

Anti-cyclic citrullinated peptide antibodies and paraoxonase-1 polymorphism in rheumatoid arthritis. [PDF]

BMC Musculoskelet Disord, 2014
Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease, with a worldwide prevalence of 0.5% to 1%. Anti-cyclic citrullinated peptide antibody (anti-CCP-2 Ab) is a marker of choice for diagnosing early and late RA. Anti-oxidant enzymes activity decreases in RA patients.
El-Banna H, Jiman-Fatani A.
europepmc   +4 more sources

Anti-Cyclic Citrullinated Peptide Frequency in Patients with Chronic Hepatitis C Virus Infection and Effect of Presence of Systemic Disease

Eurasian Journal of Medicine, 2019
Objective: Patients with chronic hepatitis C virus (HCV) infection may show a variety of rheumatic symptoms and signs. Anti-cyclic citrullinated peptide (anti-CCP) is widely used as as a marker, particularly for rheumatoid arthritis (RA), and may be ...
Ayşe Albayrak, Hakan Dursun, Muhammed Hamidullah Uyanik, Serkan Cerrah   +3 more
doaj   +1 more source

Peculiarities of immunological manifestations in patients with rheumatoid arthritis in the presence of chronic infection with Helicobacter pylori variant encoding cytotoxin-associated gene A

Медицинская иммунология, 2023
The study aimed to evaluate the association between cyclic citrullinated peptide antibody seropositivity and chronic Helicobacter pylori (H. pylori) infection in patients with rheumatoid arthritis (RA).
A. V. Aleksandrov, L. N. Shilova, V. A. Aleksandrov, M. V. Levkina, O. V. Paramonova, N. V. Aleksandrova, I. A. Zborovskaya   +6 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Anti‐cyclic citrullinated peptide antibodies in type 1 autoimmune hepatitis [PDF]

Alimentary Pharmacology & Therapeutics, 2005
SummaryBackground : Besides the autoantibodies included in the diagnostic criteria of type 1 autoimmune hepatitis, many other autoantibodies have been described in this condition. Recently, antibodies against cyclic citrullinated peptide have been validated as specific diagnostic and prognostic markers of rheumatoid arthritis.Aim : To assess whether ...
M, Fusconi, A, Vannini, A C, Dall'Aglio, G, Pappas, F, Cassani, G, Ballardini, M, Frisoni, A, Grassi, F B, Bianchi, D, Zauli   +9 more
openaire   +2 more sources

Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor-positive polyarticular juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal, 2011
Background Several studies have noted the significance of measuring anti-cyclic citrullinated peptide (CCP) antibodies in juvenile idiopathic arthritis (JIA) as an important indicator for destructive disease, as is the case in rheumatoid arthritis (RA ...
Dehlendorf Amanda B, Chauhan Anil K, Reed Melinda R, Gilliam Brooke E, Moore Terry L   +4 more
doaj   +1 more source

Anti-cyclic citrullinated peptide antibody (ACPA) and Rheumatoid arthritis: Clinical relevance [PDF]

Journal of Clinical Orthopaedics and Trauma, 2022
Rheumatoid Arthritis (RA) is the most common auto-immune, chronic inflammatory joint disease. Predominantly a musculoskeletal condition with a wide spectrum of skeletal and extra-skeletal manifestations, RA has a significant footfall in orthopaedic clinical practice worldwide. RA is essentially a clinical diagnosis; however, laboratory and radiographic
Karthikeyan. P. Iyengar, Abhishek Vaish, Arvind Nune   +2 more
openaire   +2 more sources

The diagnostic and prognostic value of IgG and IgA anti-citrullinated protein antibodies in patients with early rheumatoid arthritis

Frontiers in Immunology, 2023
ObjectivesAnti-citrullinated peptide antibodies (ACPA) are specific markers for rheumatoid arthritis (RA) and typically measured by assays employing a cyclic citrullinated peptide (CCP) as antigen.
Daniela Sieghart, Christian Konrad, Sascha Swiniarski, Helmuth Haslacher, Daniel Aletaha, Günter Steiner, Günter Steiner   +6 more
doaj   +1 more source

Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production

Immunological Medicine, 2020
Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by examining the changes of disease activity of RA and anti-
Hisakata Yamada, Tomomi Tsuru, Takeshi Otsuka, Masayuki Maekawa, Hiroshi Harada, Takaaki Fukuda, Hiroshi Tsukamoto, Akira Maeyama, Shigeru Yoshizawa, Ken Wada, Yasuharu Nakashima, Eisuke Shono, Seiji Yoshizawa, Hiroshi Jojima, Masakazu Kondo   +14 more
doaj   +1 more source