Results 1 to 10 of about 212,488 (218)

Phytochemical Characterization and Evaluation of the Antioxidant and Anti-Enzymatic Activity of Five Common Spices: Focus on Their Essential Oils and Spent Material Extractives

Plants, 2021
The essential oil industry of aromatic herbs and spices is currently producing a significant amount of by-products, such as the spent plant materials remaining after steam or hydrodistillation, that are simply discarded.
Adriana Trifan, Gokhan Zengin, Mihai Brebu, Krystyna Skalicka-Woźniak, Simon Vlad Luca   +4 more
doaj   +3 more sources

Dual-mechanism anti-CD73 antibodies CR201 and CR202 targeting distinct domains for cancer immunotherapy [PDF]

Frontiers in Immunology
BackgroundCD73 is a key enzyme in the adenosine-mediated immunosuppressive pathway and represents an attractive target for cancer immunotherapy. Here, we aimed to develop novel anti-CD73 antibodies with dual mechanisms of action by simultaneously ...
Miao Zhang, Miao Zhang, Haibin Yuan, Xindi Pan, Xian Li, Zichen Wang, Shuping Zhang, Zhigang Gu, Biao Hu, Xuedong Qu, Qian Wang, Xiangguo Gu, Bo Wang, Yu Cao, Guilin Mu, Guangbo Kang, Ario de Marco, Xiangshan Zhou, He Huang   +18 more
doaj   +2 more sources

Polyphenols from Citrus Tacle^® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy

Molecules, 2021
Tacle® is a citrus fruit obtained from the crossbreeding of Clementine and Tarocco cultivars. This fruit retains a promising nutraceutical potential most likely due to a high content in polyphenols, among which the main constituents are the two ...
Fedora Grande, Maria Antonietta Occhiuzzi, Maria Rosaria Perri, Giuseppina Ioele, Bruno Rizzuti, Giancarlo Statti, Antonio Garofalo   +6 more
doaj   +1 more source

Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects

Molecules, 2021
The antitumor activity of certain anti-inflammatory drugs is often attributed to an indirect effect based on the inhibition of COX enzymes. In the case of anti-inflammatory prodrugs, this property could be attributed to the parent molecules with ...
Fedora Grande, Francesca Giordano, Maria Antonietta Occhiuzzi, Carmine Rocca, Giuseppina Ioele, Michele De Luca, Gaetano Ragno, Maria Luisa Panno, Bruno Rizzuti, Antonio Garofalo   +9 more
doaj   +1 more source

Pulicaria incisa (Lam.) DC. as a Potential Source of Antioxidant, Antibacterial, and Anti-Enzymatic Bioactive Molecules: Phytochemical Constituents, In Vitro and In Silico Pharmacological Analysis

Molecules, 2023
Plants with medicinal benefits are a crucial source of compounds for developing drugs. This study was designed to determine the chemical composition, antibacterial, antibiofilm, antioxidant, and anti-enzymatic activities of Pulicaria incisa (Lam.) DC. We
Mousa Alreshidi, Mohammad A. Abdulhakeem, Riadh Badraoui, Giuseppe Amato, Lucia Caputo, Laura De Martino, Filomena Nazzaro, Florinda Fratianni, Carmen Formisano, Vincenzo De Feo, Mejdi Snoussi   +10 more
doaj   +1 more source

Hibiscus sabdariffa L. and Its Bioactive Constituents Exhibit Antiviral Activity against HSV-2 and Anti-enzymatic Properties against Urease by an ESI-MS Based Assay [PDF]

Molecules, 2017
For decades, Hibiscus sabdariffa L. and its phytochemicals have been shown to possess a wide range of pharmacologic properties. In this study, aqueous extract of Hibiscus sabdariffa (AEHS) and its bioactive constituent protocatechuic acid (PCA), have been evaluated in vitro for their antiviral activity against HSV-2 clinical isolates and anti-enzymatic
Sherif T. S. Hassan, Emil Švajdlenka, Kateřina Berchová-Bímová   +2 more
openaire   +3 more sources

Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics

Toxins, 2023
Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Weiming Ouyang, Tao Xie, Hui Fang, David M. Frucht   +3 more
doaj   +1 more source

Insights into the Phytochemical and Multifunctional Biological Profile of Spices from the Genus Piper

Antioxidants, 2021
Piper spices represent an inexhaustible reservoir of bioactive compounds that may act as drug leads in natural product research. The aim of this study was to investigate a series of methanolic fruit extracts obtained from P.
Simon Vlad Luca, Katarzyna Gaweł-Bęben, Marcelina Strzępek-Gomółka, Karolina Czech, Adriana Trifan, Gokhan Zengin, Izabela Korona-Glowniak, Mirjana Minceva, Jürg Gertsch, Krystyna Skalicka-Woźniak   +9 more
doaj   +1 more source

Phytochemical profile, enzyme inhibition activity and molecular docking analysis of Feijoa sellowiana O. Berg

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Feijoa sellowiana leaves and fruits have been investigated as a source of diverse bioactive metabolites. Extract and eight metabolites isolated from F.
Fatema R. Saber, Rehab M. Ashour, Ali M. El-Halawany, Mohamad Fawzi Mahomoodally, Gunes Ak, Gokhan Zengin, Engy A. Mahrous   +6 more
doaj   +1 more source

Probes and techniques used in active and the hypoxia-based dormant state of an antitubercular drug screening assay

Medicine in Drug Discovery, 2022
Current antitubercular drug therapy requires more than six months and is unable to kill latent or dormant forms of tuberculosis. Thus, it is a need of new drug therapy to fight against dormant tuberculosis.
Amar Yeware, Shamim Akhtar, Dhiman Sarkar   +2 more
doaj   +1 more source