Results 151 to 160 of about 212,488 (218)

Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, EarlyView.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

The acetylation mechanism and engineering strategy of isocitrate lyase for optimizing biosynthesis in <i>Escherichia coli</i>. [PDF]

Synth Syst Biotechnol
Jia R, Wang J, Zhang Y, Xian M, Qi Q, Liu M, Zhao G.   +6 more
europepmc   +1 more source

POSS‐PEG‐NHS and GSH Cocrosslink DPAV to Prepare Anticalcification Bioprosthetic Scaffold With Enhanced Reendothelization, Anti‐inflammation, and Anti‐ROS

Advanced Healthcare Materials, EarlyView.
POSS‐PEG‐NHS and GSH cocrosslinked DPAV to prepare a multifunctional anticalcification valve substitute. This modification enhances mechanical properties, hemocompatibility, and re‐endothelialization while promoting anti‐inflammatory M2 macrophage infiltration and reducing calcification.
Yuqing Zhang, Chen Qian, Yingjie He, Jingli Ding, Binhao Zhang, Minghui Zou, Xing Chen, Jinping Zhao, Cuifen Lu, Jinping Liu, Jianliang Zhou   +10 more
wiley   +1 more source

The protein phosphatase OsPP1a dephosphorylates and stabilizes CatC to scavenge excess H₂O₂ and enhance salt tolerance in rice. [PDF]

Plant Commun
Wang Y, Yi Y, Xu Z, Tian Y, Mao D, Luo Z, Zhou Z, Hu SN, Tan Y, Zhao X, Yang L, Tang D, Yang Y, Tang W, Liu C, Liu X, Lin J.   +16 more
europepmc   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Selective bioactive effects of <i>Anisosciadium lanatum</i> Boiss. [Apiaceae] essential oil: GC-MS profiling coupled with <i>in Vitro</i> and <i>in silico</i> screening. [PDF]

Front Pharmacol
Besbes M, Jilani S, Hamdi A, Dbeibia A, Rich S, Horchani M, Al-Shammari WB, AlArdan D, Alshammari AA, Ghorbel M, Hadj Lajimi R, Ben Jannet H, Ben Selma W.   +12 more
europepmc   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

The inhibitors of 17β-HSD10: are they any good? [PDF]

RSC Chem Biol
Kwa E, Ogilvie CE, Kormos NC, Green AJE, Smith TK, Gunn-Moore FJ.   +5 more
europepmc   +1 more source

A Modular Liver–Microbial Microfluidic Platform to Evaluate Therapeutic and Adverse Effects of Microbial Metabolites

Advanced Healthcare Materials, EarlyView.
This study introduces a modular microfluidic platform that connects liver cells with live microbes to mimic key aspects of the gut–liver interaction in steatosis. Using this system, both microbial metabolites and live bacteria significantly reduced fat accumulation in liver cells, but live microbes triggered inflammation and broader metabolic changes ...
Hsih‐Yin Tan, In Young Hwang, Nanthini Jayabalan, Hui Ling Lee, Louis Jun Ye Ong, Chwee Teck Lim, Matthew Wook Chang, Yi‐Chin Toh   +7 more
wiley   +1 more source

Morin inhibits fructose bisphosphate aldolase activity and resists Cryptosporidium parvum infection. [PDF]

Int J Parasitol Drugs Drug Resist
Chen M, Kang H, Yu Y, Zhang X, Zhang X, Wang X, Liu Z, Zheng Y, Gong P, Zhang N, Li X, Li J.   +11 more
europepmc   +1 more source